Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04207"

Predicate	Value (sorted: default)
rdfs:label	"N-(5-Amino-5-Carboxypentyl)Glutamic Acid"
rdf:type	drugbank:drugs
drugbank:description	" experimental This compound belongs to the alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. Alpha Amino Acids and Derivatives Organic Compounds Organic Acids and Derivatives Carboxylic Acids and Derivatives Amino Acids, Peptides, and Analogues Tricarboxylic Acids and Derivatives Amino Fatty Acids Polyols Polyamines Carboxylic Acids Dialkylamines Enolates Monoalkylamines polyol secondary aliphatic amine enolate polyamine carboxylic acid secondary amine amine primary amine primary aliphatic amine organonitrogen compound logP -2.8 ALOGPS logS -1.7 ALOGPS Water Solubility 5.25e+00 g/l ALOGPS logP -5.4 ChemAxon IUPAC Name (2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acid ChemAxon Traditional IUPAC Name saccharopine ChemAxon Molecular Weight 276.2863 ChemAxon Monoisotopic Weight 276.132136382 ChemAxon SMILES N[C@@H](CCCCN[C@@H](CCC(O)=O)C(O)=O)C(O)=O ChemAxon Molecular Formula C11H20N2O6 ChemAxon InChI InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/t7-,8-/m0/s1 ChemAxon InChIKey InChIKey=ZDGJAHTZVHVLOT-YUMQZZPRSA-N ChemAxon Polar Surface Area (PSA) 149.95 ChemAxon Refractivity 63.95 ChemAxon Polarizability 28.14 ChemAxon Rotatable Bond Count 11 ChemAxon H Bond Acceptor Count 8 ChemAxon H Bond Donor Count 5 ChemAxon pKa (strongest acidic) 1.44 ChemAxon pKa (strongest basic) 10.89 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon PubChem Compound 160556 PubChem Substance 46505056 PDB SHR SMP00719 2-aminoadipic 2-oxoadipic aciduria DB00142 L-Glutamic Acid DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid Q9UDR5 P49419 Q8N5Z0 P30084 Q16836 P24752 P52569 Q9BXI2 Q9P0Z9 Q92947 Q96HY7 P36957 P09622 SMP00186 Glutaric Aciduria Type III DB00142 L-Glutamic Acid DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid Q9UDR5 P49419 Q8N5Z0 P30084 Q16836 P24752 P52569 Q9BXI2 Q9P0Z9 Q02218 P36957 P09622 Q92947 SMP00037 Lysine Degradation DB00142 L-Glutamic Acid DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid Q9UDR5 P49419 Q8N5Z0 P30084 Q16836 P24752 P52569 Q9BXI2 Q9P0Z9 Q02218 P36957 P09622 Q92947 SMP00571 Pyridoxine dependency with seizures DB00142 L-Glutamic Acid DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid Q9UDR5 P49419 Q8N5Z0 P30084 Q16836 P24752 P52569 Q9BXI2 Q9P0Z9 Q02218 P36957 P09622 Q92947 SMP00527 Hyperlysinemia I, Familial DB00142 L-Glutamic Acid DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid Q9UDR5 P49419 Q8N5Z0 P30084 Q16836 P24752 P52569 Q9BXI2 Q9P0Z9 Q02218 P36957 P09622 Q92947 SMP00239 Saccharopinuria/Hyperlysinemia II DB00142 L-Glutamic Acid DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid Q9UDR5 P49419 Q8N5Z0 P30084 Q16836 P24752 P52569 Q9BXI2 Q9P0Z9 Q02218 P36957 P09622 Q92947 SMP00528 Hyperlysinemia II or Saccharopinuria DB00142 L-Glutamic Acid DB04207 N-(5-Amino-5-Carboxypentyl)Glutamic Acid Q9UDR5 P49419 Q8N5Z0 P30084 Q16836 P24752 P52569 Q9BXI2 Q9P0Z9 Q02218 P36957 P09622 Q92947 BE0000073 Alpha-aminoadipic semialdehyde synthase, mitochondrial Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Alpha-aminoadipic semialdehyde synthase, mitochondrial Amino acid transport and metabolism Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively AASS 7q31.3 Mitochondrion None 6.62 102133.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:17366 GenAtlas AASS GeneCards AASS GenBank Gene Database AF229180 GenBank Protein Database 7264724 UniProtKB Q9UDR5 UniProt Accession AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor EC 1.5.1.8 EC 1.5.1.9 LKR LKR/SDH LOR Saccharopine dehydrogenase >Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQ PSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANM GLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFM HIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPC EYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIA PYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTG GSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLY PYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTR RKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKL GFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGE LGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMN VMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTL LRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLK EAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRD SFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFS KEIYGPILERIKAEGIIYTTQSTIKP >2781 bp ATGCTGCAAGTACATAGGACTGGACTGGGCAGGCTGGGGGTCAGCCTCTCCAAGGGTCTT CACCACAAAGCTGTGTTGGCCGTCCGGAGGGAGGATGTGAACGCCTGGGAGAGAAGGGCC CCGCTAGCTCCCAAGCACATCAAAGGCATCACCAATCTGGGATACAAGGTCTTGATACAG CCTTCGAATCGGCGGGCCATTCATGATAAGGACTATGTCAAAGCTGGTGGCATTCTTCAG GAGGATATTTCTGAAGCTTGTCTAATTTTAGGAGTTAAAAGACCTCCAGAGGAAAAATTA ATGTCCAGGAAGACTTATGCATTTTTCTCCCACACAATAAAAGCTCAGGAGGCCAATATG GGCTTGTTGGATGAGATTCTAAAACAGGAAATTCGCCTTATTGATTATGAGAAAATGGTG GATCATAGAGGAGTACGGGTAGTGGCATTTGGACAGTGGGCTGGTGTGGCAGGAATGATC AACATTTTACATGGAATGGGTTTAAGGCTCCTTGCTTTGGGACATCACACACCTTTTATG CACATTGGCATGGCTCATAACTACAGGAATAGCAGTCAGGCTGTGCAAGCTGTCCGTGAT GCTGGCTATGAAATATCTTTGGGTTTGATGCCTAAGTCAATAGGACCCTTAACATTTGTG TTCACAGGAACTGGTAATGTTTCTAAGGGAGCCCAAGCAATCTTTAATGAGCTACCTTGT GAATATGTGGAGCCCCATGAATTAAAAGAAGTTTCCCAAACTGGAGACCTCAGAAAAGTG TATGGGACGGTGTTAAGTCGTCATCATCATCTTGTCAGGAAAACAGATGCTGTGTATGAT CCTGCAGAGTATGACAAACATCCGGAGCGCTACATAAGTCGTTTTAATACTGATATTGCA CCCTATACAACTTGCTTAATTAATGGAATCTACTGGGAACAAAACACTCCTCGCCTCCTA ACCCGCCAAGATGCTCAGAGTCTCCTGGCTCCGGGCAAGTTCTCACCTGCTGGTGTGGAA GGCTGCCCTGCATTACCACACAAACTCGTGGCAATATGTGACATTTCAGCTGACACAGGA GGGTCTATAGAGTTTATGACTGAGTGTACAACAATAGAGCATCCCTTTTGCATGTATGAT GCAGACCAGCATATTATTCATGACAGTGTTGAAGGCTCGGGGATCCTGATGTGTTCCATT GACAATTTGCCGGCACAGCTCCCAATTGAAGCTACAGAATGCTTTGGAGACATGCTTTAC CCTTATGTTGAAGAAATGATATTATCAGACGCGACACAGCCTCTTGAAAGTCAGAATTTT TCTCCTGTGGTGAGAGATGCAGTGATTACATCCAACGGTACATTACCTGATAAATATAAA TATATCCAGACACTCCGGGAGAGCAGGGAACGTGCTCAGTCACTTTCAATGGGCACCAGG AGAAAGGTTTTGGTTCTTGGATCTGGCTACATATCTGAGCCTGTATTAGAATATTTATCA AGAGATGGCAATATAGAAATAACAGTAGGATCTGACATGAAGAATCAAATTGAACAGTTA GGCAAGAAATATAATATTAATCCTGTTAGCATGGACATTTGTAAACAAGAAGAGAAGCTG GGCTTCTTGGTGGCAAAACAGGATCTTGTCATCAGCTTGTTGCCTTATGTATTGCACCCT CTTGTGGCCAAGGCCTGCATCACAAACAAAGTTAACATGGTCACTGCAAGCTACATCACA CCAGCACTAAAAGAATTGGAAAAGAGTGTGGAAGATGCTGGCATCACAATCATTGGTGAA TTGGGATTGGACCCTGGTCTGGATCACATGTTAGCAATGGAAACAATAGATAAAGCCAAG GAAGTGGGAGCCACGATTGAATCATATATTTCCTACTGTGGTGGGCTTCCAGCCCCTGAA CATTCAAACAATCCATTGAGATATAAATTTAGCTGGAGTCCAGTGGGAGTTTTGATGAAT GTAATGCAGTCTGCCACCTATCTGCTCGATGGAAAGGTTGTGAATGTTGCAGGAGGCATC TCCTTTCTTGATGCCGTTACGTCCATGGATTTTTTTCCAGGATTAAATTTGGAAGGCTAT CCTAACAGAGACAGTACGAAATATGCTGAGATTTATGGCATTTCTTCTGCTCACACTTTG TTGCGGGGGACACTGAGATATAAGGGATATATGAAAGCTTTGAATGGATTTGTAAAATTA GGTCTTATAAACAGAGAAGCGCTTCCTGCCTTTAGACCTGAGGCCAACCCTCTCACCTGG AAACAACTCCTCTGTGACCTAGTTGGGATTTCACCCTCCTCTGAGCATGATGTGTTGAAG GAAGCTGTTCTTAAGAAACTAGGAGGAGACAATACCCAGTTGGAGGCTGCTGAATGGTTG GGCTTACTTGGGGATGAACAAGTTCCTCAGGCAGAGTCCATTCTGGATGCCCTCTCCAAG CATTTGGTCATGAAGCTTTCCTATGGTCCTGAAGAAAAAGATATGATTGTGATGAGAGAC AGCTTTGGAATCAGACATCCTTCTGGACATTTAGAACATAAAACGATTGATCTTGTGGCT TATGGGGACATCAATGGCTTTTCAGCCATGGCTAAAACCGTGGGGTTACCCACCGCCATG GCAGCCAAAATGTTGCTTGATGGTGAAATTGGAGCCAAAGGCCTAATGGGGCCCTTTTCA AAGGAGATCTATGGACCAATATTGGAGCGAATTAAAGCAGAAGGCATTATATATACTACA CAGAGTACAATTAAACCATAA PF01262 AlaDh_PNT_C PF05222 AlaDh_PNT_N PF03435 Saccharop_dh function oxidoreductase activity function catalytic activity process metabolism process cellular metabolism process generation of precursor metabolites and energy process electron transport process physiological process "
owl:sameAs	drug:L-Glutamic Acid drug:N-(5-Amino-5-Carboxypentyl)Glutamic Acid drug:EXPT02906

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 2 triples

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