Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB08515"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE"
|
| rdf:type | |
| drugbank:description |
"
experimental
This compound belongs to the furopyrroles. These are organic polycyclic compounds containing a furan ring fused to a pyrrole ring.
Furopyrroles
Organic Compounds
Heterocyclic Compounds
Furopyrroles
Beta-hydroxy Aldehydes
Pyrrolidones
Oxolanes
Tetrahydrofurans
Pyrroles
Furans
Lactams
Secondary Alcohols
Secondary Carboxylic Acid Amides
Polyamines
Enolates
Carboxylic Acids
Ethers
beta-hydroxy aldehyde
pyrrolidone
oxolane
pyrrole
furan
tetrahydrofuran
pyrrolidine
secondary alcohol
secondary carboxylic acid amide
carboxamide group
lactam
polyamine
carboxylic acid derivative
enolate
carboxylic acid
ether
alcohol
organonitrogen compound
aldehyde
logP
0.67
ALOGPS
logS
-2.1
ALOGPS
Water Solubility
2.09e+00 g/l
ALOGPS
logP
0.22
ChemAxon
IUPAC Name
(3aR,6R,6aS)-6-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-6a-methyl-4-oxo-hexahydro-2H-furo[2,3-c]pyrrole-6-carbaldehyde
ChemAxon
Traditional IUPAC Name
(3aR,6R,6aS)-6-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-6a-methyl-4-oxo-tetrahydrofuro[2,3-c]pyrrole-6-carbaldehyde
ChemAxon
Molecular Weight
279.3315
ChemAxon
Monoisotopic Weight
279.147058165
ChemAxon
SMILES
[H][C@](O)([C@@]1([H])CCCC=C1)[C@]1(NC(=O)[C@]2([H])CCO[C@]12C)C=O
ChemAxon
Molecular Formula
C15H21NO4
ChemAxon
InChI
InChI=1S/C15H21NO4/c1-14-11(7-8-20-14)13(19)16-15(14,9-17)12(18)10-5-3-2-4-6-10/h3,5,9-12,18H,2,4,6-8H2,1H3,(H,16,19)/t10-,11+,12+,14+,15-/m1/s1
ChemAxon
InChIKey
InChIKey=YVABESCRHMBHJD-FUQNVFFISA-N
ChemAxon
Polar Surface Area (PSA)
75.63
ChemAxon
Refractivity
73.39
ChemAxon
Polarizability
28.77
ChemAxon
Rotatable Bond Count
3
ChemAxon
H Bond Acceptor Count
4
ChemAxon
H Bond Donor Count
2
ChemAxon
pKa (strongest acidic)
10.76
ChemAxon
pKa (strongest basic)
-2.1
ChemAxon
Physiological Charge
0
ChemAxon
Number of Rings
3
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
Ghose Filter
true
ChemAxon
PubChem Compound
11840981
PubChem Substance
99444986
ChemSpider
10015482
PDB
SA1
BE0003910
Proteasome subunit alpha type-1
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit alpha type-1
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMA1
11p15.1
Cytoplasm. Nucleus
None
6.6
29555.3
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9530
GeneCards
PSMA1
GenBank Gene Database
D00759
GenBank Protein Database
220022
UniProtKB
P25786
UniProt Accession
PSA1_HUMAN
30 kDa prosomal protein
Macropain subunit C2
Multicatalytic endopeptidase complex subunit C2
PROS-30
Proteasome component C2
Proteasome nu chain
>Proteasome subunit alpha type-1
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
QRKAQPAQPADEPAEKADEPMEH
>792 bp
ATGTTTCGAAATCAGTATGACAATGATGTCACTGTTTGGAGCCCCCAGGGCAGGATTCAT
CAAATTGAATATGCAATGGAAGCTGTTAAACAAGGTTCAGCCACAGTTGGTCTGAAATCA
AAAACTCATGCAGTTTTGGTTGCATTGAAAAGGGCGCAATCAGAGCTTGCAGCTCATCAG
AAAAAAATTCTCCATGTTGACAACCATATTGGTATCTCAATTGCGGGGCTTACTGCTGAT
GCTAGACTGTTATGTAATTTTATGCGTCAGGAGTGTTTGGATTCCAGATTTGTATTCGAT
AGACCACTGCCTGTGTCTCGTCTTGTATCTCTAATTGGAAGCAAGACCCAGATACCAACA
CAACGATATGGCCGGAGACCATATGGTGTTGGTCTCCTTATTGCTGGTTATGATGATATG
GGCCCTCACATTTTCCAAACCTGTCCATCTGCTAACTATTTTGACTGCAGAGCCATGTCC
ATTGGAGCCCGTTCCCAATCAGCTCGTACTTACTTGGAGAGACATATGTCTGAATTTATG
GAGTGTAATTTAAATGAACTAGTTAAACATGGTCTGCGTGCCTTAAGAGAGACGCTTCCT
GCAGAACAGGACCTGACTACAAAGAATGTTTCCATTGGAATTGTTGGTAAAGACTTGGAG
TTTACAATCTATGATGATGATGATGTGTCTCCATTCCTGGAAGGTCTTGAAGAAAGACCA
CAGAGAAAGGCACAGCCTGCTCAACCTGCTGATGAACCTGCAGAAAAGGCTGATGAACCA
ATGGAACATTAA
PF00227
Proteasome
PF10584
Proteasome_A_N
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
BE0003911
Proteasome subunit alpha type-2
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit alpha type-2
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation
PSMA2
7p13
Cytoplasm. Nucleus
None
7.55
25898.4
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9531
GeneCards
PSMA2
GenBank Gene Database
D00760
GenBank Protein Database
220024
UniProtKB
P25787
UniProt Accession
PSA2_HUMAN
Macropain subunit C3
Multicatalytic endopeptidase complex subunit C3
Proteasome component C3
>Proteasome subunit alpha type-2
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
>705 bp
ATGGCGGAGCGCGGGTACAGCTTTTCGCTGACTACATTCAGCCCGTCTGGTAAACTTGTC
CAGATTGAATATGCTTTGGCTGCTGTAGCTGGAGGAGCCCCGTCCGTGGGAATTAAAGCT
GCAAATGGTGTGGTATTAGCAACTGAGAAAAAACAGAAATCCATTCTGTATGATGAGCGA
AGTGTACACAAAGTAGAACCAATTACCAAGCATATAGGTTTGGTGTACAGTGGCATGGGC
CCCGATTACAGAGTGCTTGTGCACAGAGCTCGAAAACTAGCTCAACAATACTATCTTGTG
TACCAAGAACCCATTCCTACAGCTCAGCTGGTACAGAGAGTAGCTTCTGTGATGCAAGAA
TATACTCAGTCAGGTGGTGTTCGTCCATTTGGAGTTTCTTTACTTATTTGTGGTTGGAAT
GAGGGACGACCATATTTATTTCAGTCAGATCCATCTGGAGCTTACTTTGCCTGGAAAGCT
ACAGCAATGGGAAAGAACTATGTGAATGGGAAGACTTTCCTTGAGAAAAGATATAATGAA
GATCTGGAACTTGAAGATGCCATTCATACAGCCATCTTAACCCTAAAGGAAAGCTTTGAA
GGGCAAATGACAGAGGATAACATAGAAGTTGGAATCTGCAATGAAGCTGGATTTAGGAGG
CTTACTCCAACTGAAGTTAAGGATTACTTGGCTGCCATAGCATAA
PF00227
Proteasome
PF10584
Proteasome_A_N
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
hydrolase activity
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
BE0003912
Proteasome subunit alpha type-3
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit alpha type-3
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMA3
14q23
Cytoplasm. Nucleus
None
4.97
28433.0
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9532
GeneCards
PSMA3
GenBank Gene Database
D00762
GenBank Protein Database
220028
UniProtKB
P25788
UniProt Accession
PSA3_HUMAN
Macropain subunit C8
Multicatalytic endopeptidase complex subunit C8
Proteasome component C8
>Proteasome subunit alpha type-3
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
KESLKEEDESDDDNM
>768 bp
ATGAGCTCAATCGGCACTGGGTATGACCTGTCAGCCTCTACATTCTCTCCTGACGGAAGA
GTTTTTCAAGTTGAATATGCTATGAAGGCTGTGGAAAATAGTAGTACAGCTATTGGAATC
AGATGCAAAGATGGTGTTGTCTTTGGGGTAGAAAAATTAGTCCTTTCTAAACTTTATGAA
GAAGGTTCCAACAAAAGACTTTTTAATGTTGATCGGCATGTTGGAATGGCAGTAGCAGGT
TTGTTGGCAGATGCTCGTTCTTTAGCAGACATAGCAAGAGAAGAAGCTTCCAACTTCAGA
TCTAACTTTGGCTACAACATTCCACTAAAACATCTTGCAGACAGAGTGGCCATGTATGTG
CATGCATATACACTCTACAGTGCTGTTAGACCTTTTGGCTGCAGTTTCATGTTAGGGTCT
TACAGTGTGAATGACGGTGCGCAACTCTACATGATTGACCCATCAGGTGTTTCATACGGT
TATTGGGGCTGTGCCATCGGCAAAGCCAGGCAAGCTGCAAAGACGGAAATAGAGAAGCTT
CAGATGAAAGAAATGACCTGCCGTGATATCGTTAAAGAAGTTGCAAAAATAATTTACATA
GTACATGACGAAGTTAAGGATAAAGCTTTTGAACTAGAACTCAGCTGGGTTGGTGAATTA
ACTAATGGAAGACATGAAATTGTTCCAAAAGATATAAGAGAAGAAGCAGAGAAATATGCT
AAGGAATCTCTGAAGGAAGAAGATGAATCAGATGATGATAATATGTAA
PF00227
Proteasome
PF10584
Proteasome_A_N
component
protein complex
component
proteasome core complex (sensu Eukaryota)
component
proteasome complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
BE0003913
Proteasome subunit alpha type-4
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit alpha type-4
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMA4
15q25.1
Cytoplasm. Nucleus
None
7.86
29483.6
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9533
GeneCards
PSMA4
GenBank Gene Database
D00763
GenBank Protein Database
220030
UniProtKB
P25789
UniProt Accession
PSA4_HUMAN
Macropain subunit C9
Multicatalytic endopeptidase complex subunit C9
Proteasome component C9
Proteasome subunit L
>Proteasome subunit alpha type-4
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF
FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA
YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK
EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH
EEEEAKAEREKKEKEQKEKDK
>786 bp
ATGTCTCGAAGATATGACTCCAGGACCACTATATTTTCTCCAGAAGGTCGCTTATACCAA
GTTGAATATGCCATGGAAGCTATTGGACATGCAGGCACCTGTTTGGGAATTTTAGCAAAT
GATGGTGTTTTGCTTGCAGCAGAGAGACGCAACATCCACAAGCTTCTTGATGAAGTCTTT
TTTTCTGAAAAAATTTATAAACTCAATGAGGACATGGCTTGCAGTGTGGCAGGCATAACT
TCTGATGCTAATGTTCTGACTAATGAACTAAGGCTCATTGCTCAAAGGTATTTATTACAG
TATCAGGAGCCAATACCTTGTGAGCAGTTGGTTACAGCACTGTGTGATATCAAACAAGCT
TATACACAATTTGGAGGAAAACGTCCCTTTGGTGTTTCATTGCTGTACATTGGCTGGGAT
AAGCACTATGGCTTTCAGCTCTATCAGAGTGACCCTAGTGGAAATTACGGGGGATGGAAG
GCCACATGCATTGGAAATAATAGCGCTGCAGCTGTGTCAATGTTGAAACAAGACTATAAA
GAAGGAGAAATGACCTTGAAGTCAGCACTTGCTTTAGCTATCAAAGTACTAAATAAGACC
ATGGATGTTAGTAAACTCTCTGCTGAAAAAGTGGAAATTGCAACACTAACAAGAGAGAAT
GGAAAGACAGTAATCAGAGTTCTCAAACAAAAAGAAGTGGAGCAGTTGATCAAAAAACAT
GAGGAAGAAGAAGCCAAAGCTGAGCGTGAGAAGAAAGAAAAAGAACAGAAAGAAAAGGAT
AAATAG
PF00227
Proteasome
PF10584
Proteasome_A_N
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
BE0003914
Proteasome subunit alpha type-5
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit alpha type-5
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMA5
1p13
Cytoplasm. Nucleus
None
4.45
26410.8
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9534
GeneCards
PSMA5
GenBank Gene Database
X61970
GenBank Protein Database
296740
UniProtKB
P28066
UniProt Accession
PSA5_HUMAN
Macropain zeta chain
Multicatalytic endopeptidase complex zeta chain
Proteasome zeta chain
>Proteasome subunit alpha type-5
MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME
PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA
LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS
LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD
I
>726 bp
ATGTTTCTTACCCGGTCTGAGTACGACAGGGGCGTGAATACTTTTTCTCCCGAAGGAAGA
TTATTTCAAGTGGAATATGACATTGAGGCTATCAAGCTTGGTTCTACAGCCATTGGGATC
CAGACATCAGAGGGTGTGTGCCTAGCTGTGGAGAAGAGAATTACTTCCCCACTGATGGAG
CCCAGCAGCATTGAGAAAATTGTAGAGATTGATGCTCACATAGGTTGTGCCATGAGTGGG
CTAATTGCTGATGCTAAGACTTTAATTGATAAAGCCAGAGTGGAGACACAGAACCACTGG
TTCACCTACAATGAGACAATGACAGTGGAGAGTGTGACCCAAGCTGTGTCCAATCTGGCT
TTGCAGTTTGGAGAAGAAGATGCAGATCCAGGTGCCATGTCTCGTCCCTTTGGAGTAGCA
TTATTATTTGGAGGAGTTGATGAGAAAGGACCCCAGCTGTTTCATATGGACCCATCTGGG
ACCTTTGTACAGTGTGATGCTCGAGCAATTGGCTCTGCTTCAGAGGGTGCCCAGAGCTCC
TTGCAAGAACTTTACCACAAGTCTATGACTTTGAAAGAAGCCATCAAGTCTTCACTCATC
ATCCTCAAACAAGTAATGGAGGAGAAGCTGAATGCAACAAACATTGAGCTAGCCACAGTG
CAGCCTGGCCAGAATTTCCACATGTTCACAAAGGAAGAACTTGAAGAGGTTATCAAGGAC
ATTTAA
PF00227
Proteasome
PF10584
Proteasome_A_N
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
hydrolase activity
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
BE0003915
Proteasome subunit alpha type-6
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit alpha type-6
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMA6
14q13
Cytoplasm. Nucleus
None
6.74
27399.2
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9535
GeneCards
PSMA6
GenBank Gene Database
X59417
GenBank Protein Database
35682
UniProtKB
P60900
UniProt Accession
PSA6_HUMAN
27 kDa prosomal protein
Macropain iota chain
Multicatalytic endopeptidase complex iota chain
p27K
PROS-27
Proteasome iota chain
>Proteasome subunit alpha type-6
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
>741 bp
ATGTCCCGTGGTTCCAGCGCCGGTTTTGACCGCCACATTACCATTTTTTCACCCGAGGGT
CGGCTCTACCAAGTAGAATATGCTTTTAAGGCTATTAACCAGGGTGGCCTTACATCAGTA
GCTGTCAGAGGGAAAGACTGTGCAGTAATTGTCACACAGAAGAAAGTACCTGACAAATTA
TTGGATTCCAGCACAGTGACTCACTTATTCAAGATAACTGAAAACATTGGTTGTGTGATG
ACCGGAATGACAGCTGACAGCAGATCCCAGGTACAGAGGGCACGCTATGAGGCAGCTAAC
TGGAAATACAAGTATGGCTATGAGATTCCTGTGGACATGCTGTGTAAAAGAATTGCCGAT
ATTTCTCAGGTCTACACACAGAATGCTGAAATGAGGCCTCTTGGTTGTTGTATGATTTTA
ATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTACTAC
TGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTTGAA
AAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATTACA
TGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTAGTG
ACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTT
GCTCTAGCAGAGAGAGACTAA
PF00227
Proteasome
PF10584
Proteasome_A_N
component
protein complex
component
proteasome core complex (sensu Eukaryota)
component
proteasome complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
BE0003916
Proteasome subunit alpha type-7
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit alpha type-7
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMA7
20q13.33
Cytoplasm. Nucleus
None
8.73
27886.6
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9536
GeneCards
PSMA7
GenBank Gene Database
AF022815
GenBank Protein Database
2555136
UniProtKB
O14818
UniProt Accession
PSA7_HUMAN
Proteasome subunit RC6-1
Proteasome subunit XAPC7
>Proteasome subunit alpha type-7
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR
KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ
SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA
IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE
KKKQKKAS
>747 bp
ATGAGCTACGACCGCGCCATCACCGTCTTCTCGCCCGACGGCCACCTCTTCCAAGTGGAG
TACGCGCAGGAGGCCGTCAAGAAGGGCTCGACCGCGGTTGGTGTTCGAGGAAGAGACATT
GTTGTTCTTGGTGTGGAGAAGAAGTCAGTGGCCAAACTGCAGGATGAAAGAACAGTGCGG
AAGATCTGTGCTTTGGATGACAACGTCTGCATGGCCTTTGCAGGCCTCACCGCCGATGCA
AGGATAGTCATCAACAGGGCCCGGGTGGAGTGCCAGAGCCACCGGCTGACTGTAGAGGAC
CCGGTCACTGTGGAGTACATCACCCGCTACATCGCCAGTCTGAAGCAGCGTTATACGCAG
AGCAATGGGCGCAGGCCGTTTGGCATCTCTGCCCTCATCGTGGGTTTCGACTTTGATGGC
ACTCCTAGGCTCTATCAGACTGACCCCTCGGGCACATACCATGCCTGGAAGGCCAATGCC
ATAGGCCGGGGTGCCAAGTCAGTGCGCGAGTTCCTGGAGAAGAACTATACTGACGAAGCC
ATTGAAACAGATGATCTGACCATTAAGCTGGTGATCAAGGCACTCCTGGAAGTGGTTCAG
TCAGGTGGCAAAAACATTGAACTTGCTGTCATGAGGCGAGATCAATCCCTCAAGATTTTA
AATCCTGAAGAAATTGAGAAGTATGTTGCTGAAATTGAAAAAGAAAAAGAAGAAAACGAA
AAGAAGAAACAAAAGAAAGCATCATGA
PF00227
Proteasome
PF10584
Proteasome_A_N
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
BE0002347
Proteasome subunit beta type-1
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit beta type-1
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMB1
6q27
Cytoplasm
None
8.29
26490.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9537
GenAtlas
PSMB1
GeneCards
PSMB1
GenBank Gene Database
D00761
GenBank Protein Database
220026
UniProtKB
P20618
UniProt Accession
PSB1_HUMAN
EC 3.4.25.1
Macropain subunit C5
Multicatalytic endopeptidase complex subunit C5
Proteasome component C5
Proteasome gamma chain
Proteasome subunit beta type 1 precursor
>Proteasome subunit beta type 1
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
D
>726 bp
ATGTTGTCCTCTACAGCCATGTATTCGGCTCCTGGCAGAGACTTGGGGATGGAACCGCAC
AGAGCCGCGGGCCCTTTGCAGCTGCGATTTTCGCCCTACGTTTTCAACGGAGGTACTATA
CTGGCAATTGCTGGAGAAGATTTTGCAATTGTTGCTTCTGATACTCGATTGAGTGAAGGG
TTTTCAATTCATACGCGGGATAGCCCCAAATGTTACAAATTAACAGACAAAACAGTCATT
GGATGCAGCGGTTTTCATGGAGACTGTCTTACGCTGACAAAGATTATTGAAGCAAGACTA
AAGATGTATAAGCATTCCAATAATAAGGCCATGACTACGGGGGCAATTGCTGCAATGCTG
TCTACAATCCTGTATTCAAGGCGCTTCTTTCCATACTATGTTTACAACATCATCGGTGGA
CTTGATGAAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTTACCAGAGA
GACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAG
GTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATG
CGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTGGGGACGCA
CTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAG
GACTGA
PF00227
Proteasome
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
hydrolase activity
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
BE0002349
Proteasome subunit beta type-2
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit beta type-2
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a chymotrypsin-like activity
PSMB2
1p34.2
Cytoplasm
None
7.04
22837.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9539
GenAtlas
PSMB2
GeneCards
PSMB2
GenBank Gene Database
D26599
GenBank Protein Database
565649
UniProtKB
P49721
UniProt Accession
PSB2_HUMAN
EC 3.4.25.1
Macropain subunit C7-I
Multicatalytic endopeptidase complex subunit C7-I
Proteasome component C7- I
>Proteasome subunit beta type 2
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
RIIDKNGIHDLDNISFPKQGS
>606 bp
ATGGAGTACCTCATCGGTATCCAAGGCCCCGACTATGTTCTTGTCGCCTCCGACCGGGTG
GCCGCCAGCAATATTGTCCAGATGAAGGACGATCATGACAAGATGTTTAAGATGAGTGAA
AAGATATTACTCCTGTGTGTTGGAGAGGCTGGAGACACTGTACAGTTTGCAGAATATATT
CAGAAAAACGTGCAACTTTATAAGATGCGAAATGGATATGAATTGTCTCCCACGGCAGCA
GCTAACTTCACACGCCGAAACCTGGCTGACTGTCTTCGGAGTCGGACCCCATATCATGTG
AACCTCCTCCTGGCTGGCTATGATGAGCATGAAGGGCCAGCGCTGTATTACATGGACTAC
CTGGCAGCCTTGGCCAAGGCCCCTTTTGCAGCCCACGGCTATGGTGCCTTCCTGACTCTC
AGTATCCTCGACCGATACTACACACCGACTATCTCACGTGAGAGGGCAGTGGAACTCCTT
AGGAAATGTCTGGAGGAGCTCCAGAAACGCTTCATCCTGAATCTGCCAACCTTCAGTGTT
CGAATCATTGACAAAAATGGCATCCATGACCTGGATAACATTTCCTTCCCCAAACAGGGC
TCCTAA
PF00227
Proteasome
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
BE0003917
Proteasome subunit beta type-3
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit beta type-3
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMB3
17q12
Cytoplasm. Nucleus
None
6.51
22948.7
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9540
GeneCards
PSMB3
GenBank Gene Database
D26598
GenBank Protein Database
565647
UniProtKB
P49720
UniProt Accession
PSB3_HUMAN
Proteasome chain 13
Proteasome component C10-II
Proteasome theta chain
>Proteasome subunit beta type-3
MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
SGMGVIVHIIEKDKITTRTLKARMD
>618 bp
ATGTCTATTATGTCCTATAACGGAGGGGCCGTCATGGCCATGAAGGGGAAGAACTGTGTG
GCCATCGCTGCAGACAGGCGCTTCGGGATCCAGGCCCAGTTGGTGACCACGGACTTCCAG
AAGATCTTTCCCATGGGTGACCGGCTGTACATCGGTCTGGCCGGGCTCGCCACTGACGTC
CAGACAGTTGCCCAGCGCCTCAAGTTCCGGCTGAACCTGTATGAGTTGAAGGAAGGTCGG
CAGATCAAACCTTATACCCTCATGAGCATGGTGGCCAACCTCTTGTATGAGAAACGGTTT
GGCCCTTACTACACTGAGCCAGTCATTGCCGGGTTGGACCCGAAGACCTTTAAGCCCTTC
ATTTGCTCTCTAGACCTCATCGGCTGCCCCATGGTGACTGATGACTTTGTGGTCAGTGGC
ACCTGCGCCGAACAAATGTACGGAATGTGTGAGTCCCTCTGGGAGCCCAACATGGATCCG
GATCACCTGTTTGAAACCATCTCCCAAGCCATGCTGAATGCTGTGGACCGGGATGCAGTG
TCAGGCATGGGAGTCATTGTCCACATCATCGAGAAGGACAAAATCACCACCAGGACACTG
AAGGCCCGAATGGACTAA
PF00227
Proteasome
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
BE0003918
Proteasome subunit beta type-4
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit beta type-4
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMB4
1q21
Cytoplasm (By similarity). Nucleus (By similarity)
None
5.77
29204.0
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9541
GeneCards
PSMB4
GenBank Gene Database
D26600
GenBank Protein Database
565651
UniProtKB
P28070
UniProt Accession
PSB4_HUMAN
HsBPROS26
HSN3
Macropain beta chain
Multicatalytic endopeptidase complex beta chain
Proteasome beta chain
Proteasome chain 3
>Proteasome subunit beta type-4
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVK
FEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEE
LLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAP
SLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEK
GVEIEGPLSTETNWDIAHMISGFE
>795 bp
ATGGAAGCGTTTTTGGGGTCGCGGTCCGGACTTTGGGCGGGGGGTCCGGCCCCAGGACAG
TTTTACCGCATTCCGTCCACTCCCGATTCCTTCATGGATCCGGCGTCTGCACTTTACAGA
GGTCCAATCACGCGGACCCAGAACCCCATGGTGACCGGGACCTCAGTCCTCGGCGTTAAG
TTCGAGGGCGGAGTGGTGATTGCCGCAGACATGCTGGGATCCTACGGCTCCTTGGCTCGT
TTCCGCAACATCTCTCGCATTATGCGAGTCAACAACAGTACCATGCTGGGTGCCTCTGGC
GACTACGCTGATTTCCAGTATTTGAAGCAAGTTCTCGGCCAGATGGTGATTGATGAGGAG
CTTCTGGGAGATGGACACAGCTATAGTCCTAGAGCTATTCATTCATGGCTGACCAGGGCC
ATGTACAGCCGGCGCTCGAAGATGAACCCTTTGTGGAACACCATGGTCATCGGAGGCTAT
GCTGATGGAGAGAGCTTCCTCGGTTATGTGGACATGCTTGGTGTAGCCTATGAAGCCCCT
TCGCTGGCCACTGGTTATGGTGCATACTTGGCTCAGCCTCTGCTGCGAGAAGTTCTGGAG
AAGCAGCCAGTGCTAAGCCAGACCGAGGCCCGCGACTTAGTAGAACGCTGCATGCGAGTG
CTGTACTACCGAGATGCCCGTTCTTACAACCGGTTTCAAACCGCCACTGTCACCGAAAAA
GGTGTTGAAATAGAGGGACCATTGTCTACAGAGACCAACTGGGATATTGCCCACATGATC
AGTGGCTTTGAATGA
PF00227
Proteasome
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
hydrolase activity
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
BE0002348
Proteasome subunit beta type-5
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit beta type-5
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
PSMB5
14q11.2
Cytoplasm
None
8.68
22897.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9542
GenAtlas
PSMB5
GeneCards
PSMB5
GenBank Gene Database
D29011
GenBank Protein Database
558526
UniProtKB
P28074
UniProt Accession
PSB5_HUMAN
EC 3.4.25.1
Macropain epsilon chain
Multicatalytic endopeptidase complex epsilon chain
Proteasome chain 6
Proteasome epsilon chain
Proteasome subunit beta type 5 precursor
Proteasome subunit MB1
Proteasome subunit X
>Proteasome subunit beta type 5
MLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWE
RLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDS
EGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNL
YHVREDGWIRVSSDNVADLHEKYSGSTP
>627 bp
ATGCTTCATGGAACAACCACCCTGGCCTTCAAGTTCCGCCATGGAGTCATAGTTGCAGCT
GACTCCAGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGATAGAG
ATCAACCCATACCTGCTAGGCACCATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAA
CGGCTGTTGGCTCGGCAATGTCGAATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTA
GCAGCTGCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCTGTCC
ATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGT
GAAGGGAACCGGATTTCAGGGGCCACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATAT
GGGGTCATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCC
CGTCGAGCCATCTACCAAGCCACCTACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTC
TACCACGTGCGGGAGGATGGCTGGATCCGAGTCTCCAGTGACAATGTGGCTGATCTACAT
GAGAAGTATAGTGGCTCTACCCCCTGA
PF00227
Proteasome
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
BE0003919
Proteasome subunit beta type-6
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit beta type-6
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May catalyze basal processing of intracellular antigens
PSMB6
17p13
Cytoplasm. Nucleus
None
4.54
25357.5
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9543
GeneCards
PSMB6
GenBank Gene Database
D29012
GenBank Protein Database
558528
UniProtKB
P28072
UniProt Accession
PSB6_HUMAN
Macropain delta chain
Multicatalytic endopeptidase complex delta chain
Proteasome delta chain
Proteasome subunit Y
>Proteasome subunit beta type-6
MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
>720 bp
ATGGCGGCTACCTTACTAGCTGCTCGGGGAGCCGGGCCAGCACCGGCTTGGGGGCCGGAG
GCATTCACTCCAGACTGGGAAAGCCGAGAAGTTTCCACTGGGACCACTATCATGGCCGTG
CAGTTTGACGGGGGCGTGGTTCTGGGGGCGGACTCCAGAACAACCACTGGGTCCTACATC
GCCAATCGAGTGACTGACAAGCTGACACCTATTCACGACCGCATTTTCTGCTGTCGCTCA
GGCTCAGCTGCTGATACCCAGGCAGTAGCTGATGCTGTCACCTACCAGCTCGGTTTCCAC
AGCATTGAACTGAATGAGCCTCCACTGGTCCACACAGCAGCCAGCCTCTTTAAGGAGATG
TGTTACCGATACCGGGAAGACCTGATGGCGGGAATCATCATCGCAGGCTGGGACCCTCAA
GAAGGAGGGCAGGGGTACTCAGTGCCTATGGGGGGTATGATGGTAAGGCAGTCCTTTGCC
ATTGGAGGCTCCGGGAGCTCCTACATCTATGGCTATGTTGATGCTACCTACCGGGAAGGC
ATGACCAAGGAAGAGTGTCTGCAATTCACTGCCAATGCTCTCGCTTTGGCCATGGAGCGG
GATGGCTCCAGTGGAGGAGTGATCCGCCTGGCAGCCATTGCAGAGTCAGGGGTAGAGCGG
CAAGTACTTTTGGGAGACCAGATACCCAAATTCGCCGTTGCCACTTTACCACCCGCCTGA
PF00227
Proteasome
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
function
hydrolase activity
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
BE0003920
Proteasome subunit beta type-7
Human
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Proteasome subunit beta type-7
Posttranslational modification, protein turnover, chaperones
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity
PSMB7
9q34.11-q34.12
Cytoplasm. Nucleus
None
7.79
29965.2
Human
HUGO Gene Nomenclature Committee (HGNC)
GNC:9544
GeneCards
PSMB7
GenBank Gene Database
D38048
GenBank Protein Database
1531533
UniProtKB
Q99436
UniProt Accession
PSB7_HUMAN
Macropain chain Z
Multicatalytic endopeptidase complex chain Z
Proteasome subunit Z
>Proteasome subunit beta type-7
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGAD
TRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVV
TANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAV
FEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGT
RLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
>834 bp
ATGGCGGCTGTGTCGGTGTATGCTCCACCAGTTGGAGGCTTCTCTTTTGATAACTGCCGC
AGGAATGCCGTCTTGGAAGCCGATTTTGCAAAGAGGGGATACAAGCTTCCAAAGGTCCGG
AAAACTGGCACGACCATCGCTGGGGTGGTCTATAAGGATGGCATAGTTCTTGGAGCAGAT
ACAAGAGCAACTGAAGGGATGGTTGTTGCTGACAAGAACTGTTCAAAAATACACTTCATA
TCTCCTAATATTTATTGTTGTGGTGCTGGGACAGCTGCAGACACAGACATGACAACCCAG
CTCATTTCTTCCAACCTGGAGCTCCACTCCCTCTCCACTGGCCGTCTTCCCAGAGTTGTG
ACAGCCAATCGGATGCTGAAGCAGATGCTTTTCAGGTATCAAGGTTACATTGGTGCAGCC
CTAGTTTTAGGGGGAGTAGATGTTACTGGACCTCACCTCTACAGCATCTATCCTCATGGA
TCAACTGATAAGTTGCCTTATGTCACCATGGGTTCTGGCTCCTTGGCAGCAATGGCTGTA
TTTGAAGATAAGTTTAGGCCAGACATGGAGGAGGAGGAAGCCAAGAATCTGGTGAGCGAA
GCCATCGCAGCTGGCATCTTCAACGACCTGGGCTCCGGAAGCAACATTGACCTCTGCGTC
ATCAGCAAGAACAAGCTGGATTTTCTCCGCCCATACACAGTGCCCAACAAGAAGGGGACC
AGGCTTGGCCGGTACAGGTGTGAGAAAGGGACTACTGCAGTCCTCACTGAGAAAATCACT
CCTCTGGAGATTGAGGTGCTGGAAGAAACAGTCCAAACAATGGACACTTCCTGA
PF00227
Proteasome
component
proteasome complex (sensu Eukaryota)
component
protein complex
component
proteasome core complex (sensu Eukaryota)
function
hydrolase activity
function
peptidase activity
function
endopeptidase activity
function
threonine endopeptidase activity
function
catalytic activity
process
metabolism
process
modification-dependent protein catabolism
process
ubiquitin-dependent protein catabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
process
proteolysis during cellular protein catabolism
"
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All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object