Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB03280"
| Predicate | Value (sorted: none) |
|---|---|
| rdfs:label |
"P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate"
|
| owl:sameAs | |
| drugbank:description |
"
experimental
This compound belongs to the pyrimidine 2'-deoxyribonucleoside polyphosphates. These are pyrimidine nucleotides with a polyphosphate (with 4 or more phosphate) group linked to the ribose moiety lacking an hydroxyl group at position 2.
Pyrimidine 2'-deoxyribonucleoside Polyphosphates
Organic Compounds
Organooxygen Compounds
Carbohydrates and Carbohydrate Conjugates
Glycosyl Compounds
Purine Nucleosides and Analogues
Pentose Phosphates
Organic Pyrophosphates
Monosaccharide Phosphates
Purines and Purine Derivatives
Aminopyrimidines and Derivatives
Pyrimidones
Primary Aromatic Amines
Organic Phosphoric Acids
Organophosphate Esters
N-substituted Imidazoles
Hydropyrimidines
Tetrahydrofurans
Oxolanes
1,2-Diols
Secondary Alcohols
Ethers
Polyamines
pentose phosphate
pentose-5-phosphate
pentose monosaccharide
monosaccharide phosphate
organic pyrophosphate
imidazopyrimidine
purine
aminopyrimidine
pyrimidone
hydropyrimidine
primary aromatic amine
phosphoric acid ester
monosaccharide
organic phosphate
n-substituted imidazole
pyrimidine
tetrahydrofuran
oxolane
azole
imidazole
secondary alcohol
1,2-diol
polyamine
ether
amine
organonitrogen compound
primary amine
alcohol
logP
0.44
ALOGPS
logS
-2.1
ALOGPS
Water Solubility
6.30e+00 g/l
ALOGPS
logP
-8.4
ChemAxon
IUPAC Name
[({[({[({[(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl)oxy]({[(2S,3R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphinic acid
ChemAxon
Traditional IUPAC Name
{[({[(2S,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy(hydroxy)phosphoryl]oxy(hydroxy)phosphoryl}oxy[(2S,3R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3H-pyrimidin-1-yl)oxolan-2-yl]methoxyphosphinic acid
ChemAxon
Molecular Weight
891.3541
ChemAxon
Monoisotopic Weight
891.008112861
ChemAxon
SMILES
CC1=CN([C@H]2C[C@@H](O)[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P@@](O)(=O)O[P@](O)(=O)O[P@@](O)(=O)OC[C@@H]3O[C@H]([C@H](O)[C@H]3O)N3C=NC4=C3N=CN=C4N)O2)C(=O)NC1=O
ChemAxon
Molecular Formula
C20H30N7O23P5
ChemAxon
InChI
InChI=1S/C20H30N7O23P5/c1-8-3-26(20(32)25-18(8)31)12-2-9(28)10(45-12)4-43-51(33,34)47-53(37,38)49-55(41,42)50-54(39,40)48-52(35,36)44-5-11-14(29)15(30)19(46-11)27-7-24-13-16(21)22-6-23-17(13)27/h3,6-7,9-12,14-15,19,28-30H,2,4-5H2,1H3,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,22,23)(H,25,31,32)/t9-,10+,11+,12-,14+,15-,19-/m1/s1
ChemAxon
InChIKey
InChIKey=JCFDSPQTEMXXLO-MZWJRZEOSA-N
ChemAxon
Polar Surface Area (PSA)
440.06
ChemAxon
Refractivity
169.19
ChemAxon
Polarizability
69.54
ChemAxon
Rotatable Bond Count
16
ChemAxon
H Bond Acceptor Count
21
ChemAxon
H Bond Donor Count
10
ChemAxon
pKa (strongest acidic)
0.42
ChemAxon
pKa (strongest basic)
5
ChemAxon
Physiological Charge
-5
ChemAxon
Number of Rings
5
ChemAxon
Bioavailability
0
ChemAxon
MDDR-Like Rule
true
ChemAxon
PubChem Compound
46936628
PubChem Substance
46505960
PDB
T5A
BE0001221
Thymidylate kinase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Thymidylate kinase
Nucleotide transport and metabolism
Catalyzes the conversion of dTMP to dTDP
DTYMK
2q37.3
None
8.49
23820.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:3061
GenAtlas
DTYMK
GeneCards
DTYMK
GenBank Gene Database
X54729
GenBank Protein Database
37206
UniProtKB
P23919
UniProt Accession
KTHY_HUMAN
dTMP kinase
EC 2.7.4.9
>Thymidylate kinase
MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKK
SDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQP
DVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDA
SKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
>636 bp
ATGGCGGCCCGGCGCGGGGCTCTCATAGTGCTGGAGGGCGTGGACCGCGCCGGGAAGAGC
ACGCAGAGCCGCAAGCTGGTGGAAGCGCTGTCGCGCGGGCCACCGCCCGAACTGCTCCGG
TTCCCGGAAAGATCAACTGAAATCGGCAAACTTCTGAGTTCCTACTTGCAAAAGAAAAGT
GACGTGGAGGATCACTCGGTGCACCTGCTTTTTTCTGCAAATCGCTGGGAACAAGTGCCG
TTAATTAAGGAAAAGTTGAGCCAGGGCGTGACCCTCGTCGTGGACAGATACGCATTTTCT
GGTGTGGCCTTCACCGGTGCCAAGGAGAATTTTTCCCTAGACTGGTGTAAACAGCCAGAC
GTGGGCCTTCCCAAACCCGACCTGGTCCTGTTCCTCCAGTTACAGCTGGCGGATGCTGCC
AAGCGGGGAGCGTTTGGCCATGAGCGCTATGAGAACGGGGCTTTCCAGGAGCGGGCGCTC
CGGTGTTTCCACCAGCTCATGAAAGACACGACTTTGAACTGGAAGATGGTGGATGCTTCC
AAAAGACTCGAAGCTGTCCATGAGGAACTCCGCGTGCTCTCTGAGGACGCCATCCGCACT
GCCACAGAGAAGCCGCTGGGGGAGCTATGGAAGTGA
PF02223
Thymidylate_kin
function
catalytic activity
function
phosphotransferase activity, phosphate group as acceptor
function
nucleotide binding
function
thymidylate kinase activity
function
purine nucleotide binding
function
adenyl nucleotide binding
function
transferase activity
function
ATP binding
function
transferase activity, transferring phosphorus-containing groups
function
binding
process
nucleotide metabolism
process
pyrimidine nucleotide metabolism
process
metabolism
process
pyrimidine nucleotide biosynthesis
process
cellular metabolism
process
pyrimidine nucleoside triphosphate biosynthesis
process
pyrimidine deoxyribonucleoside triphosphate biosynthesis
process
dTTP biosynthesis
process
pyrimidine nucleoside diphosphate biosynthesis
process
pyrimidine deoxyribonucleoside diphosphate biosynthesis
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
dTDP biosynthesis
process
physiological process
BE0001932
Thymidylate kinase
Shigella flexneri
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidylate kinase
Nucleotide transport and metabolism
Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth
tmk
None
5.16
23783.0
Shigella flexneri
GenBank Gene Database
AE005674
GenBank Protein Database
24051392
UniProtKB
P0A721
UniProt Accession
KTHY_SHIFL
dTMP kinase
EC 2.7.4.9
Thymidine monophosphate kinase
TMPK
>Thymidylate kinase
MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSV
GDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHML
ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ
DKSIHTIDATQPLEAVMDAIRTTVTHWVKELDA
>642 bp
ATGCGCAGTAAGTATATCGTCATTGAGGGGCTGGAAGGCGCAGGCAAAACTACCGCGCGT
AATGTGGTGGTTGAGACGCTCGAGCAACTGGGTATCCGCGACATGGTTTTCACTCGGGAA
CCTGGCGGTACGCAACTTGCCGAAAAGTTAAGAAGCCTGGTGCTGGATATCAAATCGGTA
GGCGATGAAGTCATTACCGATAAAGCCGAAGTTCTGATGTTTTATGCCGCGCGCGTTCAA
CTGGTAGAAACGGTCATCAAACCTGCGCTGGCTAACGGCACCTGGGTGATTGGCGATCGC
CACGATCTTTCCACTCAGGCGTATCAGGGCGGAGGACGTGGTATTGACCAACATATGCTG
GCAACACTGCGTGATGCTGTTCTCGGGGATTTTCGCCCAGACTTAACGCTCTATCTCGAT
GTTACCCCGGAAGTTGGCTTAAAACGCGCGCGTGCGCGCGGCGAGCTGGATCGTATTGAG
CAAGAGTCTTTCGATTTCTTTAATCGCACCCGCGCCCGCTATCTGGAACTGGCTGCACAA
GATAAAAGTATTCATACCATTGATGCCACCCAGCCGCTGGAGGCCGTGATGGATGCAATC
CGCACTACCGTGACCCACTGGGTGAAGGAGTTGGACGCATGA
PF02223
Thymidylate_kin
function
purine nucleotide binding
function
adenyl nucleotide binding
function
transferase activity
function
ATP binding
function
transferase activity, transferring phosphorus-containing groups
function
binding
function
catalytic activity
function
phosphotransferase activity, phosphate group as acceptor
function
nucleotide binding
function
thymidylate kinase activity
process
pyrimidine nucleoside triphosphate biosynthesis
process
pyrimidine deoxyribonucleoside triphosphate biosynthesis
process
dTTP biosynthesis
process
pyrimidine nucleoside diphosphate biosynthesis
process
pyrimidine deoxyribonucleoside diphosphate biosynthesis
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
dTDP biosynthesis
process
physiological process
process
nucleotide metabolism
process
pyrimidine nucleotide metabolism
process
metabolism
process
pyrimidine nucleotide biosynthesis
process
cellular metabolism
BE0001929
Thymidine kinase
EHV-4
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidine kinase
Involved in thymidine kinase activity
ATP + thymidine = ADP + thymidine 5'- phosphate
TK
None
7.19
38785.0
EHV-4
GenBank Gene Database
D14486
GenBank Protein Database
221822
UniProtKB
P24425
UniProt Accession
KITH_EHV4
EC 2.7.1.21
>Thymidine kinase
MAACVPPGEAPRSASGTPTRRQVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPE
PMAYWRTLFETDVISGIYDTQNRKQQGNLAVDDAALITAHYQSRFTTPYLILHDHTCTLF
GGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIV
VTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPT
SCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRN
LNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
>1059 bp
ATGGCTGCTTGCGTACCCCCGGGAGAAGCTCCACGAAGCGCCAGCGGAACGCCCACCCGG
CGGCAAGTAACAATAGTTAGAATTTACCTCGATGGAGTTTATGGCATCGGTAAGAGCACG
ACGGGACGAGTTATGGCATCGGCTGCTAGCGGAGGAAGTCCAACTCTATACTTTCCAGAG
CCTATGGCGTACTGGCGGACTCTTTTTGAAACGGACGTAATTAGTGGTATTTACGACACC
CAAAACCGGAAACAGCAGGGAAATTTGGCCGTTGATGACGCGGCATTAATAACTGCGCAT
TACCAAAGCCGCTTTACCACGCCCTACCTGATACTCCACGATCACACTTGTACGTTGTTT
GGGGGAAACAGCCTACAGCGTGGAACACAACCGGACCTGACCCTTGTGTTTGACCGCCAC
CCGGTCGCCTCTACCGTATGCTTTCCAGCAGCCCGCTACCTACTCGGTGACATGTCAATG
TGCGCGCTAATGGCTATGGTTGCTACTCTACCAAGAGAACCCCAGGGTGGTAACATTGTG
GTTACCACCCTAAATGTAGAGGAGCATATACGGAGACTGCGTACGCGGGCTAGAATAGGA
GAACAAATTGACATTACGCTGATTGCTACATTGCGAAATGTGTACTTTATGCTAGTTAAT
ACATGTCACTTTTTGCGCTCTGGGCGAGTTTGGCGCGACGGTTGGGGTGAGCTACCCACT
TCCTGTGGGGCTTATAAGCATCGCGCCACACAGATGGACGCCTTCCAAGAGCGCGTTTCA
CCGGAGCTGGGCGACACTCTGTTTGCCCTGTTTAAAACTCAAGAACTGCTAGACGATCGC
GGTGTAATATTGGAAGTTCACGCTTGGGCGTTGGACGCGCTTATGCTAAAACTGCGTAAC
CTGAATGTTTTCAGTGCCGATTTAAGTGGTACACCGCGACAATGTGCAGCTGTTGTAGAG
TCTTTGCTGCCACTTATGAGCAGCACCTTATCAGATTTTGATTCCGCCTCTGCTTTAGAG
CGGGCGGCACGCACCTTTAACGCGGAGATGGGCGTCTGA
PF00693
Herpes_TK
function
nucleotide binding
function
purine nucleotide binding
function
adenyl nucleotide binding
function
nucleobase, nucleoside, nucleotide kinase activity
function
transferase activity
function
nucleoside kinase activity
function
ATP binding
function
deoxynucleoside kinase activity
function
transferase activity, transferring phosphorus-containing groups
function
thymidine kinase activity
function
binding
function
kinase activity
function
catalytic activity
process
pyrimidine nucleoside monophosphate biosynthesis
process
pyrimidine ribonucleoside monophosphate biosynthesis
process
TMP biosynthesis
process
physiological process
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
metabolism
process
pyrimidine nucleotide metabolism
process
cellular metabolism
process
pyrimidine nucleotide biosynthesis
BE0001403
Thymidine kinase
HHV-1
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidine kinase
Involved in thymidine kinase activity
In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome
TK
-
None
7.96
40973.0
HHV-1
GenBank Gene Database
X14112
GenBank Protein Database
59524
UniProtKB
P03176
UniProt Accession
KITH_HHV11
EC 2.7.1.21
>Thymidine kinase
MASYPCHQHASAFDQAARSRGHNNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQCGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN
>1131 bp
TCAGTTAGCCTCCCCCATCTCCCGGGCAAACGTGCGCGCCAGGTCGCAGATCGTCGGTAT
GGAGCCTGGGGTGGTGACGTGGGTCTGGACCATCCCGGAGGTAAGTTGCAGCAGGGCGTC
CCGGCAGCCGGCGGGCGATTGGTCGTAATCCAGGATAAAGACATGCATGGGACGGAGGCG
TTTGGCCAAGACGTCCAAAGCCCAGGCAAACACGTTATACAGGTCGCCGTTGGGGGCCAG
CAACTCGGGGGCCCGAAACAGGGTAAATAACGTGTCCCCGATATGGGGTCGTGGGCCCGC
GTTGCTCTGGGGCTCGGCACCCTGGGGCGGCACGGCCGCCCCCGAAAGCTGTCCCCAATC
CTCCCGCCACGACCCGCCGCCCTGCAGATACCGCACCGTATTGGCAAGCAGCCCATAAAC
GCGGCGAATCGCGGCCAGCATAGCCAGGTCAAGCCGCTCGCCGGGGCGCTGGCGTTTGGC
CAGGCGGTCGATGTGTCTGTCCTCCGGAAGGGCCCCCAACACGATGTTTGTGCCGGGCAA
GGTCGGCGGGATGAGGGCCACGAACGCCAGCACGGCCTGGGGGGTCATGCTGCCCATAAG
GTATCGCGCGGCCGGGTAGCACAGGAGGGCGGCGATGGGATGGCGGTCGAAGATGAGGGT
GAGGGCCGGGGGCGGGGCATGTGAGCTCCCAGCCTCCCCCCCGATATGAGGAGCCAGAAC
GGCGTCGGTCACGGCATAAGGCATGCCCATTGTTATCTGGGCGCTTGTCATTACCACCGC
CGCGTCCCCGGCCGATATCTCACCCTGGTCGAGGCGGTGTTGTGTGGTGTAGATGTTCGC
GATTGTCTCGGAAGCCCCCAACACCCGCCAGTAAGTCATCGGCTCGGGTACGTAGACGAT
ATCGTCGCGCGAACCCAGGGCCACCAGCAGTTGCGTGGTGGTGGTTTTCCCCATCCCGTG
GGGACCGTCTATATAAACCCGCAGTAGCGTGGGCATTTTCTGCTCCAGGCGGACTTCCGT
GGCTTTTTGTTGCCGGCGAGGGCGCAACGCCGTACGTCGGTTGTTATGGCCGCGAGAACG
CGCAGCCTGGTCGAACGCAGACGCGTGTTGATGGCAGGGGTACGAAGCCAT
PF00693
Herpes_TK
function
catalytic activity
function
nucleotide binding
function
purine nucleotide binding
function
adenyl nucleotide binding
function
nucleobase, nucleoside, nucleotide kinase activity
function
transferase activity
function
nucleoside kinase activity
function
ATP binding
function
deoxynucleoside kinase activity
function
transferase activity, transferring phosphorus-containing groups
function
thymidine kinase activity
function
binding
function
kinase activity
process
nucleotide metabolism
process
metabolism
process
pyrimidine nucleotide metabolism
process
cellular metabolism
process
pyrimidine nucleotide biosynthesis
process
pyrimidine nucleoside monophosphate biosynthesis
process
pyrimidine ribonucleoside monophosphate biosynthesis
process
TMP biosynthesis
process
physiological process
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
BE0001218
Thymidylate kinase
Mycobacterium tuberculosis
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Thymidylate kinase
Nucleotide transport and metabolism
Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth. Has a broad specificity for nucleoside triphosphates, being highly active with ATP or dATP as phosphate donors, and less active with ITP, GTP, CTP and UTP
tmk
None
7.66
22635.0
Mycobacterium tuberculosis
GenBank Gene Database
BX842582
GenBank Protein Database
2072714
UniProtKB
O05891
UniProt Accession
KTHY_MYCTU
dTMP kinase
EC 2.7.4.9
Thymidine monophosphate kinase
TMPK
>Thymidylate kinase
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
>645 bp
TCAACTTGGCACGTCTGGAGGCGCCAAAGTCGCCGCTAGTCGGCCCGGATCAACATCGGC
GCCGACAACCAGCCACCGGCCGCCCCACCCTTGGGCCGCCAACTCGGCGTAGACCGCACC
GGTGCGCTGCTGAAGTTCAGCGTCGCGTTCGTAATTGTCGCGCGCCCGACCGGGGTCACG
CTGGGCACGGCCGCGGGATCGTTCCCCGGCGAGCTCGGCAGAGACCGCAAGGAGCACCTG
CCAGTCGGGCTTGGGCAACCCGAGTCTTGCAAATTCGATCCGCTGAACCCAGGCCGCTGC
CTTCCCGGCCGCGTTTTCATGTAGGCGCGCCGCGCTGTAGGCCGCGTTGGAGGCGACGTA
GCGATCCAGGATCACCACGTCGTAGCCGCGACACAGCCCCTGGATCGTGTGGACCGCGCC
AGCGCGGTCGAGCGCGAACAGCGTCGCCATCGCATACACCGACGATGCGAGGTCACCGTG
CTCGCCGTGCAGCGCCTCCGCTGCGATGTCGGCGGCCACCGACTGTCCGTAGCGCGGGAA
CGCCAGTGTGGCCACCGATCTCCCGGCTGCTCGAAAGGCCCCGGACAGCTTTTCCACCAA
CGTCCGCTTGCCAGCGCCGTCAACGCCCTCAATCGCGATTAGCAC
PF02223
Thymidylate_kin
function
purine nucleotide binding
function
adenyl nucleotide binding
function
transferase activity
function
ATP binding
function
transferase activity, transferring phosphorus-containing groups
function
binding
function
catalytic activity
function
phosphotransferase activity, phosphate group as acceptor
function
nucleotide binding
function
thymidylate kinase activity
process
pyrimidine nucleoside triphosphate biosynthesis
process
pyrimidine deoxyribonucleoside triphosphate biosynthesis
process
dTTP biosynthesis
process
pyrimidine nucleoside diphosphate biosynthesis
process
pyrimidine deoxyribonucleoside diphosphate biosynthesis
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
dTDP biosynthesis
process
physiological process
process
nucleotide metabolism
process
pyrimidine nucleotide metabolism
process
metabolism
process
pyrimidine nucleotide biosynthesis
process
cellular metabolism
"
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| rdf:type |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object