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Predicate	Value (sorted: default)
rdfs:label	"methyl [(1E,5R)-5-{(3S)-3-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate"
rdf:type	drugbank:drugs
drugbank:description	" experimental This compound belongs to the dihydropyranones. These are compounds containing an hydrogenated pyran ring which bears a ketone, and contains one double bond. Dihydropyranones Organic Compounds Heterocyclic Compounds Pyrans Pyranones and Derivatives Dicarboxylic Acids and Derivatives Acryloyl Compounds Enones Shiff Bases Carboxylic Acid Esters Polyamines Enolates Ethers Enols dicarboxylic acid derivative acryloyl-group enone carboxylic acid ester aldimine ketone shiff base ether enolate enol polyamine carboxylic acid derivative amine carbonyl group imine organonitrogen compound logP 4.39 ALOGPS logS -5.4 ALOGPS Water Solubility 1.73e-03 g/l ALOGPS logP 4.54 ChemAxon IUPAC Name methyl N-[(1E,5R)-5-[(3S)-3-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl]hexylidene]carbamate ChemAxon Traditional IUPAC Name methyl N-[(1E,5R)-5-[(5S)-5-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-4,6-dioxo-5H-pyran-2-yl]hexylidene]carbamate ChemAxon Molecular Weight 417.4953 ChemAxon Monoisotopic Weight 417.215137729 ChemAxon SMILES [H][C@@](C)(CCC\C=N\C(=O)OC)C1=CC(=O)[C@@]([H])(C(=O)C(\C)=C\C=C(/C)CCC)C(=O)O1 ChemAxon Molecular Formula C23H31NO6 ChemAxon InChI InChI=1S/C23H31NO6/c1-6-9-15(2)11-12-17(4)21(26)20-18(25)14-19(30-22(20)27)16(3)10-7-8-13-24-23(28)29-5/h11-14,16,20H,6-10H2,1-5H3/b15-11+,17-12+,24-13+/t16-,20+/m1/s1 ChemAxon InChIKey InChIKey=LTDLIPXLSBMTFP-HQCMHGIWSA-N ChemAxon Polar Surface Area (PSA) 99.1 ChemAxon Refractivity 116.4 ChemAxon Polarizability 45.49 ChemAxon Rotatable Bond Count 11 ChemAxon H Bond Acceptor Count 5 ChemAxon H Bond Donor Count 0 ChemAxon pKa (strongest acidic) 0.98 ChemAxon pKa (strongest basic) -2.5 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon PubChem Compound 46937136 PubChem Substance 99444737 PDB NE6 BE0004261 DNA-directed RNA polymerase subunit alpha Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown DNA-directed RNA polymerase subunit alpha Transcription DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA Cytoplasmic None 4.64 35012.9 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) GeneCards rpoA GenBank Gene Database AB024328 GenBank Protein Database 4519419 UniProtKB Q5SHR6 UniProt Accession RPOA_THET8 RNA polymerase subunit alpha RNAP subunit alpha Transcriptase subunit alpha >DNA-directed RNA polymerase subunit alpha MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPGTAVTSVYIED VLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADV EIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKDRINAIPVDAVFSPVRRVAFQ VEDTRLGQRTDLDKLTLRIWTDGSVTPLEALNQAVEILREHLTYFSNPQAAAVAAPEEAK EPEAPPEQEEELDLPLEELGLSTRVLHSLKEEGIESVRALLALNLKDLKNIPGIGERSLE EIKEALEKKGFTLKE >114 bp ATGAAGGTGCGCGCGTCGGTCAAGAGGATCTGCGACAAGTGCAAGGTGATCCGCCGGCAC GGGCGGGTCTACGTCATCTGCGAGAACCCCAAGCATAAGCAGCGGCAGGGTTAG PF01000 RNA_pol_A_bac PF03118 RNA_pol_A_CTD PF01193 RNA_pol_L component cell component intracellular function protein binding function protein dimerization activity function transferase activity function transferase activity, transferring phosphorus-containing groups function nucleic acid binding function binding function DNA binding function catalytic activity function nucleotidyltransferase activity function DNA-directed RNA polymerase activity process transcription, DNA-dependent process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process metabolism process cellular metabolism process transcription BE0003367 DNA-directed RNA polymerase subunit beta Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown DNA-directed RNA polymerase subunit beta Involved in DNA binding DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB Cytoplasmic None 5.73 125266.0 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) GenBank Gene Database AB083789 UniProtKB Q8RQE9 UniProt Accession RPOB_THET8 EC 2.7.7.6 RNA polymerase subunit beta RNAP beta subunit Transcriptase beta chain >DNA-directed RNA polymerase beta chain MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRENVGIQAAFRETFPIEEEDKG KGGLVLDFLEYRLGEPPFPQDECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLPKRGPWIDLEVEPNG VVSMKVNKRKFPLVLLLRVLGYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEKLGIRLSGRTLARFEDGEFKD EVFLPTLRYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRHKRRISALGPGGLTR ERAGFDVRDVHRTHYGRICPVETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGEPVIVSPEEVEFMDVSPKQVF SVNTNLIPFLEHDDANRALMGSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVGQRVRKGDLLADGPA SENGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTSFKGESEPTPEERLLRSIFGE KARDVKDTSLRVPPGEGGIVVRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQR YISPIFDGAKEPEIKELLAQAFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMHARSTGPYSLITQQP LGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR >3360 bp ATGGAGATCAAGCGGTTCGGTCGCATCCGAGAGGTTATCCCCCTTCCACCCCTCACCGAG ATCCAGGTGGAGTCCTACCGCAGGGCCCTGCAGGCCGACGTCCCCCCGGAGAAGCGGGAG AACGTCGGCATCCAGGCGGCCTTCCGGGAGACCTTCCCCATTGAGGAGGAGGACAAGGGC AAGGGCGGTTTGGTGCTGGACTTCCTGGAGTACCGCCTGGGCGAGCCCCCCTTCCCCCAG GACGAGTGCCGGGAGAAGGACCTCACCTACCAGGCCCCCCTCTACGCCCGGCTCCAGCTC ATCCACAAGGACACGGGCCTCATCAAGGAGGACGAGGTCTTCCTGGGGCACATCCCCCTG ATGACCGAGGACGGCTCCTTCATCATCAACGGGGCCGACCGGGTCATCGTCTCCCAGATC CACCGCTCCCCCGGGGTCTACTTCACCCCCGACCCCGCCCGGCCCGGGCGCTACATCGCC AGCATCATCCCCCTGCCCAAGCGGGGCCCCTGGATTGACCTGGAGGTGGAGCCGAACGGC GTCGTCTCCATGAAGGTCAACAAGCGGAAGTTCCCCCTGGTCCTCCTCCTTCGGGTCCTG GGGTACGACCAGGAGACCCTGGCCCGGGAGCTTGGGGCCTACGGGGAGCTGGTCCAGGGC CTCATGGACGAGAGCGTCTTCGCCATGCGCCCCGAGGAGGCTCTGATCCGCCTCTTCACC CTCCTCCGCCCCGGGGACCCGCCCAAGCGGGACAAGGCCGTGGCCTACGTCTACGGCCTC ATCGCCGACCCCAGGCGGTACGACCTGGGCGAGGCCGGGCGGTACAAGGCGGAGGAGAAG CTGGGGATCCGCCTCTCGGGCCGCACCCTGGCCCGCTTTGAGGACGGGGAGTTCAAGGAC GAGGTCTTCCTCCCCACCCTCCGCTACCTCTTCGCCCTCACCGCCGGGGTCCCGGGCCAC GAGGTGGACGACATTGACCACCTGGGCAACCGCCGCATCCGCACCGTGGGGGAGCTCATG ACCGACCAGTTCCGGGTGGGGCTCGCCCGCCTCGCCCGGGGGGTGCGGGAGCGGATGCTC ATGGGCTCGGAGGACAGCCTCACCCCGGCCAAGCTGGTGAACAGCCGCCCCTTGGAGGCC GCCATCCGGGAGTTCTTCAGCCGCAGCCAGCTTTCCCAGTTCAAGGACGAGACCAACCCC CTCTCCTCCCTGCGCCACAAGCGGCGGATCTCCGCCCTGGGCCCGGGCGGCCTCACCCGG GAGCGGGCGGGGTTTGACGTGCGCGACGTCCACCGCACCCACTACGGGCGCATCTGCCCC GTGGAGACCCCCGAGGGCGCCAACATCGGCCTCATCACCTCCTTGGCGGCCTACGCCCGG GTGGACGAGCTGGGCTTCATCCGCACCCCCTACCGCCGGGTGGTGGGCGGGGTGGTCACC GACGAGGTGGTCTACATGACGGCCACCGAGGAGGACCGCTACACCATCGCCCAGGCCAAC ACCCCCCTGGAGGGGAACCGGATCGCGGCCGAGCGGGTGGTGGCCCGGAGGAAGGGGGAG CCCGTGATCGTGAGCCCGGAAGAGGTGGAGTTCATGGACGTCTCCCCCAAGCAGGTCTTC TCCGTGAACACCAACCTCATTCCCTTCCTGGAGCACGACGACGCCAACCGGGCCCTCATG GGCTCCAACATGCAGACCCAGGCCGTGCCCCTCATCCGGGCCCAGGCCCCCGTGGTGATG ACGGGCCTCGAGGAGCGGGTGGTGCGGGACTCCCTGGCCGCCCTCTACGCCGAGGAGGAC GGGGAGGTGGCCAAGGTGGACGGCAACCGCATCGTCGTGCGCTACGAGGACGGCCGCCTG GTGGAGTACCCCTTGCGCCGCTTCTACCGCTCCAACCAGGGTACGGCCCTGGACCAGCGC CCCCGGGTGGTGGTGGGGCAGCGGGTGCGCAAAGGGGACCTCCTCGCCGACGGCCCCGCC TCCGAGAACGGCTTCCTGGCCCTGGGGCAGAACGTCCTCGTGGCCATCATGCCCTTTGAC GGGTACAACTTTGAGGACGCCATCGTCATCAGCGAGGAGCTCCTCAAGCGGGACTTCTAC ACCTCCATCCACATTGAGCGCTACGAGATTGAGGCCCGGGACACCAAGCTTGGCCCCGAG CGGATCACCCGGGACATCCCCCACCTCTCCGAGGCCGCCCTAAGGGACCTGGACGAGGAG GGCGTGGTGCGCATCGGCGCCGAGGTGAAGCCCGGGGACATCCTCGTGGGGCGGACCAGC TTCAAGGGCGAGTCCGAGCCCACCCCCGAGGAGAGGCTCCTCCGCTCCATCTTCGGCGAG AAGGCCCGGGACGTGAAGGACACCTCCCTCCGGGTGCCGCCCGGCGAAGGGGGGATCGTG GTCCGCACCGTCCGGCTGCGGCGGGGCGACCCCGGGGTGGAGCTCAAGCCCGGGGTGCGG GAGGTGGTCCGGGTCTACGTGGCCCAGAAGCGCAAGCTCCAGGTGGGGGACAAGCTCGCC AACCGCCACGGGAACAAGGGGGTGGTGGCCAAGATCCTCCCCGTGGAGGACATGCCCCAC CTGCCCGACGGCACCCCCGTGGACGTGATCCTGAACCCCCTGGGCGTCCCCAGCCGGATG AACCTGGGGCAGATCCTGGAGACCCACCTGGGCCTCGCCGGGTACTTCCTGGGCCAGCGC TACATCTCCCCCATCTTTGACGGGGCCAAGGAGCCCGAGATCAAGGAGCTCCTCGCCCAG GCCTTTGAGGTCTACTTCGGCAAGCGCAAGGGCGAGGGCTTCGGCGTGGACAAGCGGGAG GTGGAGGTCCTCCGCCGGGCGGAGAAGCTCGGCCTCGTCACCCCGGGCAAGACCCCGGAG GAGCAGCTTAAGGAGCTCTTCCTCCAGGGCAAGGTGGTCCTCTACGACGGCCGCACGGGC GAGCCCATTGAGGGCCCCATCGTGGTGGGACAGATGTTCATCATGAAGCTCTACCACATG GTGGAGGACAAGATGCACGCCCGCTCCACGGGGCCCTACTCCCTCATCACCCAGCAGCCC CTGGGCGGGAAGGCCCAGTTCGGCGGCCAGCGCTTCGGGGAGATGGAGGTCTGGGCCCTC GAGGCCTATGGGGCGGCCCACACCCTCCAGGAGATGCTCACCCTTAAGTCCGACGACATT GAGGGCAGGAACGCCGCCTACGAGGCCATCATCAAGGGGGAGGACGTTCCCGAGCCCAGC GTCCCCGAGTCCTTCCGCGTGCTGGTGAAGGAGCTCCAGGCCTTGGCCTTGGACGTGCAG ACCCTGGACGAGAAGGACAACCCCGTGGACATCTTTGAGGGGTTGGCCTCCAAGCGGTGA PF04563 RNA_pol_Rpb2_1 PF04561 RNA_pol_Rpb2_2 PF04565 RNA_pol_Rpb2_3 PF00562 RNA_pol_Rpb2_6 PF04560 RNA_pol_Rpb2_7 function catalytic activity function transferase activity function transferase activity, transferring phosphorus-containing groups function nucleic acid binding function DNA binding function nucleotidyltransferase activity function binding function DNA-directed RNA polymerase activity process metabolism process cellular metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process transcription BE0003368 DNA-directed RNA polymerase subunit beta' Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown DNA-directed RNA polymerase subunit beta' Involved in DNA binding DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC Cytoplasmic None 6.32 170759.0 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) GenBank Gene Database AB083790 UniProtKB Q8RQE8 UniProt Accession RPOC_THET8 EC 2.7.7.6 RNA polymerase beta' subunit RNAP beta' subunit Transcriptase beta' chain >DNA-directed RNA polymerase beta' chain MKKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGPIKDYECAC GKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSA TELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELRYGKQETYPLPPGVDALVK DGEEVVKGQELAPGVVSRLDGVALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGE ILAELPEPYLFRAEEEGVVELKELEEGAFLVLRREDEPVATYFLPVGMTPLVVHGEIVEK GQPLAEAKGLLRMPRQVRAAQVEAEEEGETVYLTLFLEWTEPKDYRVQPHMNVVVPEGAR VEAGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPFEDDVEVSTGDRVAPGDV LADGGKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEE MKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDL NDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPL RSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKK MEEKGIAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVL VEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAK PSRDIILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLK YVFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFARIVAEAVEDEKVAWELI QLDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEK KQYLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPL YVMAQSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKG GADTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADI EAGLYGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGV CQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRTFHTGGVAGAADITQGLPRVI ELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLVKDGDYVE AGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVE VTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASF QNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARK EAVEAKERPAARRGVKREQPGKQA >4575 bp ATGAAAAAAGAGGTTCGTAAGGTTCGCATCGCTTTGGCCTCCCCGGAGAAGATCCGCTCC TGGAGCTACGGGGAGGTGGAGAAGCCCGAGACCATCAACTACCGCACCCTCAAGCCCGAG CGGGACGGCCTCTTTGACGAGCGCATCTTCGGCCCCATCAAGGACTACGAGTGCGCCTGC GGCAAGTACAAGCGCCAGCGCTTTGAGGGCAAGGTGTGCGAGCGGTGTGGCGTGGAGGTG ACGAAGAGCATCGTCCGCCGCTACCGCATGGGGCACATTGAGCTCGCCACCCCCGCCGCC CACATCTGGTTCGTCAAGGACGTCCCCTCCAAGATCGGGACCCTCCTGGACCTTTCCGCC ACCGAGCTGGAGCAGGTCCTCTACTTCAGCAAGTACATCGTCTTGGATCCCAAGGGGGCC ATCCTGAACGGGGTCCCGGTGGAGAAGCGCCAGCTCCTCACCGACGAGGAGTACCGGGAG CTCCGCTACGGCAAGCAGGAGACCTACCCCCTGCCCCCCGGGGTGGACGCGCTGGTGAAG GACGGGGAGGAGGTGGTAAAGGGCCAGGAGCTTGCCCCCGGGGTGGTGAGCCGCCTGGAC GGCGTGGCCCTCTACCGCTTCCCCCGCCGCGTCCGGGTGGAGTACGTGAAGAAGGAGCGG GCCGGGCTCAGGCTTCCCCTCGCCGCCTGGGTGGAGAAGGAGGCCTACAAGCCCGGCGAA ATCCTCGCCGAGCTCCCCGAGCCCTACCTCTTCCGGGCCGAGGAGGAGGGCGTGGTGGAG CTTAAGGAGCTGGAGGAAGGGGCTTTCCTCGTCCTCCGCCGGGAGGACGAGCCGGTGGCC ACCTACTTCCTCCCCGTGGGCATGACGCCCCTCGTGGTCCACGGGGAGATCGTGGAGAAG GGCCAGCCCCTGGCCGAGGCCAAGGGCCTTCTCCGCATGCCCCGCCAGGTCCGGGCCGCC CAGGTGGAGGCGGAGGAGGAGGGGGAGACGGTCTACCTCACCCTCTTCCTGGAGTGGACG GAGCCCAAGGACTACCGCGTCCAGCCCCACATGAACGTGGTGGTCCCCGAGGGGGCCCGG GTGGAGGCGGGGGACAAGATCGTGGCCGCCATTGACCCCGAGGAGGAGGTCATCGCCGAG GCCGAGGGGGTGGTCCACCTCCACGAGCCCGCCAGCATCCTGGTGGTCAAGGCCCGGGTC TACCCCTTTGAGGACGACGTGGAGGTTTCCACCGGGGACCGGGTGGCCCCGGGGGACGTC CTCGCCGACGGGGGCAAGGTCAAAAGCGACGTCTACGGCCGGGTGGAGGTGGACCTGGTC CGCAACGTGGTCCGGGTGGTGGAGTCCTACGACATTGACGCCCGCATGGGGGCCGAGGCC ATCCAGCAGCTCCTCAAGGAGCTGGACCTCGAGGCCCTGGAGAAGGAGCTTCTGGAGGAG ATGAAGCACCCCTCCCGGGCCCGGCGGGCCAAGGCCAGGAAGCGCCTGGAGGTGGTGCGG GCCTTCCTGGACTCGGGGAACCGGCCCGAGTGGATGATCCTCGAGGCCGTCCCCGTCCTT CCCCCGGACCTCCGGCCCATGGTCCAGGTGGACGGCGGCCGCTTCGCCACGAGCGACCTC AACGACCTCTACCGCCGCCTCATCAACCGCAACAACCGGCTGAAGAAGCTCTTGGCCCAG GGGGCCCCCGAGATCATCATCCGCAACGAGAAGCGGATGCTCCAGGAGGCGGTGGACGCC CTCCTGGACAACGGCCGCCGCGGCGCTCCCGTGACCAACCCCGGCTCCGACCGGCCCCTC CGTAGCCTCACCGACATCCTCTCCGGCAAGCAGGGCCGCTTCCGCCAGAACCTCTTGGGC AAGCGGGTGGACTACTCGGGCCGGAGCGTGATCGTGGTGGGGCCCCAGCTCAAGCTCCAC CAGTGCGGCCTGCCCAAGCGGATGGCCCTGGAGCTCTTCAAGCCCTTCCTCCTCAAGAAG ATGGAGGAGAAGGGCATCGCCCCCAACGTCAAGGCGGCGCGGCGCATGCTGGAGCGCCAG CGGGACATCAAGGACGAGGTGTGGGACGCCTTGGAGGAGGTGATCCACGGCAAGGTGGTC CTCTTGAACCGCGCCCCCACCCTGCACCGCTTGGGCATCCAGGCCTTCCAGCCCGTCTTG GTGGAGGGGCAGTCCATCCAGCTCCACCCCCTGGTCTGCGAGGCCTTCAACGCCGACTTT GACGGGGACCAGATGGCCGTCCACGTCCCCCTCTCCTCCTTCGCCCAGGCCGAGGCCCGC ATCCAGATGCTCTCCGCCCACAACCTCCTCTCCCCGGCCTCCGGGGAGCCCCTGGCCAAG CCCAGCCGGGACATCATCCTGGGCCTCTACTACATCACCCAGGTGCGCAAGGAGAAGAAG GGGGCGGGCCTGGAGTTCGCCACCCCCGAGGAGGCCCTGGCCGCCCACGAGCGGGGAGAG GTGGCCCTGAACGCCCCCATCAAGGTGGCGGGCAGGGAGACCAGCGTGGGCCGGCTCAAG TACGTCTTCGCCAACCCCGACGAGGCCCTCCTCGCCGTGGCCCACGGCATCGTGGACCTG CAGGACGTGGTCACCGTCCGCTACATGGGCAAGCGGCTGGAGACGAGCCCGGGCCGCATC CTCTTCGCCCGCATCGTGGCCGAGGCGGTGGAGGACGAGAAGGTGGCCTGGGAGCTCATC CAGCTGGACGTGCCCCAGGAGAAGAACTCCCTCAAGGACCTGGTCTACCAGGCCTTCCTC CGCCTGGGGATGGAGAAGACCGCCAGGCTCCTGGACGCCCTCAAGTACTACGGCTTCACC TTCTCCACCACGAGCGGCATCACCATCGGCATTGACGACGCCGTGATCCCGGAGGAGAAG AAGCAGTACCTGGAGGAGGCCGACCGCAAGCTCCTCCAGATTGAGCAGGCCTACGAGATG GGCTTCCTCACCGACCGGGAGCGGTACGACCAGATCCTCCAGCTCTGGACCGAGACCACG GAGAAGGTCACCCAGGCGGTCTTCAAGAACTTTGAGGAGAACTACCCCTTCAACCCCCTC TACGTCATGGCCCAGTCCGGGGCCCGGGGCAACCCGCAGCAGATCCGCCAGCTCTGCGGC CTGCGCGGCCTCATGCAGAAGCCCTCGGGCGAGACCTTTGAGGTGCCGGTGCGCTCCTCC TTCCGCGAGGGCCTCACCGTCTTGGAGTACTTCATCTCCAGCCACGGGGCCCGTAAGGGC GGGGCGGACACCGCCCTCCGCACCGCCGACTCCGGCTACCTCACCCGCAAGCTCGTGGAC GTGACCCACGAGATCGTGGTGCGGGAGGCGGACTGCGGCACCACCAACTACATCTCCGTT CCCCTCTTCCAGCCCGACGAGGTGACCCGCTCCTTGCGCCTGAGGAAGCGCGCGGACATT GAGGCGGGCCTCTACGGGCGCGTCCTGGCCCGGGAGGTGGAGGTCCTGGGGGTGCGCCTC GAGGAGGGCCGCTACCTCTCCATGGACGACGTCCACCTCCTCATCAAGGCCGCCGAGGCC GGGGAGATCCAGGAGGTGCCCGTCCGCAGCCCCCTCACCTGCCAGACCCGCTACGGGGTC TGCCAGAAGTGCTACGGGTACGACCTCTCCATGGCCCGGCCCGTCTCCATCGGCGAGGCG GTGGGCATCGTGGCCGCCCAGTCCATCGGCGAGCCCGGCACCCAGCTCACCATGCGCACC TTCCACACGGGCGGCGTGGCCGGGGCCGCGGACATCACCCAGGGTCTGCCCCGCGTCATT GAGCTCTTTGAGGCCCGGCGCCCCAAGGCCAAGGCGGTGATCTCCGAGATTGACGGGGTG GTGCGCATTGAGGAGACGGAGGAGAAGCTCTCCGTCTTCGTGGAGTCCGAGGGCTTCTCC AAGGAGTACAAGCTCCCCAAGGAGGCGCGCCTTCTCGTCAAGGACGGGGACTACGTGGAG GCGGGCCAGCCCCTCACCCGCGGGGCCATTGACCCCCACCAGCTCTTGGAGGCCAAGGGC CCCGAGGCGGTGGAGCGCTACCTGGTGGAGGAGATCCAGAAGGTCTACCGGGCCCAGGGC GTGAAGCTGCACGACAAGCACATTGAGATCGTGGTCCGGCAGATGATGAAGTACGTGGAG GTCACCGACCCCGGGGACAGCCGCCTCCTCGAGGGCCAGGTCCTGGAGAAGTGGGACGTG GAGGCCCTGAACGAGAGGCTCATCGCCGAGGGCAAGACCCCGGTGGCCTGGAAGCCCCTC CTCATGGGGGTCACGAAGAGCGCCCTCTCCACCAAGAGCTGGCTCTCCGCCGCCAGCTTC CAGAACACCACCCACGTCCTCACCGAGGCGGCCATCGCCGGGAAGAAGGACGAGCTCATC GGCCTCAAGGAGAACGTCATCCTGGGCCGCCTGATCCCGGCGGGCACGGGTTCGGACTTC GTCCGCTTCACCCAGGTGGTGGACCAGAAGACCCTGAAGGCCATTGAGGAGGCCCGCAAG GAGGCGGTGGAGGCCAAGGAGCGGCCCGCCGCCCGGCGCGGGGTCAAGCGGGAGCAGCCC GGCAAGCAGGCTTAA PF04997 RNA_pol_Rpb1_1 PF00623 RNA_pol_Rpb1_2 PF04983 RNA_pol_Rpb1_3 PF05000 RNA_pol_Rpb1_4 PF04998 RNA_pol_Rpb1_5 component intracellular membrane-bound organelle component nucleus component organelle component membrane-bound organelle function transferase activity, transferring phosphorus-containing groups function nucleic acid binding function binding function DNA binding function catalytic activity function nucleotidyltransferase activity function DNA-directed RNA polymerase activity function transferase activity process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process metabolism process cellular metabolism process transcription BE0003369 DNA-directed RNA polymerase subunit omega Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown DNA-directed RNA polymerase subunit omega Involved in DNA-directed RNA polymerase activity Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) rpoZ Cytoplasmic None 4.96 11518.0 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) GenBank Gene Database AB083791 UniProtKB Q8RQE7 UniProt Accession RPOZ_THET8 EC 2.7.7.6 RNA polymerase omega subunit RNAP omega subunit Transcriptase omega chain >DNA-directed RNA polymerase omega chain MAEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNA VTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPVEREE >300 bp ATGGCGGAACCGGGCATTGACAAGCTCTTCGGCATGGTGGACTCCAAGTACCGGCTCACC GTGGTGGTGGCCAAAAGGGCGCAGCAGCTCCTCCGCCACGGCTTCAAGAACACGGTCTTG GAGCCGGAAGAGAGGCCCAAGATGCAGACCCTCGAGGGGCTTTTTGACGACCCCAACGCC GAGACCTGGGCCATGAAGGAGCTCCTCACGGGCCGGTTGGTCTTCGGGGAGAACCTGGTG CCCGAGGACCGGCTGCAAAAGGAGATGGAGCGGATCTACCCGGGGGAGCGAGAGGAGTAA PF01192 RNA_pol_Rpb6 function transferase activity function transferase activity, transferring phosphorus-containing groups function nucleic acid binding function DNA binding function nucleotidyltransferase activity function binding function DNA-directed RNA polymerase activity function catalytic activity process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process transcription process transcription, DNA-dependent process metabolism process cellular metabolism BE0003370 RNA polymerase sigma factor Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown RNA polymerase sigma factor Involved in catalytic activity TTHA0532 Cytoplasmic None 4.77 48525.0 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) GenBank Gene Database AP008226 UniProtKB Q5SKW1 UniProt Accession Q5SKW1_THET8 RpoD >RNA polymerase pricipal sigma factor MKKSKRKNAQAQEAQETEVLVQEEAEELPEFPEGEPDPDLEDPDLTLEDDLLDLPEEGEG LDLEEEEEDLPIPKISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLSEIT GLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRYLHIAREG EAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRFKFSTYAT WWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQLQQELGREPTYEEIAEAMGPGWD AKRVEETLKIAQEPVSLETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEELEKALSK LSEREAMVLKLRKGLIDGREHTLEEVGAFFGVTRERIRQIENKALRKLKYHESRTRKLRD FLD >1272 bp TTAGTCCAGGAAGTCCCTGAGCTTCCGCGTGCGGGACTCGTGGTACTTGAGCTTGCGGAG GGCCTTGTTCTCAATCTGCCGGATCCTTTCCCGGGTGACGCCGAAGAAGGCCCCCACCTC CTCCAGGGTGTGCTCCCGCCCGTCAATGAGCCCTTTCCGGAGCTTCAGGACCATGGCCTC GCGCTCGGAGAGCTTGGACAGGGCCTTCTCCAGCTCCTCGGAGAGGAGGCTCTGGGTGGC GGCGTCCACCGGGGAGGGGAGGTGCTCGTCGGGGATGAAGTCCCCGTAGAAGCTGTCCTT CTCGTCGCCGATGGGGGTCTCCAGGGAGACGGGCTCCTGGGCGATCTTGAGGGTTTCCTC CACCCGCTTGGCGTCCCAGCCCGGCCCCATGGCCTCGGCGATCTCCTCGTAGGTGGGTTC CCGGCCGAGCTCCTGCTGCAGCTGCCTTGCGGTGCGGGAGAGCTTGTTGATGGTCTCCAC CATGTGGACCGGGATGCGGATGGTGCGGGCCTGGTCGGCGATGGCCCGGTTGATGGCCTG CCGGATCCACCAGGTGGCGTAGGTGGAGAACTTGAAGCGCCGCTTGTACTCAAACTTCTC CACCGCCCGGATCAGGCCCTGGTTTCCCTCCTGGATGAGGTCCAGGAAGGAGAGGCCCCG CCCCGTGTACTTCTTGGCGATGGAGACCACGAGCCGGAGGTTGGCCTCAATGAGGTGCTG CCGGGCCGCCTCCCCTTCCCGGGCGATGTGGAGGTAGCGCTTGTGCTCCTTGGGGAGGCT TTTGAGCTTCTGGTCAATCTCCTCCACGGTCTTGGGGTCCAGGGTCTCCTTGAGGCCGGG GATGTGCCGCACCCGGGCCGAGCCCAGAATCTTGGCCCGGACCACCTCCCGGATGAGGTC GGGGTCAAGGCCGGTGATCTCGGAGAGCTTCTTGATGGCCTCCATCCCCTCCTCCACCTT CCGGGCGAGCTCCACCTCCTCCTCCAGGGTGAGGAGGGGGACCTGGCCGATCTCGTGCAG GTACTGGCGCACGGGGTCGGAGGTGGAGATCTTGGGGATGGGGAGGTCTTCTTCCTCCTC CTCCAGGTCCAGCCCCTCGCCCTCCTCGGGCAGGTCCAGGAGGTCGTCCTCCAGGGTGAG GTCCGGGTCCTCGAGGTCGGGGTCGGGCTCCCCCTCGGGGAACTCGGGGAGTTCCTCCGC CTCCTCCTGGACCAGGACCTCGGTCTCCTGGGCCTCCTGGGCCTGGGCGTTCTTGCGCTT GCTCTTCTTCAA PF00140 Sigma70_r1_2 PF04542 Sigma70_r2 PF04539 Sigma70_r3 PF04545 Sigma70_r4 function adenyl nucleotide binding function ATP binding function nucleic acid binding function transcription factor activity function transcription regulator activity function binding function DNA binding function transcription initiation factor activity function sigma factor activity function nucleotide binding function purine nucleotide binding process regulation of transcription process regulation of transcription, DNA-dependent process transcription process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process transcription, DNA-dependent process physiological process process regulation of biological process process metabolism process regulation of physiological process process transcription initiation process cellular metabolism process regulation of metabolism process regulation of cellular metabolism process regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism "

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