Resource Geranyl Diphosphate

Predicate	Value (sorted: none)
owl:sameAs	drug:Simvastatin
rdfs:label	"Geranyl Diphosphate"
drugbank:description	" experimental Oscar Alvizo, Robert McDaniel, Benjamin Mijts, "PRODUCTION OF GERANYL DIPHOSPHATE." U.S. Patent US20130011888, issued January 10, 2013. This compound belongs to the isoprenoid phosphates. These are prenol lipids containing a phosphate group linked to an isoprene unit. Isoprenoid Phosphates Organic Compounds Lipids Prenol Lipids Isoprenoid Phosphates Acyclic Monoterpenes Organic Pyrophosphates Organophosphate Esters Organic Phosphoric Acids Polyamines organic phosphate phosphoric acid ester polyamine logP 1.63 ALOGPS logS -2.5 ALOGPS Water Solubility 9.02e-01 g/l ALOGPS logP 1.96 ChemAxon IUPAC Name [({[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid ChemAxon Traditional IUPAC Name {[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy(hydroxy)phosphoryl}oxyphosphonic acid ChemAxon Molecular Weight 314.2091 ChemAxon Monoisotopic Weight 314.068426018 ChemAxon SMILES CC(C)=CCC\C(C)=C\CO[P@@](=O)(O)OP(=O)(O)O ChemAxon Molecular Formula C10H20O7P2 ChemAxon InChI InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+ ChemAxon InChIKey InChIKey=GVVPGTZRZFNKDS-JXMROGBWSA-N ChemAxon Polar Surface Area (PSA) 113.29 ChemAxon Refractivity 72.93 ChemAxon Polarizability 28.52 ChemAxon Rotatable Bond Count 8 ChemAxon H Bond Acceptor Count 5 ChemAxon H Bond Donor Count 3 ChemAxon pKa (strongest acidic) 1.77 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon ChEBI 17211 PubChem Compound 445995 PubChem Substance 46504900 KEGG Compound C00341 ChemSpider 393471 PDB GPP SMP00319 Lysosomal Acid Lipase Deficiency (Wolman Disease) DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00510 Mevalonic aciduria DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00131 Atorvastatin Action Pathway DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00089 Pravastatin Action Pathway DB00169 Cholecalciferol DB00175 Pravastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00082 Simvastatin Action Pathway DB00169 Cholecalciferol DB00641 Simvastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00095 Alendronate Action Pathway DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00107 Zoledronate Action Pathway DB00169 Cholecalciferol DB00399 Zoledronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00112 Risedronate Action Pathway DB00169 Cholecalciferol DB00884 Risedronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00092 Rosuvastatin Action Pathway DB00169 Cholecalciferol DB01098 Rosuvastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00099 Lovastatin Action Pathway DB00169 Cholecalciferol DB00227 Lovastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00117 Pamidronate Action Pathway DB00169 Cholecalciferol DB00282 Pamidronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00079 Ibandronate Action Pathway DB00169 Cholecalciferol DB00710 Ibandronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00119 Fluvastatin Action Pathway DB00169 Cholecalciferol DB01095 Fluvastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00111 Cerivastatin Action Pathway DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00023 Steroid Biosynthesis DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00388 Chondrodysplasia Punctata II, X Linked Dominant (CDPX2) DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00387 CHILD Syndrome DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00508 Cholesteryl ester storage disease DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00386 Desmosterolosis DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00511 Wolman disease DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00509 Hyper-IgD syndrome DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00209 Hypercholesterolemia DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00389 Smith-Lemli-Opitz Syndrome (SLOS) DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 BE0001303 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Shigella flexneri # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid transport and metabolism Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP ispF None 6.51 16898.0 Shigella flexneri GenBank Gene Database AE005674 GenBank Protein Database 24053164 UniProtKB P62619 UniProt Accession ISPF_SHIFL EC 4.6.1.12 MECDP-synthase MECPS >2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK >480 bp TCATTTTGTTGCCTTAATGAGTAGCGCCACCGCTTCACAGGCAATCCCTTCCCCACGTCC GGTAAATCCAAGTTTTTCCGTAGTAGTGGCTTTCACGTTAACATCATCCATATGGCAGCC GAGATCTTCGGCAATAAACACGCGCATTTGTGGAATGTGCGGCAACATCTTCGGTGCCTG AGCGATGATAGTGACATCGACGTTGCCAAGGGTATAACCCTTCGCCTGAATACGACGCCA GGCTTCGCGTAGCAGCTCGCGGCTGTCGGCACCTTTAAATGCCGGATCGGTATCCGGGAA CAGTTTGCCGATATCCCCCAGCGCCGCCGCGCCAAGCAATGCATCGGTCAACGCATGAAG CGCCACGTCGCCATCAGAATGCGCCAGCAATCCTTTTTCGTAAGGAATGCGTACGCCACC AATGATAATTGGGCCTTCACCGCCAAAGGCGTGTACGTCAAAACCGTGTCCAATTCGCAT PF02542 YgbB function lyase activity function phosphorus-oxygen lyase activity function 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity function catalytic activity process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism process polyisoprenoid metabolism process physiological process process terpenoid metabolism process terpenoid biosynthesis BE0001748 Bifunctional enzyme IspD/IspF Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Bifunctional enzyme IspD/IspF Lipid transport and metabolism Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (ispD), and converts 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP (ispF) ispDF None 6.7 41691.0 Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) GenBank Gene Database AL111168 GenBank Protein Database 112360903 UniProtKB Q9PM68 UniProt Accession ISPDF_CAMJE 2-C- methyl-D-erythritol 2,4-cyclodiphosphate synthase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;EC 2.7.7.60 4-diphosphocytidyl-2C- methyl-D-erythritol synthase EC 4.6.1.12 MCT MECDP-synthase MECPS MEP cytidylyltransferase >IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase MSEMSLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNITYM KKFTKNYEFIEGGDTRAESLKKALELIDSEFVMVSDVARVLVSKNLFDRLIENLDKADCI TPALKVADTTLFDNEALQREKIKLIQTPQISKTKLLKKALDQNLEFTDDSTAIAAMGGKI WFVEGEENARKLTFKEDLKKLDLPTPSFEIFTGNGFDVHEFGENRPLLLAGVQIHPTMGL KAHSDGDVLAHSLTDAILGAAGLGDIGELYPDTDMKFKNANSMELLKQAYDKVREIGFEL INIDICVMAQSPKLKDFKQAMQSNIAHTLDLDEFRINVKATTTEKLGFIGRKEGMAVLSS VNLKYFDWTRL >1116 bp ATGAGTGAAATGAGCCTCATTATGTTAGCAGCTGGAAATTCTACTCGTTTTAATACAAAG GTAAAAAAACAATTTTTACGACTTGGAAATGACCCTCTTTGGCTTTATGCAACAAAAAAT TTAAGCTCTTTTTATCCTTTTAAAAAAATAGTTGTTACCTCTAGTAATATCACTTATATG AAAAAATTTACCAAAAACTATGAATTCATAGAAGGTGGTGATACCAGAGCAGAATCCTTA AAAAAAGCCTTAGAGCTCATAGATAGCGAATTTGTTATGGTAAGTGATGTAGCAAGGGTA TTGGTGAGTAAAAATTTGTTTGATCGTTTGATTGAAAATTTAGATAAAGCAGATTGTATT ACCCCTGCTTTAAAAGTTGCAGATACAACACTTTTTGACAATGAAGCCTTGCAAAGAGAA AAAATCAAACTCATTCAAACCCCGCAAATTTCTAAAACCAAATTGCTTAAAAAAGCCTTG GATCAAAACCTAGAATTTACAGATGATAGCACAGCTATAGCTGCAATGGGTGGAAAAATT TGGTTTGTTGAAGGTGAAGAAAATGCAAGAAAACTAACCTTTAAAGAAGATCTTAAAAAA CTTGATTTGCCTACACCTAGCTTTGAAATTTTTACTGGCAATGGTTTTGATGTGCATGAA TTTGGAGAGAATCGCCCTTTGCTTTTAGCAGGAGTGCAAATTCATCCTACTATGGGGCTT AAAGCACACAGCGATGGAGATGTTTTAGCTCACTCTTTAACCGATGCGATTTTAGGTGCT GCAGGACTTGGAGATATAGGAGAGCTTTATCCTGATACTGATATGAAATTTAAAAATGCC AACTCCATGGAGCTTTTAAAACAAGCTTATGATAAAGTCAGAGAAATAGGTTTTGAACTC ATTAATATAGACATTTGCGTCATGGCACAAAGCCCTAAACTTAAAGACTTTAAACAAGCT ATGCAAAGCAATATAGCTCATACTTTAGATTTAGATGAATTTAGAATCAATGTTAAAGCC ACAACAACGGAAAAATTGGGTTTTATTGGAAGAAAAGAAGGTATGGCGGTGCTTAGTAGT GTAAATTTAAAATATTTTGATTGGACAAGATTATGA PF02542 YgbB PF01128 IspD function 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity function 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity function nucleotidyltransferase activity function phosphorus-oxygen lyase activity function catalytic activity function 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity function lyase activity function transferase activity function transferase activity, transferring phosphorus-containing groups process primary metabolism process lipid metabolism process cellular lipid metabolism process physiological process process isoprenoid metabolism process isoprenoid biosynthesis process metabolism process polyisoprenoid metabolism process terpenoid metabolism process terpenoid biosynthesis BE0004106 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Escherichia coli (strain K12) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid transport and metabolism Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP. Also converts 4-diphosphocytidyl-2-C-methyl-D- erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP ispF None 6.51 16897.4 Escherichia coli (strain K12) GeneCards ispF GenBank Gene Database L07942 GenBank Protein Database 433711 UniProtKB P62617 UniProt Accession ISPF_ECOLI MECDP-synthase MECPS >2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK >480 bp ATGCGAATTGGACACGGTTTTGACGTACATGCCTTTGGCGGTGAAGGCCCAATTATCATT GGTGGCGTACGCATTCCTTACGAAAAAGGATTGCTGGCGCATTCTGATGGCGACGTGGCG CTCCATGCGTTGACCGATGCATTGCTTGGCGCGGCGGCGCTGGGGGATATCGGCAAGCTG TTCCCGGATACCGATCCGGCATTTAAAGGTGCCGATAGCCGCGAGCTGCTACGCGAAGCC TGGCGTCGTATTCAGGCGAAGGGTTATACCCTTGGCAACGTCGATGTCACTATCATCGCT CAGGCACCGAAGATGTTGCCGCACATTCCACAAATGCGCGTGTTTATTGCCGAAGATCTC GGCTGCCATATGGATGATGTTAACGTGAAAGCCACTACTACGGAAAAACTGGGATTTACC GGACGTGGGGAAGGGATTGCCTGTGAAGCGGTGGCGCTACTCATTAAGGCAACAAAATGA PF02542 YgbB function catalytic activity function lyase activity function phosphorus-oxygen lyase activity function 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity process terpenoid biosynthesis process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism process polyisoprenoid metabolism process physiological process process terpenoid metabolism BE0000776 Farnesyl pyrophosphate synthase Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Farnesyl pyrophosphate synthase Coenzyme transport and metabolism Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate FDPS 1q22 Cytoplasm 202-219; 322-344 4.8 40533.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:3631 GenAtlas FDPS GeneCards FDPS GenBank Gene Database J05262 GenBank Protein Database 182399 UniProtKB P14324 UniProt Accession FPPS_HUMAN Farnesyl diphosphate synthetase FPP synthetase FPS >Farnesyl pyrophosphate synthetase MNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNR GLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQ KPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQ GNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQ IQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVAR VKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK >1062 bp ATGAACGGAGACCAGAATTCAGATGTTTATGCCCAAGAAAAGCAGGATTTCGTTCAGCAC TTCTCCCAGATCGTTAGGGTGCTGACTGAGGATGAGATGGGGCACCCAGAGATAGGAGAT GCTATTGCCCGGCTCAAGGAGGTCCTGGAGTACAATGCCATTGGAGGCAAGTATAACCGG GGTTTGACGGTGGTAGTAGCATTCCGGGAGCTGGTGGAGCCAAGGAAACAGGATGCTGAT AGTCTCCAGCGGGCCTGGACTGTGGGCTGGTGTGTGGAACTGCTGCAAGCTTTCTTCCTG GTGGCAGATGACATCATGGATTCATCCCTTACCCGCCGGGGACAGACCTGCTGGTATCAG AAGCCGGGCGTGGGTTTGGATGCCATCAATGATGCTAACCTCCTGGAAGCATGTATCTAC CGCCTGCTGAAGCTCTATTGCCGGGAGCAGCCCTATTACCTGAACCTGATCGAGCTCTTC CTGCAGAGTTCCTATCAGACTGAGATTGGGCAGACCCTGGACCTCCTCACAGCCCCCCAG GGCAATGTGGATCTTGTCAGATTCACTGAAAAGAGGTACAAATCTATTGTCAAGTACAAG ACAGCTTTCTACTCCTTCTACCTTCCTATAGCTGCAGCCATGTACATGGCAGGAATTGAT GGCGAGAAGGAGCACGCCAATGCCAAGAAGATCCTGCTGGAGATGGGGGAGTTCTTTCAG ATTCAGGATGATTACCTTGACCTCTTTGGGGACCCCAGTGTGACCGGCAAAATTGGCACT GACATCCAGGACAACAAATGCAGCTGGCTGGTGGTTCAGTGTCTGCAACGGGCCACTCCA GAACAGTACCAGATCCTGAAGGAAAATTACGGGCAGAAGGAGGCTGAGAAAGTGGCCCGG GTGAAGGCGCTATATGAGGAGCTGGATCTGCCAGCAGTGTTCTTGCAATATGAGGAAGAC AGTTACAGCCACATTATGGCTCTCATTGAACAGTACGCAGCACCCCTGCCCCCAGCCGTC TTTCTGGGGCTTGCGCGCAAAATCTACAAGCGGAGAAAGTGA PF00348 polyprenyl_synt process isoprenoid biosynthesis process physiological process process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism BE0004037 Prenyltransferase Streptomyces sp. (strain CL190) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Prenyltransferase Involved in transferase activity None 4.64 33744.0 Streptomyces sp. (strain CL190) GenBank Gene Database AB187169 GenBank Protein Database 67968193 UniProtKB Q4R2T2 UniProt Accession Q4R2T2_STRC1 >Prenyltransferase MSEAADVERVYAAMEEAAGLLGVACARDKIYPLLSTFQDTLVEGGSVVVFSMASGRHSTE LDFSISVPTSHGDPYATVVEKGLFPATGHPVDDLLADTQKHLPVSMFAIDGEVTGGFKKT YAFFPTDNMPGVAELSAIPSMPPAVAENAELFARYGLDKVQMTSMDYKKRQVNLYFSELS AQTLEAESVLALVRELGLHVPNELGLKFCKRSFSVYPTLNWETGKIDRLCFAVISNDPTL VPSSDEGDIEKFHNYATKAPYAYVGEKRTLVYGLTLSPKEEYYKLGAYYHITDVQRGLLK AFDSLED BE0003570 Geranylgeranyl pyrophosphate synthase Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Geranylgeranyl pyrophosphate synthase Coenzyme transport and metabolism Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins GGPS1 1q43 Cytoplasm None 6.06 34870.6 Human HUGO Gene Nomenclature Committee (HGNC) GNC:4249 GeneCards GGPS1 GenBank Gene Database AB017971 GenBank Protein Database 4520350 UniProtKB O95749 UniProt Accession GGPPS_HUMAN Dimethylallyltranstransferase Farnesyltranstransferase Geranylgeranyl diphosphate synthase Geranyltranstransferase GGPP synthetase GGPPSase >Geranylgeranyl pyrophosphate synthetase MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE PF00348 polyprenyl_synt process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism process isoprenoid biosynthesis process physiological process BE0004093 (2Z,6E)-farnesyl diphosphate synthase Mycobacterium tuberculosis # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown (2Z,6E)-farnesyl diphosphate synthase Lipid transport and metabolism Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall Rv1086 None 5.41 29410.0 Mycobacterium tuberculosis GenBank Gene Database BX842575 GenBank Protein Database 2078076 UniProtKB O53434 UniProt Accession ZFPP_MYCTU Z-FPP synthetase Z-FPPS Z-isoprenyl diphosphate synthase >Short-chain Z-isoprenyl diphosphate synthetase MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRM GAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSV RTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGA TAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA FRHVDFLRALRDYSARHRSYGR >1113 bp TTGAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTG TCCGCGTGTGGTAACGACGACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCG GCGAAGGTCGATTGCGGGGGGAAGAAGACACTCAAAGCCAGTGGGTCGACGGCGCAGGCC AACGCGATGACCCGCTTTGTCAACGTGTTCGAGCAGGCCTGCCCCGGCCAAACCCTGAAC TACACGGCCAATGGTTCGGGCGCTGGAATCAGCGAATTTAATGGCAACCAAACCGATTTC GGTGGCTCAGATGTACCCCTGAGCAAGGACGAGGCCGCAGCGGCGCAGCGGCGTTGCGGC TCGCCGGCGTGGAATCTGCCGGTGGTGTTCGGCCCGATCGCGGTTACCTACAACCTCAAC AGCGTTTCCTCGCTAAATTTGGACGGCCCCACGTTGGCGAAGATCTTCAACGGCTCCATT ACGCAGTGGAACAATCCCGCGATCCAGGCGCTGAACCGCGACTTCACGCTGCCAGGTGAG CGGATTCACGTGGTGTTCCGCAGCGATGAGTCGGGGACCACGGACAACTTCCAGAGGTAC CTGCAGGCCGCGTCCAACGGTGCGTGGGGTAAGGGCGCTGGAAAGTCGTTCCAAGGCGGC GTCGGTGAGGGCGCGCGGGGTAACGATGGCACGTCAGCGGCCGCGAAGAACACCCCGGGG TCGATCACCTACAACGAGTGGTCGTTCGCCCAGGCGCAGCACCTGACCATGGCCAACATC GTCACTTCGGCTGGTGGGGACCCGGTGGCGATTACTATCGACTCGGTCGGCCAGACGATC GCCGGGGCCACCATCTCCGGGGTGGGCAACGACCTGGTGCTCGACACGGACTCGTTCTAC CGGCCGAAGCGTCCCGGCTCCTATCCGATCGTGTTAGCGACATACGAAATCGTTTGCTCG AAGTATCCCGACTCGCAGGTTGGCACGGCTGTGAAGGCGTTCCTGCAGAGCACTATCGGC GCCGGTCAAAGCGGCCTGGGGGACAACGGATACATCCCAATTCCGGACGAGTTCAAATCG AGGCTGTCGACTGCGGTCAACGCGATCGCCTGA PF01255 Prenyltransf function transferase activity function catalytic activity process metabolism process physiological process BE0004107 Decaprenyl diphosphate synthase Mycobacterium tuberculosis # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Decaprenyl diphosphate synthase uppS Mycobacterium tuberculosis UniProtKB P60479 UniProt Accession DPDS_MYCTU "
owl:sameAs	drug:Zoledronate
owl:sameAs	drug:Iron
owl:sameAs	drug:Rosuvastatin
owl:sameAs	drug:Geranyl Diphosphate
owl:sameAs	drug:Lovastatin
owl:sameAs	drug:EXPT01640
rdf:type	drugbank:drugs
owl:sameAs	drug:Fluvastatin
owl:sameAs	drug:Pamidronate
owl:sameAs	drug:Cholesterol
owl:sameAs	drug:Pravastatin
owl:sameAs	drug:Risedronate
owl:sameAs	drug:Ibandronate
owl:sameAs	drug:Cholecalciferol

" experimental Oscar Alvizo, Robert McDaniel, Benjamin Mijts, "PRODUCTION OF GERANYL DIPHOSPHATE." U.S. Patent US20130011888, issued January 10, 2013. This compound belongs to the isoprenoid phosphates. These are prenol lipids containing a phosphate group linked to an isoprene unit. Isoprenoid Phosphates Organic Compounds Lipids Prenol Lipids Isoprenoid Phosphates Acyclic Monoterpenes Organic Pyrophosphates Organophosphate Esters Organic Phosphoric Acids Polyamines organic phosphate phosphoric acid ester polyamine logP 1.63 ALOGPS logS -2.5 ALOGPS Water Solubility 9.02e-01 g/l ALOGPS logP 1.96 ChemAxon IUPAC Name [({[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid ChemAxon Traditional IUPAC Name {[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy(hydroxy)phosphoryl}oxyphosphonic acid ChemAxon Molecular Weight 314.2091 ChemAxon Monoisotopic Weight 314.068426018 ChemAxon SMILES CC(C)=CCC\C(C)=C\CO[P@@](=O)(O)OP(=O)(O)O ChemAxon Molecular Formula C10H20O7P2 ChemAxon InChI InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+ ChemAxon InChIKey InChIKey=GVVPGTZRZFNKDS-JXMROGBWSA-N ChemAxon Polar Surface Area (PSA) 113.29 ChemAxon Refractivity 72.93 ChemAxon Polarizability 28.52 ChemAxon Rotatable Bond Count 8 ChemAxon H Bond Acceptor Count 5 ChemAxon H Bond Donor Count 3 ChemAxon pKa (strongest acidic) 1.77 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Ghose Filter true ChemAxon ChEBI 17211 PubChem Compound 445995 PubChem Substance 46504900 KEGG Compound C00341 ChemSpider 393471 PDB GPP SMP00319 Lysosomal Acid Lipase Deficiency (Wolman Disease) DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00510 Mevalonic aciduria DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00131 Atorvastatin Action Pathway DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00089 Pravastatin Action Pathway DB00169 Cholecalciferol DB00175 Pravastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00082 Simvastatin Action Pathway DB00169 Cholecalciferol DB00641 Simvastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00095 Alendronate Action Pathway DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00107 Zoledronate Action Pathway DB00169 Cholecalciferol DB00399 Zoledronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00112 Risedronate Action Pathway DB00169 Cholecalciferol DB00884 Risedronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00092 Rosuvastatin Action Pathway DB00169 Cholecalciferol DB01098 Rosuvastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00099 Lovastatin Action Pathway DB00169 Cholecalciferol DB00227 Lovastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00117 Pamidronate Action Pathway DB00169 Cholecalciferol DB00282 Pamidronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00079 Ibandronate Action Pathway DB00169 Cholecalciferol DB00710 Ibandronate DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P14324 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00119 Fluvastatin Action Pathway DB00169 Cholecalciferol DB01095 Fluvastatin DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00111 Cerivastatin Action Pathway DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol P04035 Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P35610 P38571 SMP00023 Steroid Biosynthesis DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00388 Chondrodysplasia Punctata II, X Linked Dominant (CDPX2) DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00387 CHILD Syndrome DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00508 Cholesteryl ester storage disease DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00386 Desmosterolosis DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00511 Wolman disease DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00509 Hyper-IgD syndrome DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00209 Hypercholesterolemia DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 SMP00389 Smith-Lemli-Opitz Syndrome (SLOS) DB00169 Cholecalciferol DB01592 Iron DB02552 Geranyl Diphosphate DB04540 Cholesterol Q9BWD1 Q01581 Q03426 Q15126 P53602 Q13907 P14324 O95749 P37268 Q14534 P48449 Q15392 Q16850 O76062 Q15800 Q15738 P56937 Q15125 O75845 P04035 P35610 P38571 BE0001303 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Shigella flexneri # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid transport and metabolism Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP ispF None 6.51 16898.0 Shigella flexneri GenBank Gene Database AE005674 GenBank Protein Database 24053164 UniProtKB P62619 UniProt Accession ISPF_SHIFL EC 4.6.1.12 MECDP-synthase MECPS >2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK >480 bp TCATTTTGTTGCCTTAATGAGTAGCGCCACCGCTTCACAGGCAATCCCTTCCCCACGTCC GGTAAATCCAAGTTTTTCCGTAGTAGTGGCTTTCACGTTAACATCATCCATATGGCAGCC GAGATCTTCGGCAATAAACACGCGCATTTGTGGAATGTGCGGCAACATCTTCGGTGCCTG AGCGATGATAGTGACATCGACGTTGCCAAGGGTATAACCCTTCGCCTGAATACGACGCCA GGCTTCGCGTAGCAGCTCGCGGCTGTCGGCACCTTTAAATGCCGGATCGGTATCCGGGAA CAGTTTGCCGATATCCCCCAGCGCCGCCGCGCCAAGCAATGCATCGGTCAACGCATGAAG CGCCACGTCGCCATCAGAATGCGCCAGCAATCCTTTTTCGTAAGGAATGCGTACGCCACC AATGATAATTGGGCCTTCACCGCCAAAGGCGTGTACGTCAAAACCGTGTCCAATTCGCAT PF02542 YgbB function lyase activity function phosphorus-oxygen lyase activity function 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity function catalytic activity process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism process polyisoprenoid metabolism process physiological process process terpenoid metabolism process terpenoid biosynthesis BE0001748 Bifunctional enzyme IspD/IspF Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Bifunctional enzyme IspD/IspF Lipid transport and metabolism Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (ispD), and converts 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP (ispF) ispDF None 6.7 41691.0 Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) GenBank Gene Database AL111168 GenBank Protein Database 112360903 UniProtKB Q9PM68 UniProt Accession ISPDF_CAMJE 2-C- methyl-D-erythritol 2,4-cyclodiphosphate synthase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;EC 2.7.7.60 4-diphosphocytidyl-2C- methyl-D-erythritol synthase EC 4.6.1.12 MCT MECDP-synthase MECPS MEP cytidylyltransferase >IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase MSEMSLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNITYM KKFTKNYEFIEGGDTRAESLKKALELIDSEFVMVSDVARVLVSKNLFDRLIENLDKADCI TPALKVADTTLFDNEALQREKIKLIQTPQISKTKLLKKALDQNLEFTDDSTAIAAMGGKI WFVEGEENARKLTFKEDLKKLDLPTPSFEIFTGNGFDVHEFGENRPLLLAGVQIHPTMGL KAHSDGDVLAHSLTDAILGAAGLGDIGELYPDTDMKFKNANSMELLKQAYDKVREIGFEL INIDICVMAQSPKLKDFKQAMQSNIAHTLDLDEFRINVKATTTEKLGFIGRKEGMAVLSS VNLKYFDWTRL >1116 bp ATGAGTGAAATGAGCCTCATTATGTTAGCAGCTGGAAATTCTACTCGTTTTAATACAAAG GTAAAAAAACAATTTTTACGACTTGGAAATGACCCTCTTTGGCTTTATGCAACAAAAAAT TTAAGCTCTTTTTATCCTTTTAAAAAAATAGTTGTTACCTCTAGTAATATCACTTATATG AAAAAATTTACCAAAAACTATGAATTCATAGAAGGTGGTGATACCAGAGCAGAATCCTTA AAAAAAGCCTTAGAGCTCATAGATAGCGAATTTGTTATGGTAAGTGATGTAGCAAGGGTA TTGGTGAGTAAAAATTTGTTTGATCGTTTGATTGAAAATTTAGATAAAGCAGATTGTATT ACCCCTGCTTTAAAAGTTGCAGATACAACACTTTTTGACAATGAAGCCTTGCAAAGAGAA AAAATCAAACTCATTCAAACCCCGCAAATTTCTAAAACCAAATTGCTTAAAAAAGCCTTG GATCAAAACCTAGAATTTACAGATGATAGCACAGCTATAGCTGCAATGGGTGGAAAAATT TGGTTTGTTGAAGGTGAAGAAAATGCAAGAAAACTAACCTTTAAAGAAGATCTTAAAAAA CTTGATTTGCCTACACCTAGCTTTGAAATTTTTACTGGCAATGGTTTTGATGTGCATGAA TTTGGAGAGAATCGCCCTTTGCTTTTAGCAGGAGTGCAAATTCATCCTACTATGGGGCTT AAAGCACACAGCGATGGAGATGTTTTAGCTCACTCTTTAACCGATGCGATTTTAGGTGCT GCAGGACTTGGAGATATAGGAGAGCTTTATCCTGATACTGATATGAAATTTAAAAATGCC AACTCCATGGAGCTTTTAAAACAAGCTTATGATAAAGTCAGAGAAATAGGTTTTGAACTC ATTAATATAGACATTTGCGTCATGGCACAAAGCCCTAAACTTAAAGACTTTAAACAAGCT ATGCAAAGCAATATAGCTCATACTTTAGATTTAGATGAATTTAGAATCAATGTTAAAGCC ACAACAACGGAAAAATTGGGTTTTATTGGAAGAAAAGAAGGTATGGCGGTGCTTAGTAGT GTAAATTTAAAATATTTTGATTGGACAAGATTATGA PF02542 YgbB PF01128 IspD function 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity function 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity function nucleotidyltransferase activity function phosphorus-oxygen lyase activity function catalytic activity function 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity function lyase activity function transferase activity function transferase activity, transferring phosphorus-containing groups process primary metabolism process lipid metabolism process cellular lipid metabolism process physiological process process isoprenoid metabolism process isoprenoid biosynthesis process metabolism process polyisoprenoid metabolism process terpenoid metabolism process terpenoid biosynthesis BE0004106 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Escherichia coli (strain K12) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid transport and metabolism Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP. Also converts 4-diphosphocytidyl-2-C-methyl-D- erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP ispF None 6.51 16897.4 Escherichia coli (strain K12) GeneCards ispF GenBank Gene Database L07942 GenBank Protein Database 433711 UniProtKB P62617 UniProt Accession ISPF_ECOLI MECDP-synthase MECPS >2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK >480 bp ATGCGAATTGGACACGGTTTTGACGTACATGCCTTTGGCGGTGAAGGCCCAATTATCATT GGTGGCGTACGCATTCCTTACGAAAAAGGATTGCTGGCGCATTCTGATGGCGACGTGGCG CTCCATGCGTTGACCGATGCATTGCTTGGCGCGGCGGCGCTGGGGGATATCGGCAAGCTG TTCCCGGATACCGATCCGGCATTTAAAGGTGCCGATAGCCGCGAGCTGCTACGCGAAGCC TGGCGTCGTATTCAGGCGAAGGGTTATACCCTTGGCAACGTCGATGTCACTATCATCGCT CAGGCACCGAAGATGTTGCCGCACATTCCACAAATGCGCGTGTTTATTGCCGAAGATCTC GGCTGCCATATGGATGATGTTAACGTGAAAGCCACTACTACGGAAAAACTGGGATTTACC GGACGTGGGGAAGGGATTGCCTGTGAAGCGGTGGCGCTACTCATTAAGGCAACAAAATGA PF02542 YgbB function catalytic activity function lyase activity function phosphorus-oxygen lyase activity function 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity process terpenoid biosynthesis process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism process polyisoprenoid metabolism process physiological process process terpenoid metabolism BE0000776 Farnesyl pyrophosphate synthase Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Farnesyl pyrophosphate synthase Coenzyme transport and metabolism Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate FDPS 1q22 Cytoplasm 202-219; 322-344 4.8 40533.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:3631 GenAtlas FDPS GeneCards FDPS GenBank Gene Database J05262 GenBank Protein Database 182399 UniProtKB P14324 UniProt Accession FPPS_HUMAN Farnesyl diphosphate synthetase FPP synthetase FPS >Farnesyl pyrophosphate synthetase MNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNR GLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQ KPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQ GNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQ IQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVAR VKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK >1062 bp ATGAACGGAGACCAGAATTCAGATGTTTATGCCCAAGAAAAGCAGGATTTCGTTCAGCAC TTCTCCCAGATCGTTAGGGTGCTGACTGAGGATGAGATGGGGCACCCAGAGATAGGAGAT GCTATTGCCCGGCTCAAGGAGGTCCTGGAGTACAATGCCATTGGAGGCAAGTATAACCGG GGTTTGACGGTGGTAGTAGCATTCCGGGAGCTGGTGGAGCCAAGGAAACAGGATGCTGAT AGTCTCCAGCGGGCCTGGACTGTGGGCTGGTGTGTGGAACTGCTGCAAGCTTTCTTCCTG GTGGCAGATGACATCATGGATTCATCCCTTACCCGCCGGGGACAGACCTGCTGGTATCAG AAGCCGGGCGTGGGTTTGGATGCCATCAATGATGCTAACCTCCTGGAAGCATGTATCTAC CGCCTGCTGAAGCTCTATTGCCGGGAGCAGCCCTATTACCTGAACCTGATCGAGCTCTTC CTGCAGAGTTCCTATCAGACTGAGATTGGGCAGACCCTGGACCTCCTCACAGCCCCCCAG GGCAATGTGGATCTTGTCAGATTCACTGAAAAGAGGTACAAATCTATTGTCAAGTACAAG ACAGCTTTCTACTCCTTCTACCTTCCTATAGCTGCAGCCATGTACATGGCAGGAATTGAT GGCGAGAAGGAGCACGCCAATGCCAAGAAGATCCTGCTGGAGATGGGGGAGTTCTTTCAG ATTCAGGATGATTACCTTGACCTCTTTGGGGACCCCAGTGTGACCGGCAAAATTGGCACT GACATCCAGGACAACAAATGCAGCTGGCTGGTGGTTCAGTGTCTGCAACGGGCCACTCCA GAACAGTACCAGATCCTGAAGGAAAATTACGGGCAGAAGGAGGCTGAGAAAGTGGCCCGG GTGAAGGCGCTATATGAGGAGCTGGATCTGCCAGCAGTGTTCTTGCAATATGAGGAAGAC AGTTACAGCCACATTATGGCTCTCATTGAACAGTACGCAGCACCCCTGCCCCCAGCCGTC TTTCTGGGGCTTGCGCGCAAAATCTACAAGCGGAGAAAGTGA PF00348 polyprenyl_synt process isoprenoid biosynthesis process physiological process process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism BE0004037 Prenyltransferase Streptomyces sp. (strain CL190) # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Prenyltransferase Involved in transferase activity None 4.64 33744.0 Streptomyces sp. (strain CL190) GenBank Gene Database AB187169 GenBank Protein Database 67968193 UniProtKB Q4R2T2 UniProt Accession Q4R2T2_STRC1 >Prenyltransferase MSEAADVERVYAAMEEAAGLLGVACARDKIYPLLSTFQDTLVEGGSVVVFSMASGRHSTE LDFSISVPTSHGDPYATVVEKGLFPATGHPVDDLLADTQKHLPVSMFAIDGEVTGGFKKT YAFFPTDNMPGVAELSAIPSMPPAVAENAELFARYGLDKVQMTSMDYKKRQVNLYFSELS AQTLEAESVLALVRELGLHVPNELGLKFCKRSFSVYPTLNWETGKIDRLCFAVISNDPTL VPSSDEGDIEKFHNYATKAPYAYVGEKRTLVYGLTLSPKEEYYKLGAYYHITDVQRGLLK AFDSLED BE0003570 Geranylgeranyl pyrophosphate synthase Human # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Geranylgeranyl pyrophosphate synthase Coenzyme transport and metabolism Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins GGPS1 1q43 Cytoplasm None 6.06 34870.6 Human HUGO Gene Nomenclature Committee (HGNC) GNC:4249 GeneCards GGPS1 GenBank Gene Database AB017971 GenBank Protein Database 4520350 UniProtKB O95749 UniProt Accession GGPPS_HUMAN Dimethylallyltranstransferase Farnesyltranstransferase Geranylgeranyl diphosphate synthase Geranyltranstransferase GGPP synthetase GGPPSase >Geranylgeranyl pyrophosphate synthetase MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE PF00348 polyprenyl_synt process metabolism process primary metabolism process lipid metabolism process cellular lipid metabolism process isoprenoid metabolism process isoprenoid biosynthesis process physiological process BE0004093 (2Z,6E)-farnesyl diphosphate synthase Mycobacterium tuberculosis # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown (2Z,6E)-farnesyl diphosphate synthase Lipid transport and metabolism Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall Rv1086 None 5.41 29410.0 Mycobacterium tuberculosis GenBank Gene Database BX842575 GenBank Protein Database 2078076 UniProtKB O53434 UniProt Accession ZFPP_MYCTU Z-FPP synthetase Z-FPPS Z-isoprenyl diphosphate synthase >Short-chain Z-isoprenyl diphosphate synthetase MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRM GAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSV RTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGA TAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA FRHVDFLRALRDYSARHRSYGR >1113 bp TTGAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTG TCCGCGTGTGGTAACGACGACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCG GCGAAGGTCGATTGCGGGGGGAAGAAGACACTCAAAGCCAGTGGGTCGACGGCGCAGGCC AACGCGATGACCCGCTTTGTCAACGTGTTCGAGCAGGCCTGCCCCGGCCAAACCCTGAAC TACACGGCCAATGGTTCGGGCGCTGGAATCAGCGAATTTAATGGCAACCAAACCGATTTC GGTGGCTCAGATGTACCCCTGAGCAAGGACGAGGCCGCAGCGGCGCAGCGGCGTTGCGGC TCGCCGGCGTGGAATCTGCCGGTGGTGTTCGGCCCGATCGCGGTTACCTACAACCTCAAC AGCGTTTCCTCGCTAAATTTGGACGGCCCCACGTTGGCGAAGATCTTCAACGGCTCCATT ACGCAGTGGAACAATCCCGCGATCCAGGCGCTGAACCGCGACTTCACGCTGCCAGGTGAG CGGATTCACGTGGTGTTCCGCAGCGATGAGTCGGGGACCACGGACAACTTCCAGAGGTAC CTGCAGGCCGCGTCCAACGGTGCGTGGGGTAAGGGCGCTGGAAAGTCGTTCCAAGGCGGC GTCGGTGAGGGCGCGCGGGGTAACGATGGCACGTCAGCGGCCGCGAAGAACACCCCGGGG TCGATCACCTACAACGAGTGGTCGTTCGCCCAGGCGCAGCACCTGACCATGGCCAACATC GTCACTTCGGCTGGTGGGGACCCGGTGGCGATTACTATCGACTCGGTCGGCCAGACGATC GCCGGGGCCACCATCTCCGGGGTGGGCAACGACCTGGTGCTCGACACGGACTCGTTCTAC CGGCCGAAGCGTCCCGGCTCCTATCCGATCGTGTTAGCGACATACGAAATCGTTTGCTCG AAGTATCCCGACTCGCAGGTTGGCACGGCTGTGAAGGCGTTCCTGCAGAGCACTATCGGC GCCGGTCAAAGCGGCCTGGGGGACAACGGATACATCCCAATTCCGGACGAGTTCAAATCG AGGCTGTCGACTGCGGTCAACGCGATCGCCTGA PF01255 Prenyltransf function transferase activity function catalytic activity process metabolism process physiological process BE0004107 Decaprenyl diphosphate synthase Mycobacterium tuberculosis # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Decaprenyl diphosphate synthase uppS Mycobacterium tuberculosis UniProtKB P60479 UniProt Accession DPDS_MYCTU "

owl:sameAs

drug:Iron

owl:sameAs

drug:Geranyl Diphosphate

Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB02552"

Context graph