Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03997"

PredicateValue (sorted: default)
rdfs:label
"Phosphoric Acid Mono-[2-Amino-3-(3h-Imidazol-4-Yl)-Propyl]Ester"
rdf:type
drugbank:drugs
drugbank:description
" experimental logP -1.7 ALOGPS logS -0.89 ALOGPS Water Solubility 2.85e+01 g/l ALOGPS logP -2.6 ChemAxon IUPAC Name [(2R)-2-amino-3-(imidazol-4-yl)propoxy]phosphonic acid ChemAxon Traditional IUPAC Name (2R)-2-amino-3-(imidazol-4-yl)propoxyphosphonic acid ChemAxon Molecular Weight 220.143 ChemAxon Monoisotopic Weight 220.048717367 ChemAxon SMILES N[C@@H](COP(O)(O)=O)Cc1cncn1 ChemAxon Molecular Formula C6H11N3O4P ChemAxon Polar Surface Area (PSA) 118.56 ChemAxon Refractivity 47.87 ChemAxon Polarizability 18.97 ChemAxon Rotatable Bond Count 5 ChemAxon H Bond Acceptor Count 6 ChemAxon H Bond Donor Count 3 ChemAxon pKa (strongest acidic) 1.54 ChemAxon pKa (strongest basic) 9.59 ChemAxon Physiological Charge -1 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon ChEBI 16996 PubChem Compound 6326760 PubChem Substance 46508216 PDB HSA BE0001396 Histidinol-phosphate aminotransferase Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Histidinol-phosphate aminotransferase Amino acid transport and metabolism L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate hisC None 4.72 39361.0 Escherichia coli (strain K12) GenBank Gene Database X03416 GenBank Protein Database 41695 UniProtKB P06986 UniProt Accession HIS8_ECOLI EC 2.6.1.9 HPAT HspAT Imidazole acetol- phosphate transaminase >Histidinol-phosphate aminotransferase MSTVTITDLARENVRNLTPYQSARRLGGNGDVWLNANEYPTAVEFQLTQQTLNRYPECQP KAVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETI GVECRTVPTLDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRGKAI VVADEAYIEFCPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINLLMKVI APYPLSTPVADIAAQALSPQGIVAMRERVAQIIAEREYLIAALKEIPCVEQVFDSETNYI LARFKASSAVFKSLWDQGIILRDQNKQPSLSGCLRITVGTREESQRVIDALRAEQV >1071 bp ATGAGCACCGTGACTATTACCGATTTAGCGCGTGAAAACGTCCGCAACCTGACGCCGTAT CAGTCGGCGCGTCGTCTGGGCGGTAACGGCGATGTCTGGCTGAACGCCAACGAATACCCC ACTGCCGTGGAGTTTCAGCTTACTCAGCAAACGCTCAACCGCTACCCGGAATGCCAGCCG AAAGCGGTGATTGAAAATTACGCGCAATATGCAGGCGTAAAACCGGAGCAGGTGCTGGTC AGCCGTGGCGCGGACGAAGGTATTGAACTGCTGATTCGCGCTTTTTGCGAACCGGGTAAA GACGCCATCCTCTACTGCCCGCCAACGTACGGCATGTACAGCGTCAGCGCCGAAACGATT GGCGTCGAGTGTCGCACAGTGCCGACGCCGGACAACTGGCAACTGGACTTACAGGGCATT TCCGACAAGCTGGACGGCGTAAAAGCGGTTTATGTTTGCAGCCCCAATAACCCGACCGGG CAACTGATCAATCCGCAGGATTTTCGCACCCTGCTGGAGTTAACCCGCGGTAAGGCGATT GTGGTTGCCGATGAAGCCTATATCGAGTTTTGCCCGCAGGCATCGCTGGCTGGCTGGCTG GCGGAATATCCGCACCTGGCTATTTTACGCACACTGTCGAAAGCTTTTGCTCTGGCGGGG CTTCGTTGCGGATTTACGCTGGCAAACGAAGAAGTCATCAACCTGCTGATGAAAGTGATC GCCCCCTACCCGCTCTCGACGCCGGTTGCCGACATTGCGGCCCAGGCGTTAAGCCCACAG GGAATCGTCGCCATGCGCGAACGGGTAGCGCAAATTATTGCAGAACGCGAATACCTGATT GCCGCACTGAAAGAGATCCCCTGCGTAGAGCAGGTTTTCGACTCTGAAACCAACTACATT CTGGCGCGCTTTAAAGCCTCCAGTGCGGTGTTTAAATCTTTGTGGGATCAGGGCATTATC TTACGTGATCAGAATAAACAACCCTCTTTAAGCGGCTGCCTGCGAATTACCGTCGGAACC CGTGAAGAAAGCCAGCGCGTCATTGACGCCTTACGTGCGGAGCAAGTTTGA PF00155 Aminotran_1_2 function transferase activity function transferase activity, transferring nitrogenous groups function transaminase activity function catalytic activity function histidinol-phosphate transaminase activity process biosynthesis process histidine family amino acid metabolism process histidine metabolism process physiological process process histidine biosynthesis process metabolism process cellular metabolism process amino acid metabolism process amino acid and derivative metabolism BE0001481 Histidinol-phosphate aminotransferase Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Histidinol-phosphate aminotransferase Amino acid transport and metabolism L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate hisC None 5.15 39298.0 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GenBank Gene Database AE000512 GenBank Protein Database 4981580 UniProtKB Q9X0D0 UniProt Accession HIS8_THEMA EC 2.6.1.9 Imidazole acetol- phosphate transaminase >Histidinol-phosphate aminotransferase MNPLDLIAKRAYPYETEKRDKTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYDSPDEE LIEKILSYLDTDFLSKNNVSVGNGADEIIYVMMLMFDRSVFFPPTYSCYRIFAKAVGAKF LEVPLTKDLRIPEVNVGEGDVVFIPNPNNPTGHVFEREEIERILKTGAFVALDEAYYEFH GESYVDFLKKYENLAVIRTFSKAFSLAAQRVGYVVASEKFIDAYNRVRLPFNVSYVSQMF AKVALDHREIFEERTKFIVEERERMKSALREMGYRITDSRGNFVFVFMEKEEKERLLEHL RTKNVAVRSFREGVRITIGKREENDMILRELEVFK >1008 bp TCATTTGAACACCTCCAGTTCTCTCAGAATCATATCGTTCTCTTCGCGTTTTCCGATAGT GATTCTAACACCTTCCCTGAAACTGCGAACAGCGACGTTCTTCGTCCGGAGGTGTTCGAG AAGTCTTTCTTTTTCTTCCTTCTCCATGAATACGAACACGAAGTTTCCTCTGGAGTCGGT GATTCGGTATCCCATTTCCCTGAGAGCACTCTTCATCCTCTCGCGTTCTTCCACGATGAA CTTCGTTCTTTCTTCAAAGATCTCTCTGTGATCGAGAGCTACCTTTGCGAACATCTGGGA GACGTAGCTCACGTTGAAAGGAAGTCTCACCCTGTTGTAAGCGTCAATGAACTTCTCCGA GGCCACAACGTATCCGACACGTTGCGCTGCCAGGGAAAACGCTTTCGAGAAAGTCCTGAT CACAGCGAGATTTTCGTATTTCTTCAGAAAATCCACATAACTTTCTCCGTGGAATTCGTA GTAGGCTTCGTCCAGCGCGACGAAGGCACCCGTTTTCAGGATTCTTTCTATTTCCTCTCT TTCGAAGACATGGCCCGTTGGATTGTTCGGGTTCGGAATGAAAACAACGTCTCCTTCTCC CACGTTCACCTCAGGTATCCTCAGATCTTTCGTGAGCGGCACTTCCAGGAATTTCGCTCC AACTGCCTTCGCAAAGATCCTGTAGCAGCTGTAGGTCGGGGGAAAGAAAACGGAACGGTC GAACATGAGCATCATCACGTAGATGATCTCATCCGCTCCGTTTCCCACAGAGACGTTGTT TTTCGAAAGAAAATCGGTGTCGAGGTATGAGAGTATCTTTTCTATTAATTCTTCATCGGG GGAGTCGTAGTAGATCCTCAGGGCGTCGCTGTTCAATCGTCGAAACACTTCATCCACGAG GTCCTCTGGAAAGGGAAACGGATTTTCATTCAGCGCAAGGTAGGTTTTGTCTCTCTTTTC GGTTTCGTACGGATACGCCCTCTTTGCAATCAAATCGAGAGGATTCAC PF00155 Aminotran_1_2 function histidinol-phosphate transaminase activity function transferase activity function transferase activity, transferring nitrogenous groups function transaminase activity function catalytic activity process histidine biosynthesis process metabolism process cellular metabolism process amino acid metabolism process amino acid and derivative metabolism process biosynthesis process histidine family amino acid metabolism process histidine metabolism process physiological process "
owl:sameAs
drug:EXPT01781

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

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