Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04785"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"Streptolydigin"
|
| rdf:type | |
| drugbank:description |
"
7229-50-7
experimental
Streptolydigin is an antibiotic which works by blocking nucleic acid chain elongation by binding to the polymerase, thus stopping RNA polymerase activity inside a cell. Specifically, it inhibits the assembly of the RNA polymerase II transcription complex and DNA polymerase III transcription. It is active against a number of gram positive bacteria.
This compound belongs to the beta amino acids and derivatives. These are amino acids having a (-NH2) group attached to the beta carbon atom.
Beta Amino Acids and Derivatives
Organic Compounds
Organic Acids and Derivatives
Carboxylic Acids and Derivatives
Amino Acids, Peptides, and Analogues
Bicyclic Monoterpenes
Pyrans
1,3-Dioxanes
Oxanes
Acryloyl Compounds
Enones
Pyrrolines
Tertiary Amines
Secondary Alcohols
Secondary Carboxylic Acid Amides
Polyamines
Carboxylic Acids
Enolates
Acetals
Epoxides
meta-dioxane
pyran
oxane
acryloyl-group
pyrroline
enone
secondary carboxylic acid amide
secondary alcohol
ketone
tertiary amine
carboxamide group
polyamine
carboxylic acid
ether
oxirane
enolate
acetal
amine
alcohol
carbonyl group
organonitrogen compound
Portamycin
Anti-Bacterial Agents
Enteric bacteria and other eubacteria
logP
1.98
ALOGPS
logS
-4.1
ALOGPS
Water Solubility
4.61e-02 g/l
ALOGPS
logP
3.54
ChemAxon
IUPAC Name
(2S)-2-[(2S)-4-[(2E,4E,6R)-6-[(1S,2S,5S,6S,7S)-1,6-dimethyl-8,9-dioxaspiro[bicyclo[3.3.1]nonane-2,2'-oxiran]-3-en-7-yl]-4-methylhepta-2,4-dienoyl]-5-hydroxy-1-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]-3-oxo-2,3-dihydro-1H-pyrrol-2-yl]-N-methylpropanamide
ChemAxon
Traditional IUPAC Name
streptolydigin
ChemAxon
Molecular Weight
600.6998
ChemAxon
Monoisotopic Weight
600.304681016
ChemAxon
SMILES
CNC(=O)[C@@H](C)[C@@H]1N([C@@H]2CC[C@H](O)[C@H](C)O2)C(O)=C(C(=O)\C=C\C(\C)=C\[C@@H](C)[C@@H]2O[C@]3(C)O[C@@H](C=C[C@]33CO3)[C@@H]2C)C1=O
ChemAxon
Molecular Formula
C32H44N2O9
ChemAxon
InChI
InChI=1S/C32H44N2O9/c1-16(14-17(2)28-18(3)23-12-13-32(15-40-32)31(6,42-23)43-28)8-9-22(36)25-27(37)26(19(4)29(38)33-7)34(30(25)39)24-11-10-21(35)20(5)41-24/h8-9,12-14,17-21,23-24,26,28,35,39H,10-11,15H2,1-7H3,(H,33,38)/b9-8+,16-14+/t17-,18+,19+,20+,21+,23+,24+,26+,28+,31+,32+/m1/s1
ChemAxon
InChIKey
InChIKey=UEFVDAXLJNYMAZ-ONVRBHABSA-N
ChemAxon
Polar Surface Area (PSA)
147.16
ChemAxon
Refractivity
169.64
ChemAxon
Polarizability
63.69
ChemAxon
Rotatable Bond Count
8
ChemAxon
H Bond Acceptor Count
10
ChemAxon
H Bond Donor Count
3
ChemAxon
pKa (strongest acidic)
4.25
ChemAxon
pKa (strongest basic)
-0.26
ChemAxon
Physiological Charge
-2
ChemAxon
Number of Rings
5
ChemAxon
Bioavailability
1
ChemAxon
MDDR-Like Rule
true
ChemAxon
PubChem Compound
6436180
PubChem Substance
46505558
ChemSpider
191238
PDB
STD
Wikipedia
Streptolydigin
"
|
| drugbank:drugCategory |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object