Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB08898"
| Predicate | Value (sorted: none) |
|---|---|
| drugbank:interactsWith | |
| rdf:type | |
| drugbank:description |
"Glucarpidase is the recombinant form of the Pseudomonas sp. (strain RS-16) enzyme carboxypeptidase G2 that is produced in Escherichia coli. In patients, glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. Therefore since methotrexate is eliminated enzymatically and not by the kidneys, glucarpidase is indicated in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (>1 micromole per liter). Glucarpidase is marketed under the brand name Voraxaze®."
|
| rdfs:label |
"Glucarpidase"
|
| drugbank:drugCategory | |
| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource appears as object in 2 triples