Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03792"
| Predicate | Value (sorted: none) |
|---|---|
| rdf:type | |
| rdfs:label |
"5-Amino-1h-Pyrimidine-2,4-Dione"
|
| drugbank:description |
"
experimental
This compound belongs to the pyrimidones. These are compounds whose pyrimidine ring bears a ketone.
Pyrimidones
Organic Compounds
Heterocyclic Compounds
Diazines
Pyrimidines and Pyrimidine Derivatives
Primary Aromatic Amines
Hydropyrimidines
Polyamines
hydropyrimidine
primary aromatic amine
polyamine
primary amine
amine
organonitrogen compound
logP
-1.6
ALOGPS
logS
-1.1
ALOGPS
Water Solubility
1.13e+01 g/l
ALOGPS
logP
-1.7
ChemAxon
IUPAC Name
5-amino-1,2,3,4-tetrahydropyrimidine-2,4-dione
ChemAxon
Traditional IUPAC Name
5-amino-1,3-dihydropyrimidine-2,4-dione
ChemAxon
Molecular Weight
127.1014
ChemAxon
Monoisotopic Weight
127.038176419
ChemAxon
SMILES
NC1=CNC(=O)NC1=O
ChemAxon
Molecular Formula
C4H5N3O2
ChemAxon
InChI
InChI=1S/C4H5N3O2/c5-2-1-6-4(9)7-3(2)8/h1H,5H2,(H2,6,7,8,9)
ChemAxon
InChIKey
InChIKey=BISHACNKZIBDFM-UHFFFAOYSA-N
ChemAxon
Polar Surface Area (PSA)
84.22
ChemAxon
Refractivity
29.59
ChemAxon
Polarizability
10.74
ChemAxon
Rotatable Bond Count
0
ChemAxon
H Bond Acceptor Count
3
ChemAxon
H Bond Donor Count
3
ChemAxon
pKa (strongest acidic)
9.54
ChemAxon
pKa (strongest basic)
-1.4
ChemAxon
Physiological Charge
0
ChemAxon
Number of Rings
1
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
PubChem Compound
13611
PubChem Substance
46507741
PDB
WBU
BE0003317
Ribonuclease pancreatic
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Ribonuclease pancreatic
Involved in nucleic acid binding
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA
RNASE1
14q11.2
Secreted protein
None
8.94
17644.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10044
GenAtlas
RNASE1
GenBank Gene Database
D26129
UniProtKB
P07998
UniProt Accession
RNAS1_HUMAN
EC 3.1.27.5
HP-RNase
RIB-1
Ribonuclease pancreatic precursor
RNase 1
RNase A
RNase UpI-1
>Ribonuclease pancreatic
MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSSSTYCNQMMRR
RNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTNGSRY
PNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST
>471 bp
ATGGCTCTGGAGAAGTCTCTTGTCCGGCTCCTTCTGCTTGTCCTGATACTGCTGGTGCTG
GGCTGGGTCCAGCCTTCCCTGGGCAAGGAATCCCGGGCCAAGAAATTCCAGCGGCAGCAT
ATGGACTCAGACAGTTCCCCCAGCAGCAGCTCCACCTACTGTAACCAAATGATGAGGCGC
CGGAATATGACACAGGGGCGGTGCAAACCAGTGAACACCTTTGTGCACGAGCCCCTGGTA
GATGTCCAGAATGTCTGTTTCCAGGAAAAGGTCACCTGCAAGAACGGGCAGGGCAACTGC
TACAAGAGCAACTCCAGCATGCACATCACAGACTGCCGCCTGACAAACGGCTCCAGGTAC
CCCAACTGTGCATACCGGACCAGCCCGAAGGAGAGACACATCATTGTGGCCTGTGAAGGG
AGCCCATATGTGCCAGTCCACTTTGATGCTTCTGTGGAGGACTCTACCTAA
PF00074
RnaseA
function
hydrolase activity
function
nucleic acid binding
function
hydrolase activity, acting on ester bonds
function
nuclease activity
function
endonuclease activity
function
endoribonuclease activity
function
endoribonuclease activity, producing 3'-phosphomonoesters
function
pancreatic ribonuclease activity
function
binding
function
catalytic activity
"
|
| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object