Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03397"

PredicateValue (sorted: default)
rdfs:label
"Uridine-Diphosphate-N-Acetylglucosamine"
rdf:type
drugbank:description
" experimental This compound belongs to the pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group. Pyrimidine Nucleotide Sugars Organic Compounds Organooxygen Compounds Carbohydrates and Carbohydrate Conjugates Glycosyl Compounds Pyrimidine Ribonucleoside Diphosphates Mixed Pentose/Hexose Disaccharides N-acyl-alpha-hexosamines Disaccharide Phosphates Organic Pyrophosphates Pyrimidones Organic Phosphoric Acids Hydropyrimidines Oxanes Organophosphate Esters Tetrahydrofurans Oxolanes Secondary Carboxylic Acid Amides Secondary Alcohols 1,2-Diols Primary Alcohols Enolates Polyamines Carboxylic Acids Ethers mixed pentose/hexose disaccharide n-acyl-alpha-hexosamine disaccharide phosphate glucosamine disaccharide amino sugar organic pyrophosphate pyrimidone organic phosphate phosphoric acid ester oxane hydropyrimidine pyrimidine tetrahydrofuran oxolane 1,2-diol secondary alcohol secondary carboxylic acid amide carboxamide group primary alcohol carboxylic acid carboxylic acid derivative ether polyamine enolate alcohol amine organonitrogen compound logP -1.4 ALOGPS logS -1.7 ALOGPS Water Solubility 1.14e+01 g/l ALOGPS logP -5.3 ChemAxon IUPAC Name [({[(2S,3R,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2S,3S,4S,5R,6S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid ChemAxon Traditional IUPAC Name {[(2S,3R,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy[(2S,3S,4S,5R,6S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphinic acid ChemAxon Molecular Weight 607.3537 ChemAxon Monoisotopic Weight 607.081569477 ChemAxon SMILES CC(=O)N[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[P@](O)(=O)O[P@](O)(=O)OC[C@@H]1O[C@H]([C@H](O)[C@H]1O)N1C=CC(=O)NC1=O ChemAxon Molecular Formula C17H27N3O17P2 ChemAxon InChI InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11-,12-,13-,14+,15+,16-/m0/s1 ChemAxon InChIKey InChIKey=LFTYTUAZOPRMMI-LSIJYXAZSA-N ChemAxon Polar Surface Area (PSA) 300.41 ChemAxon Refractivity 117.56 ChemAxon Polarizability 49.62 ChemAxon Rotatable Bond Count 10 ChemAxon H Bond Acceptor Count 14 ChemAxon H Bond Donor Count 9 ChemAxon pKa (strongest acidic) 1.74 ChemAxon pKa (strongest basic) -3.5 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 3 ChemAxon Bioavailability 0 ChemAxon MDDR-Like Rule true ChemAxon PubChem Compound 46936661 PubChem Substance 46506870 PDB UD1 BE0002025 Bifunctional protein GlmU Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Bifunctional protein GlmU Cell wall/membrane/envelope biogenesis Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc glmU Cytoplasm None 6.52 49191.0 Escherichia coli (strain K12) GenBank Gene Database X01631 UniProtKB P0ACC7 UniProt Accession GLMU_ECOLI EC 2.3.1.157] EC 2.7.7.23 Glucosamine-1-phosphate N-acetyltransferase N-acetylglucosamine-1-phosphate uridyltransferase >Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGD LLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDA KPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADM KRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQ SEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKN SVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSK AGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGAT IAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK PF00132 Hexapep PF01128 IspD function transferase activity function transferase activity, transferring phosphorus-containing groups function 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity function UDP-N-acetylglucosamine diphosphorylase activity function nucleotidyltransferase activity function catalytic activity process metabolism process carbohydrate biosynthesis process macromolecule metabolism process polysaccharide biosynthesis process lipopolysaccharide biosynthesis process macromolecule biosynthesis process primary metabolism process lipid metabolism process cellular lipid metabolism process physiological process process isoprenoid metabolism process isoprenoid biosynthesis BE0001429 UDP-N-acetylhexosamine pyrophosphorylase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-N-acetylhexosamine pyrophosphorylase Involved in nucleotidyltransferase activity Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P UAP1 1q23.3 Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the None 6.29 58770.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:12457 GenAtlas UAP1 GeneCards UAP1 GenBank Gene Database S73498 GenBank Protein Database 7717462 UniProtKB Q16222 UniProt Accession UAP1_HUMAN AGX AGX-1 Antigen X EC 2.7.7.- EC 2.7.7.23 Sperm- associated antigen 2 UDP-N-acetylglucosamine pyrophosphorylase >UDP-N-acetylhexosamine pyrophosphorylase MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSS HQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAY PKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTK HKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDME QRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPY VDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTT ARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQ CEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI >1518 bp ATGAACATTAATGACCTCAAACTCACGTTGTCCAAAGCTGGGCAAGAGCACCTACTACGT TTCTGGAATGAGCTTGAAGAAGCCCAACAGGTAGAACTTTATGCAGAGCTCCAGGCCATG AACTTTGAGGAGCTGAACTTCTTTTTCCAAAAGGCCATTGAAGGTTTTAACCAGTCTTCT CACCAAAAGAATGTGGATGCACGAATGGAACCTGTGCCTCGAGAGGTATTAGGCAGTGCT ACAAGGGATCAAGATCAGCTCCAGGCCTGGGAAAGTGAAGGACTTTTCCAGATTTCTCAG AATAAAGTAGCAGTTCTTCTTCTAGCTGGTGGGCAGGGGACAAGACTCGGCGTTGCATAT CCTAAGGGGATGTATGATGTTGGTTTGCCATCCCGTAAGACACTTTTTCAGATTCAAGCA GAGCGTATCCTGAAGCTACAGCAGGTTGCTGAAAAATATTATGGCAACAAATGCATTATT CCATGGTATATAATGACCAGTGGCAGAACAATGGAATCTACAAAGGAGTTCTTCACCAAG CACAAGTACTTTGGTTTAAAAAAAGAGAATGTAATCTTTTTTCAGCAAGGAATGCTCCCC GCCATGAGTTTTGATGGGAAAATTATTTTGGAAGAGAAGAACAAAGTTTCTATGGCTCCA GATGGGAATGGTGGTCTTTATCGGGCACTTGCAGCCCAGAATATTGTGGAGGATATGGAG CAAAGAGGCATTTGGAGCATTCATGTCTATTGTGTTGACAACATATTAGTAAAAGTGGCA GACCCACGGTTCATTGGATTTTGCATTCAGAAAGGAGCAGACTGTGGAGCAAAGGTGGTA GAGAAAACGAACCCTACAGAACCAGTTGGAGTGGTTTGCCGAGTGGATGGAGTTTACCAG GTGGTAGAATATAGTGAGATTTCCCTGGCAACAGCTCAAAAACGAAGCTCAGACGGACGA CTGCTGTTCAATGCGGGGAACATTGCCAACCATTTCTTCACTGTACCATTTCTGAGAGAT GTTGTCAATGTTTATGAACCTCAGTTGCAGCACCATGTGGCTCAAAAGAAGATTCCTTAT GTGGATACCCAAGGACAGTTAATTAAGCCAGACAAACCCAATGGAATAAAGATGGAAAAA TTTGTCTTTGACATCTTCCAGTTTGCAAAGAAGTTTGTGGTATATGAAGTATTGCGAGAA GATGAGTTTTCCCCACTAAAGAATGCTGATAGTCAGAATGGGAAAGACAACCCTACTACT GCAAGGCATGCTTTGATGTCCCTTCATCATTGCTGGGTCCTCAATGCAGGGGGCCATTTC ATAGATGAAAATAGCTCTCGCCTTCCAGCAATTCCCCGCTTGAAGGATGCCAATGATGTA CCAATCCAATGTGAAATCTCTCCTCTTATCTCCTATGCTGGAGAAGGATTAGAAAGTTAT GTGGCAGATAAAGAATTCCATGCACCTCTAATCATCGATGAGAATGGAGTTCATGAGCTG GTGAAAAATGGTATTTGA PF01704 UDPGP function transferase activity function transferase activity, transferring phosphorus-containing groups function nucleotidyltransferase activity function catalytic activity process metabolism process physiological process BE0001252 UDP-N-acetylglucosamine 1-carboxyvinyltransferase Shigella flexneri # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-N-acetylglucosamine 1-carboxyvinyltransferase Cell wall/membrane/envelope biogenesis Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA Cytoplasm (Probable) None 6.07 44818.0 Shigella flexneri GenBank Gene Database AE005674 GenBank Protein Database 24053661 UniProtKB P0A751 UniProt Accession MURA_SHIFL EC 2.5.1.7 Enoylpyruvate transferase EPT UDP-N-acetylglucosamine enolpyruvyl transferase >UDP-N-acetylglucosamine 1-carboxyvinyltransferase MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE >1260 bp TTACTCGCCTTTCACACGCTCAATATTTGCACCTAAAGCGCGCAGTTTGTCTTCAATGCG TTCGTAGCCACGATCGATGTGATAAATACGATCAACCACCGTCGTCCCTTCCGCAATACA GCCAGCCAGCACCAGGCTTGCTGATGCACGCAGATCGGTTGCCATAACCTGTGCACCAGA AAGTTTTTCAACACCATGACAAATAACGGTATTGCTTTCGATTTCGGCGTGCGCGCCCAT ACGGCTCAGCTCTGGCACATGCATAAAGCGGTTTTCAAAGACCGTTTCGGTGATGAACCC GGTCCCTTCAGCCACCAGGTTCAACAGCGTGAACTGGGCCTGCATATCGGTCGGGAATGC CGGATGCGGCGCGGTACGTACGTTAACAGCCTTCGGACGTTTGCCATGCATATCCAGGCT AATCCAGTCTTCGCCGACTTCGATGTCCGCTCCAGCATCACGCAGTTTCGCCAGCACGGC GTCCAGAGTATCTGGCTGCGCGTTACGGCAGATAATTTTGCCACGAGAGATCGCCGCCGC CACCAGGAAAGTACCGGTTTCGATACGATCCGGCAGCACGCGATAGACACCGCCGCCTAA ACGTTCCACACCTTCGATGACGATACGATCGGTGCCCTGACCGCTAATTTTCGCACCCAG CGTAATCAGGAAGTTCGCGGTATCGACGATTTCCGGTTCACGCGCTGCGTTTTCAATAAT CGTGGTGCCTTCCGCCAGGGTTGCAGCACACATGATGGTCACCGTTGCGCCAACGCTGAC TTTATCCATCACGATATGTGCGCCTTTCAGACGACCATCGACGGAAGCTTTAACGTAACC TTCTTCCAGTTTGATGGTCGCGCCTAATTGTTCGAGGCCAGAAATGTGTAGATCAACCGG ACGCGCACCGATCGTACAACCGCCAGGTAGTGAAACTTGCCCCTGACCAAAGCGCGCTAC CAGCGGCCCCAGCGCCCAGATAGAAGCACGCATGGTTTTAACCAGATCGTAAGGTGCGCA GAATACATTAACGTCGCGGGCATCAATATGCACAGAACCATTACGTTCTACTTTCGCACC CAGCTGGCTTAGCAGTTTCATTGATGTATCGACGTCTTTCAGTTTCGGGACGTTCTGGAT CTCTACCGGTTCTTCCGCCAGTAGTGCGGCAAAAAGAATAGGCAGAGCAGCATTTTTAGC GCCGGAAATTGTGACTTCGCCCTGGAGCTTCGTTGGCCCCTGAACACGAAATTTATCCAT PF00275 EPSP_synthase function catalytic activity function transferase activity process amino sugar metabolism process UDP-N-acetylgalactosamine metabolism process UDP-N-acetylgalactosamine biosynthesis process physiological process process metabolism process nitrogen compound metabolism process amine metabolism BE0001521 UDP-glucose 4-epimerase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-glucose 4-epimerase Cell wall/membrane/envelope biogenesis Catalyzes two distinct but analogous reactions:the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine GALE 1p36-p35 None 6.71 38282.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:4116 GenAtlas GALE GeneCards GALE GenBank Gene Database L41668 GenBank Protein Database 1119217 UniProtKB Q14376 UniProt Accession GALE_HUMAN EC 5.1.3.2 Galactowaldenase UDP-galactose 4-epimerase >UDP-glucose 4-epimerase MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA >1047 bp ATGGCAGAGAAGGTGCTGGTAACAGGTGGGGCTGGCTACATTGGCAGCCACACGGTGCTG GAGCTGCTGGAGGCTGGCTACTTGCCTGTGGTCATCGATAACTTCCATAATGCCTTCCGT GGAGGGGGCTCCCTGCCTGAGAGCCTGCGGCGGGTCCAGGAGCTGACAGGCCGCTCTGTG GAGTTTGAGGAGATGGACATTTTGGACCAGGGAGCCCTACAGCGTCTCTTCAAAAAGTAC AGCTTTATGGCGGTCATCCACTTTGCGGGGCTCAAGGCCGTGGGCGAGTCGGTGCAGAAG CCTCTGGATTATTACAGAGTTAACCTGACCGGGACCATCCAGCTTCTGGAGATCATGAAG GCCCACGGGGTGAAGAACCTGGTGTTCAGCAGCTCAGCCACTGTGTACGGGAACCCCCAG TACCTGCCCCTTGATGAGGCCCACCCCACGGGTGGTTGTACCAACCCTTACGGCAAGTCC AAGTTCTTCATCGAGGAAATGATCCGGGACCTGTGCCAGGCAGACAAGACTTGGAACGTA GTGCTGCTGCGCTATTTCAACCCCACAGGTGCCCATGCCTCTGGCTGCATTGGTGAGGAT CCCCAGGGCATACCCAACAACCTCATGCCTTATGTCTCCCAGGTGGCGATCGGGCGACGG GAGGCCCTGAATGTCTTTGGCAATGACTATGACACAGAGGATGGCACAGGTGTCCGGGAT TACATCCATGTCGTGGATCTGGCCAAGGGCCACATTGCAGCCTTAAGGAAGCTGAAAGAA CAGTGTGGCTGCCGGATCTACAACCTGGGCACGGGCACAGGCTATTCAGTGCTGCAGATG GTCCAGGCTATGGAGAAGGCCTCTGGGAAGAAGATCCCGTACAAGGTGGTGGCACGGCGG GAAGGTGATGTGGCAGCCTGTTACGCCAACCCCAGCCTGGCCCAAGAGGAGCTGGGGTGG ACAGCAGCCTTAGGGCTGGACAGGATGTGTGAGGATCTCTGGCGCTGGCAGAAGCAGAAT CCTTCAGGCTTTGGCACGCAAGCCTGA PF01370 Epimerase function catalytic activity function NAD binding function racemase and epimerase activity function cofactor binding function racemase and epimerase activity, acting on carbohydrates and derivatives function coenzyme binding function UDP-glucose 4-epimerase activity function isomerase activity function binding process monosaccharide metabolism process hexose metabolism process metabolism process cellular metabolism process nucleotide-sugar metabolism process macromolecule metabolism process galactose metabolism process carbohydrate metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process alcohol metabolism process physiological process BE0003075 Bifunctional protein GlmU Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) unknown Bifunctional protein GlmU Involved in UDP-N-acetylglucosamine diphosphorylase activity Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc (Probable) glmU Cytoplasm None 5.43 49345.0 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GenBank Gene Database AE005672 UniProtKB Q97R46 UniProt Accession GLMU_STRPN >Bifunctional protein glmU MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGHKAELVE EVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLITGESLKNLIDFHIN HKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATDFEKQIKEINTGTYVFDNERL FEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMR RRINHKHMVNGVSFVNPEATYIDIDVEIASEVQIEANVTLKGQTKIGAETVLTNGTYVVD STIGAGAVITNSMIEESSVADGVIVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGENTKA GHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGNNVFVGSNSTIIAPVELGDNSLV GAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHPKNQ >1380 bp ATGTCAAATTTTGCCATTATTTTAGCAGCGGGTAAAGGGACTCGCATGAAATCTGATTTG CCAAAAGTTTTGCACAAGGTTGCGGGTATTTCTATGTTGGAACATGTTTTCCGTAGTGTG GGAGCTATCCAACCTGAAAAGACAGTAACAGTTGTAGGACACAAGGCAGAATTGGTTGAG GAGGTCTTGGCTGGACAGACAGAATTTGTGACTCAATCTGAACAGTTGGGAACTGGTCAT GCAGTTATGATGACAGAGCCTATCTTAGAAGGTTTGTCAGGACACACCTTGGTCATTGCA GGAGATACTCCTTTAATCACTGGTGAAAGCTTGAAAAACTTGATTGATTTCCATATCAAT CATAAAAATGTGGCCACTATCTTGACTGCTGAAACGGATAATCCTTTTGGTTATGGACGA ATTGTTCGTAATGACAATGCTGAGGTTCTTCGTATTGTTGAGCAGAAGGATGCTACAGAT TTTGAAAAGCAAATCAAGGAAATCAACACTGGAACATACGTCTTTGACAACGAGCGTTTG TTTGAGGCTTTGAAAAATATCAATACCAATAACGCTCAAGGCGAATACTATATTACAGAC GTCATTGGTATTTTCCGTGAAACTGGTGAAAAAGTTGGCGCTTATACTTTGAAAGATTTT GATGAAAGTCTTGGGGTAAATGACCGTGTGGCGCTTGCGACAGCTGAGTCAGTTATGCGT CGTCGCATCAATCATAAACACATGGTCAACGGTGTTAGCTTTGTCAATCCAGAAGCAACT TATATCGATATTGATGTTGAGATTGCTTCGGAAGTTCAAATCGAAGCCAATGTTACCTTG AAAGGGCAAACGAAAATTGGTGCTGAGACTGTTTTGACAAACGGTACTTATGTAGTGGAC AGCACTATCGGAGCAGGAGCGGTCATTACCAATTCTATGATTGAGGAAAGTAGTGTTGCA GACGGTGTGATAGTCGGTCCTTATGCTCACATTCGTCCAAATTCAAGTCTGGGTGCCCAA GTTCATATTGGTAACTTTGTTGAGGTGAAAGGATCTTCAATCGGTGAGAATACCAAGGCT GGTCATTTGACTTATATCGGAAACTGTGAAGTGGGAAGCAACGTTAATTTCGGTGCTGGA ACTATTACAGTCAACTATGACGGCAAAAACAAATACAAGACAGTCATTGGAAACAATGTC TTTGTTGGTTCAAATTCAACCATTATTGCACCAGTAGAACTTGGTGACAATTCCCTCGTT GGTGCTGGTTCAACTATTACTAAAGACGTGCCAGCAGATGCTATTGCTATTGGTCGCGGT CGTCAGATCAATAAAGACGAATATGCAACACGTCTTCCTCATCATCCTAAGAACCAGTAG PF00132 Hexapep PF01128 IspD function transferase activity function transferase activity, transferring phosphorus-containing groups function 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity function UDP-N-acetylglucosamine diphosphorylase activity function nucleotidyltransferase activity function catalytic activity process isoprenoid biosynthesis process metabolism process carbohydrate biosynthesis process macromolecule metabolism process polysaccharide biosynthesis process lipopolysaccharide biosynthesis process macromolecule biosynthesis process primary metabolism process lipid metabolism process cellular lipid metabolism process physiological process process isoprenoid metabolism BE0001901 UDP-glucose 4-epimerase Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-glucose 4-epimerase Cell wall/membrane/envelope biogenesis UDP-glucose = UDP-galactose galE None 6.32 37266.0 Escherichia coli (strain K12) GenBank Gene Database X06226 GenBank Protein Database 41523 UniProtKB P09147 UniProt Accession GALE_ECOLI EC 5.1.3.2 Galactowaldenase UDP-galactose 4-epimerase >UDP-glucose 4-epimerase MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD >1017 bp ATGAGAGTTCTGGTTACCGGTGGTAGCGGTTACATTGGAAGTCATACCTGTGTGCAATTA CTGCAAAACGGTCATGATGTCATCATTCTTGATAACCTCTGTAACAGTAAGCGCAGCGTA CTGCCTGTTATCGAGCGTTTAGGCGGCAAACATCCAACGTTTGTTGAAGGCGATATTCGT AACGAAGCGTTGATGACCGAGATCCTGCACGATCACGCTATCGACACCGTGATCCACTTC GCCGGGCTGAAAGCCGTGGGCGAATCGGTACAAAAACCGCTGGAATATTACGACAACAAT GTCAACGGCACTCTGCGCCTGATTAGCGCCATGCGCGCCGCTAACGTCAAAAACTTTATT TTTAGCTCCTCCGCCACCGTTTATGGCGATCAGCCCAAAATTCCATACGTTGAAAGCTTC CCGACCGGCACACCGCAAAGCCCTTACGGCAAAAGCAAGCTGATGGTGGAACAGATCCTC ACCGATCTGCAAAAAGCCCAGCCGGACTGGAGCATTGCCCTGCTGCGCTACTTCAACCCG GTTGGCGCGCATCCGTCGGGCGATATGGGCGAAGATCCGCAAGGCATTCCGAATAACCTG ATGCCATACATCGCCCAGGTTGCTGTAGGCCGTCGCGACTCGCTGGCGATTTTTGGTAAC GATTATCCGACCGAAGATGGTACTGGCGTACGCGATTACATCCACGTAATGGATCTGGCG GACGGTCACGTCGTGGCGATGGAAAAACTGGCGAACAAGCCAGGCGTACACATCTACAAC CTCGGCGCTGGCGTAGGCAACAGCGTGCTGGACGTGGTTAATGCCTTCAGCAAAGCCTGC GGCAAACCGGTTAATTATCATTTTGCACCGCGTCGCGAGGGCGACCTTCCGGCCTACTGG GCGGACGCCAGCAAAGCCGACCGTGAACTGAACTGGCGCGTAACGCGCACACTCGATGAA ATGGCGCAGGACACCTGGCACTGGCAGTCACGCCATCCACAGGGATATCCCGATTAA PF01370 Epimerase function coenzyme binding function UDP-glucose 4-epimerase activity function isomerase activity function binding function NAD binding function catalytic activity function racemase and epimerase activity function racemase and epimerase activity, acting on carbohydrates and derivatives function cofactor binding process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process alcohol metabolism process monosaccharide metabolism process hexose metabolism process physiological process process nucleotide-sugar metabolism process metabolism process cellular metabolism process galactose metabolism BE0004629 Exostosin-like 2 Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Exostosin-like 2 EXTL2 Human UniProtKB Q9UBQ6 UniProt Accession EXTL2_HUMAN BE0004519 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase MGAT1 Human UniProtKB P26572 UniProt Accession MGAT1_HUMAN "
owl:sameAs

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

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