Resource Alpha-ketoisovalerate

Predicate	Value (sorted: none)
rdf:type	drugbank:drugs
owl:sameAs	drug:Alpha-ketoisovalerate
owl:sameAs	drug:2-Oxo-4-Methylpentanoic Acid
owl:sameAs	drug:Pyridoxal
rdfs:label	"Alpha-ketoisovalerate"
drugbank:description	" 759-05-7 experimental This compound belongs to the alpha keto-acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon. Alpha Keto-Acids and Derivatives Organic Compounds Organic Acids and Derivatives Keto-Acids and Derivatives Alpha Keto-Acids and Derivatives Ketones Polyamines Enolates Carboxylic Acids Keto Acids and Derivatives ketone enolate polyamine carboxylic acid carboxylic acid derivative carbonyl group 2-Keto-3-methylbutyric acid 2-Ketovaline 2-Oxo-3-methylbutanoate 2-Oxoisopentanoate 2-Oxoisovalerate 3-Methyl-2-oxobutanoate 3-Methyl-2-oxobutanoic acid 3-Methyl-2-oxobutyric acid alpha-Ketovaline logP 0.49 ALOGPS logS -0.59 ALOGPS Water Solubility 3.02e+01 g/l ALOGPS logP 1.31 ChemAxon IUPAC Name 3-methyl-2-oxobutanoic acid ChemAxon Traditional IUPAC Name Î±-ketoisovalerate ChemAxon Molecular Weight 116.1152 ChemAxon Monoisotopic Weight 116.047344122 ChemAxon SMILES CC(C)C(=O)C(O)=O ChemAxon Molecular Formula C5H8O3 ChemAxon InChI InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8) ChemAxon InChIKey InChIKey=QHKABHOOEWYVLI-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 54.37 ChemAxon Refractivity 27.19 ChemAxon Polarizability 11.04 ChemAxon Rotatable Bond Count 2 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 1 ChemAxon pKa (strongest acidic) 3.37 ChemAxon pKa (strongest basic) -9.7 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Melting Point 31.5 Â°C PhysProp Boiling Point 170.5 Â°C PhysProp ChEBI 16530 PubChem Compound 49 PubChem Substance 46508074 KEGG Compound C00141 PDB KIV SMP00137 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00138 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00522 3-hydroxyisobutyric aciduria DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00141 3-Methylglutaconic Aciduria Type IV DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00139 3-Methylglutaconic Aciduria Type I DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00521 3-hydroxyisobutyric acid dehydrogenase deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00237 3-Methylcrotonyl Coa Carboxylase Deficiency Type I DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00140 3-Methylglutaconic Aciduria Type III DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00236 Propionic Acidemia DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00524 Isovaleric acidemia DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00200 Methylmalonic Aciduria DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00238 Isovaleric Aciduria DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00032 Valine, Leucine and Isoleucine Degradation DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00173 Beta-Ketothiolase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00523 Isobutyryl-coa dehydrogenase deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00384 Methylmalonate Semialdehyde Dehydrogenase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00199 Maple Syrup Urine Disease DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 BE0001822 3-methyl-2-oxobutanoate hydroxymethyltransferase Neisseria meningitidis serogroup B (strain MC58) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown 3-methyl-2-oxobutanoate hydroxymethyltransferase Coenzyme transport and metabolism 5,10-methylenetetrahydrofolate + 3-methyl-2- oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate panB None 6.39 27740.0 Neisseria meningitidis serogroup B (strain MC58) GenBank Gene Database AE002098 GenBank Protein Database 7226107 UniProtKB Q9JZW6 UniProt Accession PANB_NEIMB EC 2.1.2.11 Ketopantoate hydroxymethyltransferase >3-methyl-2-oxobutanoate hydroxymethyltransferase MITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSL RDMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAE TTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMEC VLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQA AVRAYVAEVKAKTFPAAEHIFAD >792 bp ATGATTACTGTGAACACACTGCAAAAAATGAAGGCGGCGGGCGAAAAAATCGCTATGCTG ACCGCTTACGAATCCAGTTTTGCCGCGCTGATGGACGATGCCGGCGTGGAAATGCTGCTG GTCGGCGATTCTTTGGGGATGGCGGTTCAGGGGCGGAAATCGACGCTGCCCGTCAGCCTG CGCGATATGTGTTATCACACCGAATGTGTAGCACGCGGTGCAAAAAATGCGATGATTGTC AGCGATTTGCCGTTTGGTGCATATCAGCAGAGTAAGGAGCAGGCGTTTGCCGCCGCCGCC GAACTGATGGCTGCCGGCGCGCATATGGTTAAACTCGAAGGCGGCGTGTGGATGGCGGAA ACGACTGAATTTTTGCAAATGCGCGGTATTCCGGTTTGTGCGCACATCGGTCTGACCCCG CAATCCGTGTTTGCCTTCGGCGGATATAAAGTTCAGGGGCGCGGCGGCAAGGCGCAGGCG TTGCTTAACGATGCCAAGGCGCATGACGATGCGGGGGCGGCGGTCGTGCTGATGGAGTGC GTACTGGCGGAACTGGCAAAAAAGGTAACTGAAACTGTTTCCTGTCCGACCATCGGCATC GGCGCGGGTGCGGATTGCGACGGGCAGGTTTTGGTGATGCACGATATGCTCGGCATTTTC CCGGGTAAGACGGCGAAATTCGTCAAAAACTTTATGCAGGGGCATGATAGTGTTCAAGCG GCGGTTCGGGCGTATGTTGCCGAAGTCAAAGCCAAAACCTTCCCTGCTGCGGAACATATT TTTGCAGATTGA PF02548 Pantoate_transf function methyltransferase activity function glycine hydroxymethyltransferase activity function hydroxymethyl-, formyl- and related transferase activity function catalytic activity function 3-methyl-2-oxobutanoate hydroxymethyltransferase activity function transferase activity function transferase activity, transferring one-carbon groups process cofactor metabolism process coenzyme metabolism process coenzyme biosynthesis process physiological process process pantothenate biosynthesis process metabolism process cellular metabolism BE0001833 Deacetoxycephalosporin C synthase Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Deacetoxycephalosporin C synthase Involved in iron ion binding Catalyzes the step from penicillin N to deacetoxy- cephalosporin C cefE None 4.94 34556.0 Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602) GenBank Gene Database M32324 GenBank Protein Database 153205 UniProtKB P18548 UniProt Accession CEFE_STRC2 DAOCS EC 1.14.20.1 Expandase >Deacetoxycephalosporin C synthetase MDTTVPTFSLAELQQGLHQDEFRRCLRDKGLFYLTDCGLTDTELKSAKDLVIDFFEHGSE AEKRAVTSPVPTMRRGFTGLESESTAQITNTGSYSDYSMCYSMGTADNLFPSGDFERIWT QYFDRQYTASRAVAREVLRATGTEPDGGVEAFLDCEPLLRFRYFPQVPEHRSAEEQPLRM APHYDLSMVTLIQQTPCANGFVSLQAEVGGAFTDLPYRPDAVLVFCGAIATLVTGGQVKA PRHHVAAPRRDQIAGSSRTSSVFFLRPNADFTFSVPLARECGFDVSLDGETATFQDWIGG NYVNIRRTSKA >936 bp ATGGACACGACGGTGCCCACCTTCAGCCTGGCCGAACTCCAGCAGGGCCTGCACCAGGAC GAGTTCCGCAGGTGTCTGAGGGACAAGGGCCTCTTCTATCTGACGGACTGCGGTCTGACC GACACCGAGCTGAAGTCGGCCAAGGACCTCGTCATCGACTTCTTCGAGCACGGCAGCGAG GCGGAGAAGCGCGCCGTCACCTCGCCCGTCCCCACCATGCGCCGCGGCTTCACCGGGCTG GAGTCGGAGAGCACCGCCCAGATCACCAATACCGGCAGCTACTCCGACTACTCGATGTGC TACTCGATGGGCACCGCGGACAACCTCTTCCCGTCCGGTGACTTCGAGCGGATCTGGACC CAGTACTTCGACCGCCAGTACACCGCCTCCCGCGCGGTCGCCCGGGAGGTCCTGCGGGCG ACCGGGACCGAGCCCGACGGCGGGGTCGAGGCCTTCCTCGACTGCGAGCCGCTGCTGCGG TTCCGCTACTTCCCGCAGGTCCCCGAGCACCGCAGCGCCGAGGAGCAGCCCCTGCGGATG GCGCCGCACTACGACCTGTCGATGGTCACCCTCATCCAGCAGACACCCTGCGCCAACGGC TTCGTCAGCCTCCAGGCCGAGGTCGGCGGCGCGTTCACGGACCTGCCCTACCGTCCGGAC GCCGTCCTCGTCTTCTGCGGCGCCATCGCGACCCTGGTGACCGGCGGCCAGGTCAAGGCC CCCCGGCACCATGTCGCGGCCCCCCGCAGGGACCAGATAGCGGGCAGCAGCCGCACCTCC AGTGTGTTCTTCCTCCGTCCCAACGCGGACTTCACCTTCTCCGTCCCGCTGGCGCGCGAG TGCGGCTTCGATGTCAGCCTGGACGGCGAGACCGCCACGTTCCAGGATTGGATCGGGGGC AACTACGTGAACATCCGCCGCACATCCAAGGCATAG PF03171 2OG-FeII_Oxy function cation binding function transition metal ion binding function iron ion binding function binding function catalytic activity function oxidoreductase activity function ion binding process biosynthesis process physiological process process metabolism BE0001742 2-isopropylmalate synthase Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown 2-isopropylmalate synthase Amino acid transport and metabolism Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA None 4.79 70114.0 Mycobacterium tuberculosis GenBank Gene Database U88526 GenBank Protein Database 1850985 UniProtKB P96420 UniProt Accession LEU1_MYCTU Alpha-IPM synthetase Alpha-isopropylmalate synthase EC 2.3.3.13 >2-isopropylmalate synthase MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR >1935 bp GTGACAACTTCTGAATCGCCCGACGCCTATACCGAGTCGTTTGGGGCCCACACCATCGTG AAACCCGCCGGCCCACCTCGCGTCGGTCAGCCCTCGTGGAATCCGCAGCGAGCCTCGTCG ATGCCGGTCAACCGCTACCGGCCGTTCGCCGAGGAGGTCGAGCCCATCCGGCTGAGAAAC CGCACGTGGCCTGATCGCGTCATCGATCGTGCGCCGCTGTGGTGCGCGGTCGACTTACGC GATGGCAACCAGGCGCTGATCGACCCGATGAGCCCGGCCCGCAAGCGCCGCATGTTCGAC CTGCTGGTCCGGATGGGCTACAAGGAGATTGAGGTGGGGTTCCCCTCGGCCAGCCAGACC GACTTCGACTTCGTCAGAGAGATCATCGAGCAGGGCGCCATTCCCGACGACGTCACCATC CAGGTGCTCACCCAATGCCGTCCCGAGCTGATCGAGCGCACCTTCCAGGCGTGTTCGGGC GCACCCCGGGCCATCGTGCACTTCTACAACTCGACGTCAATCCTGCAGCGCCGCGTGGTC TTTCGCGCCAACCGGGCTGAGGTGCAGGCCATCGCGACAGATGGGGCGCGCAAGTGCGTC GAGCAGGCCGCCAAATACCCGGGCACGCAGTGGCGATTCGAGTACTCCCCGGAGTCCTAC ACCGGCACCGAACTGGAATACGCCAAACAGGTGTGCGACGCCGTCGGCGAGGTCATTGCG CCGACGCCGGAGCGCCCGATCATCTTCAACCTGCCCGCCACGGTGGAGATGACGACGCCC AATGTCTACGCCGACTCGATCGAGTGGATGAGCCGCAACCTAGCCAACCGGGAGTCGGTC ATCCTGAGCCTGCACCCGCACAATGACCGCGGAACCGCCGTCGCCGCAGCGGAATTGGGT TTCGCGGCCGGGGCTGATCGGATCGAGGGCTGCCTGTTCGGCAACGGCGAGCGCACCGGC AACGTGTGCCTGGTCACGCTGGGACTCAACCTGTTCTCCCGAGGTGTGGACCCGCAGATC GACTTCTCCAATATTGACGAGATCCGGCGCACGGTGGAGTACTGCAACCAGCTGCCGGTG CACGAACGTCACCCCTATGGCGGCGACCTGGTGTACACCGCGTTCTCCGGTAGCCACCAG GACGCCATCAACAAGGGCCTAGACGCGATGAAGCTGGATGCGGATGCCGCCGACTGTGAC GTCGACGACATGCTGTGGCAGGTGCCGTATCTGCCCATCGACCCGCGCGATGTCGGGCGC ACCTACGAGGCGGTGATCCGGGTCAACTCGCAGTCCGGCAAGGGCGGCGTGGCCTACATC ATGAAGACCGACCACGGCCTTTCCCTGCCGCGGCGGCTGCAGATCGAGTTTTCCCAGGTA ATCCAGAAGATCGCAGAGGGTACAGCAGGCGAGGGTGGCGAGGTCTCGCCCAAGGAGATG TGGGATGCGTTCGCCGAGGAGTATCTGGCCCCGGTGCGGCCTTTGGAGCGGATAAGGCAA CATGTGGACGCTGCCGACGACGACGGCGGCACGACCAGCATCACGGCGACCGTCAAGATC AACGGCGTGGAGACCGAGATCAGCGGGTCCGGTAACGGTCCGTTGGCCGCGTTCGTCCAT GCGCTGGCCGATGTCGGGTTTGACGTGGCCGTGCTGGACTACTACGAGCACGCGATGAGC GCCGGCGACGACGCTCAGGCCGCCGCGTATGTGGAGGCCTCCGTGACGATCGCGAGCCCG GCGCAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGATCGCGAGCCCGGCG CAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGAGTAAGACGGTGTGGGGT GTCGGTATCGCACCGTCAATCACCACCGCGTCGCTGCGCGCCGTGGTGTCGGCGGTCAAC CGGGCGGCACGCTAG PF00682 HMGL-like PF08502 LeuA_dimer function 2-isopropylmalate synthase activity function transferase activity function transferase activity, transferring acyl groups function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer function catalytic activity process leucine metabolism process metabolism process leucine biosynthesis process cellular metabolism process amino acid metabolism process amino acid and derivative metabolism process organic acid metabolism process carboxylic acid metabolism process branched chain family amino acid metabolism process physiological process BE0000721 Branched-chain-amino-acid aminotransferase, mitochondrial Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Branched-chain-amino-acid aminotransferase, mitochondrial Amino acid transport and metabolism Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids BCAT2 19q13 Isoform A:Mitochondrion. Isoform B:Cytoplasm None 8.82 44288.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:977 GenAtlas BCAT2 GeneCards BCAT2 GenBank Gene Database U68418 GenBank Protein Database 2342862 UniProtKB O15382 UniProt Accession BCAT2_HUMAN BCAT(m) Branched-chain-amino-acid aminotransferase, mitochondrial precursor EC 2.6.1.42 Placental protein 18 PP18 >Branched-chain-amino-acid aminotransferase, mitochondrial precursor MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP TMENGPELILRFQKELKEIQYGIRAHEWMFPV >1179 bp ATGGCCGCAGCCGCTCTGGGGCAGATCTGGGCACGAAAGCTTCTCTCTGTCCCTTGGCTT CTGTGTGGTCCCAGAAGATATGCCTCCTCCAGTTTCAAGGCTGCAGACCTGCAGCTGGAA ATGACACAGAAGCCTCATAAGAAGCCTGGCCCCGGCGAGCCCCTGGTGTTTGGGAAGACA TTTACCGACCACATGCTGATGGTGGAATGGAATGACAAGGGCTGGGGCCAGCCCCGAATC CAGCCCTTCCAGAACCTCACGCTGCACCCAGCCTCCTCCAGCCTCCACTACTCCCTGCAG CTGTTTGAGGGCATGAAGGCGTTCAAAGGCAAAGACCAGCAGGTGCGCCTCTTCCGCCCC TGGCTCAACATGGACCGGATGCTGCGCTCAGCCATGCGCCTGTGCCTGCCGAGTTTCGAC AAGCTGGAGTTGCTGGAGTGCATCCGCCGGCTCATCGAAGTGGACAAGGACTGGGTCCCC GATGCCGCCGGCACCAGCCTCTATGTGCGGCCTGTGCTCATTGGGAACGAGCCCTCGCTG GGTGTCAGCCAGCCCAGGCGCGCGCTCCTGTTCGTCATTCTCTGCCCAGTGGGTGCCTAC TTCCCTGGAGGCTCCGTGACCCCGGTCTCCCTCCTGGCCGACCCAGCCTTCATCCGGGCC TGGGTGGGCGGGGTCGGCAACTACAAGTTAGGTGGGAATTATGGGCCCACCGTGTTAGTG CAACAGGAGGCACTCAAGCGGGGCTGTGAACAGGTCCTCTGGCTGTATGGGCCCGACCAC CAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGGACCCACGAAGATGGGGTG CTGGAGCTGGTGACGCCCCCGCTGAATGGTGTTATCCTGCCTGGAGTGGTCAGACAGAGT CTACTGGACATGGCTCAGACCTGGGGTGAGTTCCGGGTGGTGGAGCGCACGATCACCATG AAGCAGTTGCTGCGGGCCTTGGAGGAGGGCCGCGTGCGGGAAGTCTTTGGCTCGGGCACC GCTTGCCAGGTCTGCCCAGTGCACCGAATCCTGTACAAAGACAGGAACCTCCATATTCCC ACCATGGAAAATGGGCCTGAGCTGATCCTCCGCTTCCAGAAGGAGCTGAAGGAGATCCAG TACGGAATCAGAGCCCACGAGTGGATGTTCCCGGTGTGA PF01063 Aminotran_4 function transferase activity function transferase activity, transferring nitrogenous groups function transaminase activity function branched-chain-amino-acid transaminase activity function catalytic activity process branched chain family amino acid metabolism process physiological process process metabolism process cellular metabolism process amino acid metabolism process amino acid and derivative metabolism BE0000440 Monocarboxylate transporter 2 Human inhibitor # Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10417314 unknown Monocarboxylate transporter 2 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter SLC16A7 12q13 Cell membrane; multi-pass membrane protein 16-36 60-80 90-110 116-136 149-169 174-194 247-267 283-303 313-333 339-359 374-394 407-427 9.68 52187.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10928 GenAtlas SLC16A7 GeneCards SLC16A7 GenBank Gene Database AF058056 GenBank Protein Database 3047402 UniProtKB O60669 UniProt Accession MOT2_HUMAN MCT 2 Solute carrier family 16 member 7 >Monocarboxylate transporter 2 MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAW ISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFIT GLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLI LGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFS LFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSV GLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFE TLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW LLIGNAINYRLLAKERKEENARQKSRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI >1437 bp ATGCCACCAATGCCAAGTGCCCCACCTGTGCATCCACCTCCAGATGGAGGATGGGGTTGG ATTGTGGTTGGAGCAGCTTTTATCTCCATTGGATTTTCCTATGCATTCCCCAAAGCTGTC ACCGTATTCTTCAAAGAAATTCAGCAAATATTCCACACTACCTACAGTGAAATAGCATGG ATTTCATCCATTATGCTGGCTGTTATGTACGCAGGAGGTCCTGTAAGTAGTGTTTTGGTG AATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATG GTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACA GGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTAT AGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCA TTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATT TTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCC AATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCA AAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCC CTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGT TTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTAC TCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTA GGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCA ATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTG GTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAA ACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATT GTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACT GGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGG CTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAAT GCAAGGCAGAAGTCCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTT AACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAA PF07690 MFS_1 component cell component intrinsic to membrane component integral to membrane component membrane function transporter activity function monocarboxylate porter activity function organic acid transporter activity function carboxylic acid transporter activity function monocarboxylic acid transporter activity process transport process organic anion transport process ion transport process anion transport process physiological process process cellular physiological process BE0000669 Monocarboxylate transporter 1 Human inhibitor # Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW: Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J. 1998 Jul 1;333 ( Pt 1):167-74. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9639576 unknown Monocarboxylate transporter 1 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate SLC16A1 1p12 Cell membrane; multi-pass membrane protein 16-36 60-80 87-107 112-132 144-164 167-187 263-283 299-319 329-349 354-374 390-410 423-443 8.82 53959.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10922 GenAtlas SLC16A1 GeneCards SLC16A1 GenBank Gene Database L31801 GenBank Protein Database 561722 UniProtKB P53985 UniProt Accession MOT1_HUMAN MCT 1 Solute carrier family 16 member 1 >Monocarboxylate transporter 1 MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA AESPDQKDTEGGPKEEESPV >1503 bp ATGCCACCAGCAGTTGGAGGTCCAGTTGGATACACCCCCCCAGATGGAGGCTGGGGCTGG GCAGTGGTAATTGGAGCTTTCATTTCCATCGGCTTCTCTTATGCATTTCCCAAATCAATT ACTGTCTTCTTCAAAGAGATTGAAGGTATATTCCATGCCACCACCAGCGAAGTGTCATGG ATATCCTCCATAATGTTGGCTGTCATGTATGGTGGAGGTCCTATCAGCAGTATCCTGGTG AATAAATATGGAAGTCGTATAGTCATGATTGTTGGTGGCTGCTTGTCAGGCTGTGGCTTG ATTGCAGCTTCTTTCTGTAACACCGTACAGCAACTATACGTCTGTATTGGAGTCATTGGA GGTCTTGGGCTTGCCTTCAACTTGAATCCAGCTCTGACCATGATTGGCAAGTATTTCTAC AAGAGGCGACCATTGGCCAACGGACTGGCCATGGCAGGCAGCCCTGTGTTCCTCTGTACT CTGGCCCCCCTCAATCAGGTTTTCTTCGGTATCTTTGGATGGAGAGGAAGCTTTCTAATT CTTGGGGGCTTGCTACTAAACTGCTGTGTTGCTGGAGCCCTCATGCGACCAATCGGGCCC AAGCCAACCAAGGCAGGGAAAGATAAGTCTAAAGCATCCCTTGAGAAAGCTGGAAAATCT GGTGTGAAAAAAGATCTGCATGATGCAAATACAGATCTTATTGGAAGACACCCTAAACAA GAGAAACGATCAGTCTTCCAAACAATTAATCAGTTCCTGGACTTAACCCTATTCACCCAC AGAGGCTTTTTGCTATACCTCTCTGGAAATGTGATCATGTTTTTTGGACTCTTTGCACCT TTGGTGTTTCTTAGTAGTTATGGGAAGAGTCAGCATTATTCTAGTGAGAAGTCTGCCTTC CTTCTTTCCATTCTGGCTTTTGTTGACATGGTAGCCCGACCATCTATGGGACTTGTAGCC AACACAAAGCCAATAAGACCTCGAATTCAGTATTTCTTTGCGGCTTCCGTTGTTGCAAAT GGAGTGTGTCATATGCTAGCACCTTTATCCACTACCTATGTTGGATTCTGTGTCTATGCG GGATTCTTTGGATTTGCCTTCGGGTGGCTCAGCTCCGTATTGTTTGAAACATTGATGGAC CTTGTTGGACCCCAGAGGTTCTCCAGCGCTGTGGGATTGGTGACCATTGTGGAATGCTGT CCTGTCCTCCTGGGGCCACCACTTTTAGGTCGGCTCAATGACATGTATGGAGACTACAAA TACACATACTGGGCATGTGGCGTCGTCCTAATTATTTCAGGTATCTATCTCTTCATTGGC ATGGGCATCAATTATCGACTTTTGGCAAAAGAACAGAAAGCAAACGAGCAGAAAAAGGAA AGTAAAGAGGAAGAGACCAGTATAGATGTTGCTGGGAAGCCAAATGAAGTTACCAAAACA GCAGAATCTCCGGACCAGAAAGACACAGAAGGAGGGCCCAAGGAGGAGGAAAGTCCAGTC TGA PF07690 MFS_1 component intrinsic to membrane component integral to membrane component membrane component cell function organic acid transporter activity function carboxylic acid transporter activity function monocarboxylic acid transporter activity function transporter activity function monocarboxylate porter activity process ion transport process anion transport process physiological process process cellular physiological process process transport process organic anion transport BE0000449 Monocarboxylate transporter 4 Human substrate # Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11101640 unknown Monocarboxylate transporter 4 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate SLC16A3 17q25 Cell membrane; multi-pass membrane protein 18-38 62-82 85-105 110-130 150-170 180-200 228-248 265-285 295-315 318-338 352-372 385-405 8.03 49470.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10924 GenAtlas SLC16A3 GeneCards SLC16A3 GenBank Gene Database U81800 GenBank Protein Database 2463634 UniProtKB O15427 UniProt Accession MOT4_HUMAN MCT 3 MCT 4 Solute carrier family 16 member 3 >Monocarboxylate transporter 4 MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV >1398 bp ATGGGAGGGGCCGTGGTGGACGAGGGCCCCACAGGCGTCAAGGCCCCTGACGGCGGCTGG GGCTGGGCCGTGCTCTTCGGCTGTTTCGTCATCACTGGCTTCTCCTACGCCTTCCCCAAG GCCGTCAGTGTCTTCTTCAAGGAGCTCATACAGGAGTTTGGGATCGGCTACAGCGACACA GCCTGGATCTCCTCCATCCTGCTGGCCATGCTCTACGGGACAGGTCCGCTCTGCAGTGTG TGCGTGAACCGCTTTGGCTGCCGGCCCGTCATGCTTGTGGGGGGTCTCTTTGCGTCGCTG GGCATGGTGGCTGCGTCCTTTTGCCGGAGCATCATCCAGGTCTACCTCACCACTGGGGTC ATCACGGGGTTGGGTTTGGCACTCAACTTCCAGCCCTCGCTCATCATGCTGAACCGCTAC TTCAGCAAGCGGCGCCCCATGGCCAACGGGCTGGCGGCAGCAGGTAGCCCTGTCTTCCTG TGTGCCCTGAGCCCGCTGGGGCAGCTGCTGCAGGACCGCTACGGCTGGCGGGGCGGCTTC CTCATCCTGGGCGGCCTGCTGCTCAACTGCTGCGTGTGTGCCGCACTCATGAGGCCCCTG GTGGTCACGGCCCAGCCGGGCTCGGGGCCGCCGCGACCCTCCCGGCGCCTGCTAGACCTG AGCGTCTTCCGGGACCGCGGCTTTGTGCTTTACGCCGTGGCCGCCTCGGTCATGGTGCTG GGGCTCTTCGTCCCGCCCGTGTTCGTGGTGAGCTACGCCAAGGACCTGGGCGTGCCCGAC ACCAAGGCCGCCTTCCTGCTCACCATCCTGGGCTTCATTGACATCTTCGCGCGGCCGGCC GCGGGCTTCGTGGCGGGGCTTGGGAAGGTGCGGCCCTACTCCGTCTACCTCTTCAGCTTC TCCATGTTCTTCAACGGCCTCGCGGACCTGGCGGGCTCTACGGCGGGCGACTACGGCGGC CTCGTGGTCTTCTGCATCTTCTTTGGCATCTCCTACGGCATGGTGGGGGCCCTGCAGTTC GAGGTGCTCATGGCCATCGTGGGCACCCACAAGTTCTCCAGTGCCATTGGCCTGGTGCTG CTGATGGAGGCGGTGGCCGTGCTCGTCGGGCCCCCTTCGGGAGGCAAACTCCTGGATGCG ACCCACGTCTACATGTACGTGTTCATCCTGGCGGGGGCCGAGGTGCTCACCTCCTCCCTG ATTTTGCTGCTGGGCAACTTCTTCTGCATTAGGAAGAAGCCCAAAGAGCCACAGCCTGAG GTGGCGGCCGCGGAGGAGGAGAAGCTCCACAAGCCTCCTGCAGACTCGGGGGTGGACTTG CGGGAGGTGGAGCATTTCCTGAAGGCTGAGCCTGAGAAAAACGGGGAGGTGGTTCACACC CCGGAAACAAGTGTCTGA PF07690 MFS_1 component cell component intrinsic to membrane component integral to membrane component membrane function monocarboxylic acid transporter activity function transporter activity function monocarboxylate porter activity function organic acid transporter activity function carboxylic acid transporter activity process transport process organic anion transport process ion transport process anion transport process physiological process process cellular physiological process "
owl:sameAs	drug:Biotin
owl:sameAs	drug:L-Glutamic Acid
owl:sameAs	drug:Succinic acid
owl:sameAs	drug:EXPT01974
owl:sameAs	drug:L-Isoleucine
owl:sameAs	drug:L-Valine

" 759-05-7 experimental This compound belongs to the alpha keto-acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon. Alpha Keto-Acids and Derivatives Organic Compounds Organic Acids and Derivatives Keto-Acids and Derivatives Alpha Keto-Acids and Derivatives Ketones Polyamines Enolates Carboxylic Acids Keto Acids and Derivatives ketone enolate polyamine carboxylic acid carboxylic acid derivative carbonyl group 2-Keto-3-methylbutyric acid 2-Ketovaline 2-Oxo-3-methylbutanoate 2-Oxoisopentanoate 2-Oxoisovalerate 3-Methyl-2-oxobutanoate 3-Methyl-2-oxobutanoic acid 3-Methyl-2-oxobutyric acid alpha-Ketovaline logP 0.49 ALOGPS logS -0.59 ALOGPS Water Solubility 3.02e+01 g/l ALOGPS logP 1.31 ChemAxon IUPAC Name 3-methyl-2-oxobutanoic acid ChemAxon Traditional IUPAC Name Î±-ketoisovalerate ChemAxon Molecular Weight 116.1152 ChemAxon Monoisotopic Weight 116.047344122 ChemAxon SMILES CC(C)C(=O)C(O)=O ChemAxon Molecular Formula C5H8O3 ChemAxon InChI InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8) ChemAxon InChIKey InChIKey=QHKABHOOEWYVLI-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 54.37 ChemAxon Refractivity 27.19 ChemAxon Polarizability 11.04 ChemAxon Rotatable Bond Count 2 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 1 ChemAxon pKa (strongest acidic) 3.37 ChemAxon pKa (strongest basic) -9.7 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Melting Point 31.5 Â°C PhysProp Boiling Point 170.5 Â°C PhysProp ChEBI 16530 PubChem Compound 49 PubChem Substance 46508074 KEGG Compound C00141 PDB KIV SMP00137 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00138 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00522 3-hydroxyisobutyric aciduria DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00141 3-Methylglutaconic Aciduria Type IV DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00139 3-Methylglutaconic Aciduria Type I DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00521 3-hydroxyisobutyric acid dehydrogenase deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00237 3-Methylcrotonyl Coa Carboxylase Deficiency Type I DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00140 3-Methylglutaconic Aciduria Type III DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00236 Propionic Acidemia DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00524 Isovaleric acidemia DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00200 Methylmalonic Aciduria DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00238 Isovaleric Aciduria DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00032 Valine, Leucine and Isoleucine Degradation DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00173 Beta-Ketothiolase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00523 Isobutyryl-coa dehydrogenase deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00384 Methylmalonate Semialdehyde Dehydrogenase Deficiency DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 SMP00199 Maple Syrup Urine Disease DB00121 Biotin DB00139 Succinic acid DB00142 L-Glutamic Acid DB00147 Pyridoxal DB00161 L-Valine DB00167 L-Isoleucine DB03229 2-Oxo-4-Methylpentanoic Acid DB04074 Alpha-ketoisovalerate P21953 P12694 P09622 P35914 P54687 P11182 P26440 P11310 P30084 Q96RQ3 Q9HCC0 P16219 P45954 Q9UKU7 Q6NVY1 P31937 P80404 Q99714 P42765 Q02252 P05165 P05166 Q96PE7 P22033 Q06278 P05091 Q13825 P54868 P24752 P55809 BE0001822 3-methyl-2-oxobutanoate hydroxymethyltransferase Neisseria meningitidis serogroup B (strain MC58) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown 3-methyl-2-oxobutanoate hydroxymethyltransferase Coenzyme transport and metabolism 5,10-methylenetetrahydrofolate + 3-methyl-2- oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate panB None 6.39 27740.0 Neisseria meningitidis serogroup B (strain MC58) GenBank Gene Database AE002098 GenBank Protein Database 7226107 UniProtKB Q9JZW6 UniProt Accession PANB_NEIMB EC 2.1.2.11 Ketopantoate hydroxymethyltransferase >3-methyl-2-oxobutanoate hydroxymethyltransferase MITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSL RDMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAE TTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMEC VLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQA AVRAYVAEVKAKTFPAAEHIFAD >792 bp ATGATTACTGTGAACACACTGCAAAAAATGAAGGCGGCGGGCGAAAAAATCGCTATGCTG ACCGCTTACGAATCCAGTTTTGCCGCGCTGATGGACGATGCCGGCGTGGAAATGCTGCTG GTCGGCGATTCTTTGGGGATGGCGGTTCAGGGGCGGAAATCGACGCTGCCCGTCAGCCTG CGCGATATGTGTTATCACACCGAATGTGTAGCACGCGGTGCAAAAAATGCGATGATTGTC AGCGATTTGCCGTTTGGTGCATATCAGCAGAGTAAGGAGCAGGCGTTTGCCGCCGCCGCC GAACTGATGGCTGCCGGCGCGCATATGGTTAAACTCGAAGGCGGCGTGTGGATGGCGGAA ACGACTGAATTTTTGCAAATGCGCGGTATTCCGGTTTGTGCGCACATCGGTCTGACCCCG CAATCCGTGTTTGCCTTCGGCGGATATAAAGTTCAGGGGCGCGGCGGCAAGGCGCAGGCG TTGCTTAACGATGCCAAGGCGCATGACGATGCGGGGGCGGCGGTCGTGCTGATGGAGTGC GTACTGGCGGAACTGGCAAAAAAGGTAACTGAAACTGTTTCCTGTCCGACCATCGGCATC GGCGCGGGTGCGGATTGCGACGGGCAGGTTTTGGTGATGCACGATATGCTCGGCATTTTC CCGGGTAAGACGGCGAAATTCGTCAAAAACTTTATGCAGGGGCATGATAGTGTTCAAGCG GCGGTTCGGGCGTATGTTGCCGAAGTCAAAGCCAAAACCTTCCCTGCTGCGGAACATATT TTTGCAGATTGA PF02548 Pantoate_transf function methyltransferase activity function glycine hydroxymethyltransferase activity function hydroxymethyl-, formyl- and related transferase activity function catalytic activity function 3-methyl-2-oxobutanoate hydroxymethyltransferase activity function transferase activity function transferase activity, transferring one-carbon groups process cofactor metabolism process coenzyme metabolism process coenzyme biosynthesis process physiological process process pantothenate biosynthesis process metabolism process cellular metabolism BE0001833 Deacetoxycephalosporin C synthase Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Deacetoxycephalosporin C synthase Involved in iron ion binding Catalyzes the step from penicillin N to deacetoxy- cephalosporin C cefE None 4.94 34556.0 Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602) GenBank Gene Database M32324 GenBank Protein Database 153205 UniProtKB P18548 UniProt Accession CEFE_STRC2 DAOCS EC 1.14.20.1 Expandase >Deacetoxycephalosporin C synthetase MDTTVPTFSLAELQQGLHQDEFRRCLRDKGLFYLTDCGLTDTELKSAKDLVIDFFEHGSE AEKRAVTSPVPTMRRGFTGLESESTAQITNTGSYSDYSMCYSMGTADNLFPSGDFERIWT QYFDRQYTASRAVAREVLRATGTEPDGGVEAFLDCEPLLRFRYFPQVPEHRSAEEQPLRM APHYDLSMVTLIQQTPCANGFVSLQAEVGGAFTDLPYRPDAVLVFCGAIATLVTGGQVKA PRHHVAAPRRDQIAGSSRTSSVFFLRPNADFTFSVPLARECGFDVSLDGETATFQDWIGG NYVNIRRTSKA >936 bp ATGGACACGACGGTGCCCACCTTCAGCCTGGCCGAACTCCAGCAGGGCCTGCACCAGGAC GAGTTCCGCAGGTGTCTGAGGGACAAGGGCCTCTTCTATCTGACGGACTGCGGTCTGACC GACACCGAGCTGAAGTCGGCCAAGGACCTCGTCATCGACTTCTTCGAGCACGGCAGCGAG GCGGAGAAGCGCGCCGTCACCTCGCCCGTCCCCACCATGCGCCGCGGCTTCACCGGGCTG GAGTCGGAGAGCACCGCCCAGATCACCAATACCGGCAGCTACTCCGACTACTCGATGTGC TACTCGATGGGCACCGCGGACAACCTCTTCCCGTCCGGTGACTTCGAGCGGATCTGGACC CAGTACTTCGACCGCCAGTACACCGCCTCCCGCGCGGTCGCCCGGGAGGTCCTGCGGGCG ACCGGGACCGAGCCCGACGGCGGGGTCGAGGCCTTCCTCGACTGCGAGCCGCTGCTGCGG TTCCGCTACTTCCCGCAGGTCCCCGAGCACCGCAGCGCCGAGGAGCAGCCCCTGCGGATG GCGCCGCACTACGACCTGTCGATGGTCACCCTCATCCAGCAGACACCCTGCGCCAACGGC TTCGTCAGCCTCCAGGCCGAGGTCGGCGGCGCGTTCACGGACCTGCCCTACCGTCCGGAC GCCGTCCTCGTCTTCTGCGGCGCCATCGCGACCCTGGTGACCGGCGGCCAGGTCAAGGCC CCCCGGCACCATGTCGCGGCCCCCCGCAGGGACCAGATAGCGGGCAGCAGCCGCACCTCC AGTGTGTTCTTCCTCCGTCCCAACGCGGACTTCACCTTCTCCGTCCCGCTGGCGCGCGAG TGCGGCTTCGATGTCAGCCTGGACGGCGAGACCGCCACGTTCCAGGATTGGATCGGGGGC AACTACGTGAACATCCGCCGCACATCCAAGGCATAG PF03171 2OG-FeII_Oxy function cation binding function transition metal ion binding function iron ion binding function binding function catalytic activity function oxidoreductase activity function ion binding process biosynthesis process physiological process process metabolism BE0001742 2-isopropylmalate synthase Mycobacterium tuberculosis # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown 2-isopropylmalate synthase Amino acid transport and metabolism Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA None 4.79 70114.0 Mycobacterium tuberculosis GenBank Gene Database U88526 GenBank Protein Database 1850985 UniProtKB P96420 UniProt Accession LEU1_MYCTU Alpha-IPM synthetase Alpha-isopropylmalate synthase EC 2.3.3.13 >2-isopropylmalate synthase MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR >1935 bp GTGACAACTTCTGAATCGCCCGACGCCTATACCGAGTCGTTTGGGGCCCACACCATCGTG AAACCCGCCGGCCCACCTCGCGTCGGTCAGCCCTCGTGGAATCCGCAGCGAGCCTCGTCG ATGCCGGTCAACCGCTACCGGCCGTTCGCCGAGGAGGTCGAGCCCATCCGGCTGAGAAAC CGCACGTGGCCTGATCGCGTCATCGATCGTGCGCCGCTGTGGTGCGCGGTCGACTTACGC GATGGCAACCAGGCGCTGATCGACCCGATGAGCCCGGCCCGCAAGCGCCGCATGTTCGAC CTGCTGGTCCGGATGGGCTACAAGGAGATTGAGGTGGGGTTCCCCTCGGCCAGCCAGACC GACTTCGACTTCGTCAGAGAGATCATCGAGCAGGGCGCCATTCCCGACGACGTCACCATC CAGGTGCTCACCCAATGCCGTCCCGAGCTGATCGAGCGCACCTTCCAGGCGTGTTCGGGC GCACCCCGGGCCATCGTGCACTTCTACAACTCGACGTCAATCCTGCAGCGCCGCGTGGTC TTTCGCGCCAACCGGGCTGAGGTGCAGGCCATCGCGACAGATGGGGCGCGCAAGTGCGTC GAGCAGGCCGCCAAATACCCGGGCACGCAGTGGCGATTCGAGTACTCCCCGGAGTCCTAC ACCGGCACCGAACTGGAATACGCCAAACAGGTGTGCGACGCCGTCGGCGAGGTCATTGCG CCGACGCCGGAGCGCCCGATCATCTTCAACCTGCCCGCCACGGTGGAGATGACGACGCCC AATGTCTACGCCGACTCGATCGAGTGGATGAGCCGCAACCTAGCCAACCGGGAGTCGGTC ATCCTGAGCCTGCACCCGCACAATGACCGCGGAACCGCCGTCGCCGCAGCGGAATTGGGT TTCGCGGCCGGGGCTGATCGGATCGAGGGCTGCCTGTTCGGCAACGGCGAGCGCACCGGC AACGTGTGCCTGGTCACGCTGGGACTCAACCTGTTCTCCCGAGGTGTGGACCCGCAGATC GACTTCTCCAATATTGACGAGATCCGGCGCACGGTGGAGTACTGCAACCAGCTGCCGGTG CACGAACGTCACCCCTATGGCGGCGACCTGGTGTACACCGCGTTCTCCGGTAGCCACCAG GACGCCATCAACAAGGGCCTAGACGCGATGAAGCTGGATGCGGATGCCGCCGACTGTGAC GTCGACGACATGCTGTGGCAGGTGCCGTATCTGCCCATCGACCCGCGCGATGTCGGGCGC ACCTACGAGGCGGTGATCCGGGTCAACTCGCAGTCCGGCAAGGGCGGCGTGGCCTACATC ATGAAGACCGACCACGGCCTTTCCCTGCCGCGGCGGCTGCAGATCGAGTTTTCCCAGGTA ATCCAGAAGATCGCAGAGGGTACAGCAGGCGAGGGTGGCGAGGTCTCGCCCAAGGAGATG TGGGATGCGTTCGCCGAGGAGTATCTGGCCCCGGTGCGGCCTTTGGAGCGGATAAGGCAA CATGTGGACGCTGCCGACGACGACGGCGGCACGACCAGCATCACGGCGACCGTCAAGATC AACGGCGTGGAGACCGAGATCAGCGGGTCCGGTAACGGTCCGTTGGCCGCGTTCGTCCAT GCGCTGGCCGATGTCGGGTTTGACGTGGCCGTGCTGGACTACTACGAGCACGCGATGAGC GCCGGCGACGACGCTCAGGCCGCCGCGTATGTGGAGGCCTCCGTGACGATCGCGAGCCCG GCGCAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGATCGCGAGCCCGGCG CAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGAGTAAGACGGTGTGGGGT GTCGGTATCGCACCGTCAATCACCACCGCGTCGCTGCGCGCCGTGGTGTCGGCGGTCAAC CGGGCGGCACGCTAG PF00682 HMGL-like PF08502 LeuA_dimer function 2-isopropylmalate synthase activity function transferase activity function transferase activity, transferring acyl groups function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer function catalytic activity process leucine metabolism process metabolism process leucine biosynthesis process cellular metabolism process amino acid metabolism process amino acid and derivative metabolism process organic acid metabolism process carboxylic acid metabolism process branched chain family amino acid metabolism process physiological process BE0000721 Branched-chain-amino-acid aminotransferase, mitochondrial Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Branched-chain-amino-acid aminotransferase, mitochondrial Amino acid transport and metabolism Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids BCAT2 19q13 Isoform A:Mitochondrion. Isoform B:Cytoplasm None 8.82 44288.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:977 GenAtlas BCAT2 GeneCards BCAT2 GenBank Gene Database U68418 GenBank Protein Database 2342862 UniProtKB O15382 UniProt Accession BCAT2_HUMAN BCAT(m) Branched-chain-amino-acid aminotransferase, mitochondrial precursor EC 2.6.1.42 Placental protein 18 PP18 >Branched-chain-amino-acid aminotransferase, mitochondrial precursor MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP TMENGPELILRFQKELKEIQYGIRAHEWMFPV >1179 bp ATGGCCGCAGCCGCTCTGGGGCAGATCTGGGCACGAAAGCTTCTCTCTGTCCCTTGGCTT CTGTGTGGTCCCAGAAGATATGCCTCCTCCAGTTTCAAGGCTGCAGACCTGCAGCTGGAA ATGACACAGAAGCCTCATAAGAAGCCTGGCCCCGGCGAGCCCCTGGTGTTTGGGAAGACA TTTACCGACCACATGCTGATGGTGGAATGGAATGACAAGGGCTGGGGCCAGCCCCGAATC CAGCCCTTCCAGAACCTCACGCTGCACCCAGCCTCCTCCAGCCTCCACTACTCCCTGCAG CTGTTTGAGGGCATGAAGGCGTTCAAAGGCAAAGACCAGCAGGTGCGCCTCTTCCGCCCC TGGCTCAACATGGACCGGATGCTGCGCTCAGCCATGCGCCTGTGCCTGCCGAGTTTCGAC AAGCTGGAGTTGCTGGAGTGCATCCGCCGGCTCATCGAAGTGGACAAGGACTGGGTCCCC GATGCCGCCGGCACCAGCCTCTATGTGCGGCCTGTGCTCATTGGGAACGAGCCCTCGCTG GGTGTCAGCCAGCCCAGGCGCGCGCTCCTGTTCGTCATTCTCTGCCCAGTGGGTGCCTAC TTCCCTGGAGGCTCCGTGACCCCGGTCTCCCTCCTGGCCGACCCAGCCTTCATCCGGGCC TGGGTGGGCGGGGTCGGCAACTACAAGTTAGGTGGGAATTATGGGCCCACCGTGTTAGTG CAACAGGAGGCACTCAAGCGGGGCTGTGAACAGGTCCTCTGGCTGTATGGGCCCGACCAC CAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGGACCCACGAAGATGGGGTG CTGGAGCTGGTGACGCCCCCGCTGAATGGTGTTATCCTGCCTGGAGTGGTCAGACAGAGT CTACTGGACATGGCTCAGACCTGGGGTGAGTTCCGGGTGGTGGAGCGCACGATCACCATG AAGCAGTTGCTGCGGGCCTTGGAGGAGGGCCGCGTGCGGGAAGTCTTTGGCTCGGGCACC GCTTGCCAGGTCTGCCCAGTGCACCGAATCCTGTACAAAGACAGGAACCTCCATATTCCC ACCATGGAAAATGGGCCTGAGCTGATCCTCCGCTTCCAGAAGGAGCTGAAGGAGATCCAG TACGGAATCAGAGCCCACGAGTGGATGTTCCCGGTGTGA PF01063 Aminotran_4 function transferase activity function transferase activity, transferring nitrogenous groups function transaminase activity function branched-chain-amino-acid transaminase activity function catalytic activity process branched chain family amino acid metabolism process physiological process process metabolism process cellular metabolism process amino acid metabolism process amino acid and derivative metabolism BE0000440 Monocarboxylate transporter 2 Human inhibitor # Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10417314 unknown Monocarboxylate transporter 2 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter SLC16A7 12q13 Cell membrane; multi-pass membrane protein 16-36 60-80 90-110 116-136 149-169 174-194 247-267 283-303 313-333 339-359 374-394 407-427 9.68 52187.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10928 GenAtlas SLC16A7 GeneCards SLC16A7 GenBank Gene Database AF058056 GenBank Protein Database 3047402 UniProtKB O60669 UniProt Accession MOT2_HUMAN MCT 2 Solute carrier family 16 member 7 >Monocarboxylate transporter 2 MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAW ISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFIT GLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLI LGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFS LFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSV GLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFE TLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW LLIGNAINYRLLAKERKEENARQKSRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI >1437 bp ATGCCACCAATGCCAAGTGCCCCACCTGTGCATCCACCTCCAGATGGAGGATGGGGTTGG ATTGTGGTTGGAGCAGCTTTTATCTCCATTGGATTTTCCTATGCATTCCCCAAAGCTGTC ACCGTATTCTTCAAAGAAATTCAGCAAATATTCCACACTACCTACAGTGAAATAGCATGG ATTTCATCCATTATGCTGGCTGTTATGTACGCAGGAGGTCCTGTAAGTAGTGTTTTGGTG AATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATG GTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACA GGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTAT AGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCA TTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATT TTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCC AATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCA AAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCC CTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGT TTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTAC TCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTA GGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCA ATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTG GTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAA ACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATT GTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACT GGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGG CTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAAT GCAAGGCAGAAGTCCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTT AACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAA PF07690 MFS_1 component cell component intrinsic to membrane component integral to membrane component membrane function transporter activity function monocarboxylate porter activity function organic acid transporter activity function carboxylic acid transporter activity function monocarboxylic acid transporter activity process transport process organic anion transport process ion transport process anion transport process physiological process process cellular physiological process BE0000669 Monocarboxylate transporter 1 Human inhibitor # Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW: Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J. 1998 Jul 1;333 ( Pt 1):167-74. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9639576 unknown Monocarboxylate transporter 1 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate SLC16A1 1p12 Cell membrane; multi-pass membrane protein 16-36 60-80 87-107 112-132 144-164 167-187 263-283 299-319 329-349 354-374 390-410 423-443 8.82 53959.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10922 GenAtlas SLC16A1 GeneCards SLC16A1 GenBank Gene Database L31801 GenBank Protein Database 561722 UniProtKB P53985 UniProt Accession MOT1_HUMAN MCT 1 Solute carrier family 16 member 1 >Monocarboxylate transporter 1 MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA AESPDQKDTEGGPKEEESPV >1503 bp ATGCCACCAGCAGTTGGAGGTCCAGTTGGATACACCCCCCCAGATGGAGGCTGGGGCTGG GCAGTGGTAATTGGAGCTTTCATTTCCATCGGCTTCTCTTATGCATTTCCCAAATCAATT ACTGTCTTCTTCAAAGAGATTGAAGGTATATTCCATGCCACCACCAGCGAAGTGTCATGG ATATCCTCCATAATGTTGGCTGTCATGTATGGTGGAGGTCCTATCAGCAGTATCCTGGTG AATAAATATGGAAGTCGTATAGTCATGATTGTTGGTGGCTGCTTGTCAGGCTGTGGCTTG ATTGCAGCTTCTTTCTGTAACACCGTACAGCAACTATACGTCTGTATTGGAGTCATTGGA GGTCTTGGGCTTGCCTTCAACTTGAATCCAGCTCTGACCATGATTGGCAAGTATTTCTAC AAGAGGCGACCATTGGCCAACGGACTGGCCATGGCAGGCAGCCCTGTGTTCCTCTGTACT CTGGCCCCCCTCAATCAGGTTTTCTTCGGTATCTTTGGATGGAGAGGAAGCTTTCTAATT CTTGGGGGCTTGCTACTAAACTGCTGTGTTGCTGGAGCCCTCATGCGACCAATCGGGCCC AAGCCAACCAAGGCAGGGAAAGATAAGTCTAAAGCATCCCTTGAGAAAGCTGGAAAATCT GGTGTGAAAAAAGATCTGCATGATGCAAATACAGATCTTATTGGAAGACACCCTAAACAA GAGAAACGATCAGTCTTCCAAACAATTAATCAGTTCCTGGACTTAACCCTATTCACCCAC AGAGGCTTTTTGCTATACCTCTCTGGAAATGTGATCATGTTTTTTGGACTCTTTGCACCT TTGGTGTTTCTTAGTAGTTATGGGAAGAGTCAGCATTATTCTAGTGAGAAGTCTGCCTTC CTTCTTTCCATTCTGGCTTTTGTTGACATGGTAGCCCGACCATCTATGGGACTTGTAGCC AACACAAAGCCAATAAGACCTCGAATTCAGTATTTCTTTGCGGCTTCCGTTGTTGCAAAT GGAGTGTGTCATATGCTAGCACCTTTATCCACTACCTATGTTGGATTCTGTGTCTATGCG GGATTCTTTGGATTTGCCTTCGGGTGGCTCAGCTCCGTATTGTTTGAAACATTGATGGAC CTTGTTGGACCCCAGAGGTTCTCCAGCGCTGTGGGATTGGTGACCATTGTGGAATGCTGT CCTGTCCTCCTGGGGCCACCACTTTTAGGTCGGCTCAATGACATGTATGGAGACTACAAA TACACATACTGGGCATGTGGCGTCGTCCTAATTATTTCAGGTATCTATCTCTTCATTGGC ATGGGCATCAATTATCGACTTTTGGCAAAAGAACAGAAAGCAAACGAGCAGAAAAAGGAA AGTAAAGAGGAAGAGACCAGTATAGATGTTGCTGGGAAGCCAAATGAAGTTACCAAAACA GCAGAATCTCCGGACCAGAAAGACACAGAAGGAGGGCCCAAGGAGGAGGAAAGTCCAGTC TGA PF07690 MFS_1 component intrinsic to membrane component integral to membrane component membrane component cell function organic acid transporter activity function carboxylic acid transporter activity function monocarboxylic acid transporter activity function transporter activity function monocarboxylate porter activity process ion transport process anion transport process physiological process process cellular physiological process process transport process organic anion transport BE0000449 Monocarboxylate transporter 4 Human substrate # Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11101640 unknown Monocarboxylate transporter 4 Carbohydrate transport and metabolism Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate SLC16A3 17q25 Cell membrane; multi-pass membrane protein 18-38 62-82 85-105 110-130 150-170 180-200 228-248 265-285 295-315 318-338 352-372 385-405 8.03 49470.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:10924 GenAtlas SLC16A3 GeneCards SLC16A3 GenBank Gene Database U81800 GenBank Protein Database 2463634 UniProtKB O15427 UniProt Accession MOT4_HUMAN MCT 3 MCT 4 Solute carrier family 16 member 3 >Monocarboxylate transporter 4 MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV >1398 bp ATGGGAGGGGCCGTGGTGGACGAGGGCCCCACAGGCGTCAAGGCCCCTGACGGCGGCTGG GGCTGGGCCGTGCTCTTCGGCTGTTTCGTCATCACTGGCTTCTCCTACGCCTTCCCCAAG GCCGTCAGTGTCTTCTTCAAGGAGCTCATACAGGAGTTTGGGATCGGCTACAGCGACACA GCCTGGATCTCCTCCATCCTGCTGGCCATGCTCTACGGGACAGGTCCGCTCTGCAGTGTG TGCGTGAACCGCTTTGGCTGCCGGCCCGTCATGCTTGTGGGGGGTCTCTTTGCGTCGCTG GGCATGGTGGCTGCGTCCTTTTGCCGGAGCATCATCCAGGTCTACCTCACCACTGGGGTC ATCACGGGGTTGGGTTTGGCACTCAACTTCCAGCCCTCGCTCATCATGCTGAACCGCTAC TTCAGCAAGCGGCGCCCCATGGCCAACGGGCTGGCGGCAGCAGGTAGCCCTGTCTTCCTG TGTGCCCTGAGCCCGCTGGGGCAGCTGCTGCAGGACCGCTACGGCTGGCGGGGCGGCTTC CTCATCCTGGGCGGCCTGCTGCTCAACTGCTGCGTGTGTGCCGCACTCATGAGGCCCCTG GTGGTCACGGCCCAGCCGGGCTCGGGGCCGCCGCGACCCTCCCGGCGCCTGCTAGACCTG AGCGTCTTCCGGGACCGCGGCTTTGTGCTTTACGCCGTGGCCGCCTCGGTCATGGTGCTG GGGCTCTTCGTCCCGCCCGTGTTCGTGGTGAGCTACGCCAAGGACCTGGGCGTGCCCGAC ACCAAGGCCGCCTTCCTGCTCACCATCCTGGGCTTCATTGACATCTTCGCGCGGCCGGCC GCGGGCTTCGTGGCGGGGCTTGGGAAGGTGCGGCCCTACTCCGTCTACCTCTTCAGCTTC TCCATGTTCTTCAACGGCCTCGCGGACCTGGCGGGCTCTACGGCGGGCGACTACGGCGGC CTCGTGGTCTTCTGCATCTTCTTTGGCATCTCCTACGGCATGGTGGGGGCCCTGCAGTTC GAGGTGCTCATGGCCATCGTGGGCACCCACAAGTTCTCCAGTGCCATTGGCCTGGTGCTG CTGATGGAGGCGGTGGCCGTGCTCGTCGGGCCCCCTTCGGGAGGCAAACTCCTGGATGCG ACCCACGTCTACATGTACGTGTTCATCCTGGCGGGGGCCGAGGTGCTCACCTCCTCCCTG ATTTTGCTGCTGGGCAACTTCTTCTGCATTAGGAAGAAGCCCAAAGAGCCACAGCCTGAG GTGGCGGCCGCGGAGGAGGAGAAGCTCCACAAGCCTCCTGCAGACTCGGGGGTGGACTTG CGGGAGGTGGAGCATTTCCTGAAGGCTGAGCCTGAGAAAAACGGGGAGGTGGTTCACACC CCGGAAACAAGTGTCTGA PF07690 MFS_1 component cell component intrinsic to membrane component integral to membrane component membrane function monocarboxylic acid transporter activity function transporter activity function monocarboxylate porter activity function organic acid transporter activity function carboxylic acid transporter activity process transport process organic anion transport process ion transport process anion transport process physiological process process cellular physiological process "

owl:sameAs

drug:L-Glutamic Acid

Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB04074"

Context graph