Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03582"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"N~2~-Succinylornithine"
|
| rdf:type | |
| drugbank:description |
"
experimental
This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at his terminal nitrogen atom.
N-acyl-alpha Amino Acids
Organic Compounds
Organic Acids and Derivatives
Carboxylic Acids and Derivatives
Amino Acids, Peptides, and Analogues
Amino Fatty Acids
Dicarboxylic Acids and Derivatives
Secondary Carboxylic Acid Amides
Polyols
Polyamines
Enolates
Carboxylic Acids
Monoalkylamines
dicarboxylic acid derivative
polyol
secondary carboxylic acid amide
carboxamide group
carboxylic acid
enolate
polyamine
primary aliphatic amine
primary amine
amine
organonitrogen compound
logP
-3.4
ALOGPS
logS
-1.1
ALOGPS
Water Solubility
1.93e+01 g/l
ALOGPS
logP
-4.1
ChemAxon
IUPAC Name
(2R)-5-amino-2-(3-carboxypropanamido)pentanoic acid
ChemAxon
Traditional IUPAC Name
N~2~-succinylornithine
ChemAxon
Molecular Weight
232.2337
ChemAxon
Monoisotopic Weight
232.105921632
ChemAxon
SMILES
NCCC[C@@H](NC(=O)CCC(O)=O)C(O)=O
ChemAxon
Molecular Formula
C9H16N2O5
ChemAxon
InChI
InChI=1S/C9H16N2O5/c10-5-1-2-6(9(15)16)11-7(12)3-4-8(13)14/h6H,1-5,10H2,(H,11,12)(H,13,14)(H,15,16)/t6-/m1/s1
ChemAxon
InChIKey
InChIKey=VWXQFHJBQHTHMK-ZCFIWIBFSA-N
ChemAxon
Polar Surface Area (PSA)
129.72
ChemAxon
Refractivity
53.55
ChemAxon
Polarizability
22.77
ChemAxon
Rotatable Bond Count
8
ChemAxon
H Bond Acceptor Count
6
ChemAxon
H Bond Donor Count
4
ChemAxon
pKa (strongest acidic)
3.32
ChemAxon
pKa (strongest basic)
9.9
ChemAxon
Physiological Charge
-1
ChemAxon
Number of Rings
0
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
PubChem Compound
17754185
PubChem Substance
46507657
PDB
SUO
BE0001871
N-succinylarginine dihydrolase
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
N-succinylarginine dihydrolase
Amino acid transport and metabolism
Catalyzes the hydrolysis of 2-N-succinylarginine into 2- N-succinylornithine, ammonia and CO(2)
astB
Cytoplasmic
None
6.06
49299.0
Escherichia coli (strain K12)
GenBank Gene Database
U00096
GenBank Protein Database
1788040
UniProtKB
P76216
UniProt Accession
ASTB_ECOLI
EC 3.5.3.23
>N-succinylarginine dihydrolase
MNAWEVNFDGLVGLTHHYAGLSFGNEASTRHRFQVSNPRLAAKQGLLKMKALADAGFPQA
VIPPHERPFIPVLRQLGFSGSDEQVLEKVARQAPHWLSSVSSASPMWVANAATIAPSADT
LDGKVHLTVANLNNKFHRSLEAPVTESLLKAIFNDEEKFSVHSALPQVALLGDEGAANHN
RLGGHYGEPGMQLFVYGREEGNDTRPSRYPARQTREASEAVARLNQVNPQQVIFAQQNPD
VIDQGVFHNDVIAVSNRQVLFCHQQAFARQSQLLANLRARVNGFMAIEVPATQVSVSDTV
STYLFNSQLLSRDDGSMMLVLPQECREHAGVWGYLNELLAADNPISELKVFDLRESMANG
GGPACLRLRVVLTEEERRAVNPAVMMNDTLFNALNDWVDRYYRDRLTAADLADPQLLREG
REALDVLSQLLNLGSVYPFQREGGGNG
>1344 bp
TTATCCATTGCCCCCTCCCTCGCGCTGGAACGGATAAACCGAACCGAGATTCAGTAATTG
GCTCAATACATCCAGTGCTTCCCGCCCTTCGCGCAGCAATTGCGGGTCGGCCAGATCGGC
AGCAGTAAGGCGATCGCGGTAGTAACGATCCACCCAGTCATTGAGCGCATTAAACAGCGT
ATCGTTCATCATCACCGCCGGATTCACCGCCCGGCGTTCTTCTTCTGTCAATACCACCCG
CAACCGCAGGCACGCCGGGCCGCCGCCATTCGCCATGCTTTCACGTAAATCAAAGACTTT
TAGTTCGCTAATCGGGTTGTCAGCGGCAAGGAGTTCATTGAGATAACCCCATACTCCGGC
GTGTTCCCGACACTCCTGAGGCAGCACCAACATCATGGAACCATCATCGCGGCTCAGCAG
TTGGCTGTTAAACAGATAGGTAGACACCGTATCAGACACGGAAACCTGAGTTGCCGGAAC
TTCTATCGCCATAAAACCATTGACCCGCGCACGCAGGTTTGCCAGTAACTGTGACTGGCG
AGCGAACGCCTGTTGGTGGCAAAACAGCACCTGGCGGTTACTCACGGCAATCACGTCATT
ATGAAAAACGCCCTGGTCGATAACGTCCGGGTTTTGCTGGGCGAAAATCACCTGTTGGGG
ATTCACCTGATTCAGCCTTGCCACCGCCTCGCTGGCTTCGCGAGTCTGTCGCGCCGGATA
ACGGGAAGGCCGGGTATCATTGCCTTCTTCTCGCCCGTAGACAAAAAGTTGCATACCCGG
TTCACCGTAATGACCGCCGAGACGATTGTGGTTTGCCGCCCCCTCATCACCGAGCAACGC
TACCTGTGGCAACGCCGAATGGACGCTAAATTTCTCTTCGTCGTTAAAAATCGCTTTTAA
CAGCGATTCAGTGACGGGCGCTTCCAGCGAACGGTGAAATTTATTGTTCAGGTTGGCAAC
GGTGAGATGCACTTTGCCATCCAGCGTATCGGCAGATGGCGCGATCGTTGCCGCATTGGC
TACCCACATTGGCGAAGCGGAACTGACGCTGGAAAGCCAGTGCGGTGCCTGGCGTGCAAC
TTTTTCCAGTACCTGCTCATCGCTACCACTGAATCCCAACTGACGCAGCACCGGAATAAA
CGGACGCTCGTGCGGCGGGATCACGGCCTGGGGGAATCCCGCATCGGCAAGGGCTTTCAT
TTTCAGTAAGCCCTGCTTCGCCGCCAGTCGCGGGTTAGACACCTGAAAACGGTGACGGGT
AGAGGCTTCATTACCAAACGACAGGCCCGCGTAATGATGCGTCAGCCCTACCAGCCCGTC
GAAATTGACTTCCCAGGCGTTCAT
PF04996
AstB
function
hydrolase activity
function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
function
succinylarginine dihydrolase activity
function
catalytic activity
process
metabolism
process
urea cycle intermediate metabolism
process
arginine metabolism
process
physiological process
"
|
| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object