Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB02310"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium"
|
| rdf:type | |
| drugbank:description |
"
experimental
This compound belongs to the phenanthrolines. These are aromatic polycyclic compounds containing the phenanthroline skeleton, which is a derivative of phenanthrene, and consists of two pyridine rings non-linearly joined by a benzene ring.
Phenanthrolines
Organic Compounds
Heterocyclic Compounds
Phenanthrolines
Quinolines and Derivatives
Toluenes
Pyridinium Derivatives
Polyamines
quinoline
toluene
pyridine
pyridinium
benzene
polyamine
amine
organonitrogen compound
logP
-1.6
ALOGPS
logS
-6.1
ALOGPS
Water Solubility
2.05e-04 g/l
ALOGPS
logP
0.042
ChemAxon
IUPAC Name
1,3,5,6,8-pentamethyl-1,10-phenanthrolin-1-ium
ChemAxon
Traditional IUPAC Name
1,3,5,6,8-pentamethyl-1,10-phenanthrolin-1-ium
ChemAxon
Molecular Weight
251.3462
ChemAxon
Monoisotopic Weight
251.154823618
ChemAxon
SMILES
CC1=CN=C2C(=C1)C(C)=C(C)C1=C2[N+](C)=CC(C)=C1
ChemAxon
Molecular Formula
C17H19N2
ChemAxon
InChI
InChI=1S/C17H19N2/c1-10-6-14-12(3)13(4)15-7-11(2)9-19(5)17(15)16(14)18-8-10/h6-9H,1-5H3/q+1
ChemAxon
InChIKey
InChIKey=FQTUZNACZKILMC-UHFFFAOYSA-N
ChemAxon
Polar Surface Area (PSA)
16.77
ChemAxon
Refractivity
80.47
ChemAxon
Polarizability
30.34
ChemAxon
Rotatable Bond Count
0
ChemAxon
H Bond Acceptor Count
1
ChemAxon
H Bond Donor Count
0
ChemAxon
pKa (strongest basic)
3.53
ChemAxon
Physiological Charge
1
ChemAxon
Number of Rings
3
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
Ghose Filter
true
ChemAxon
PubChem Compound
168131
PubChem Substance
46508662
ChemSpider
147071
PDB
TNP
BE0001534
Methionine aminopeptidase 2
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Methionine aminopeptidase 2
Translation, ribosomal structure and biogenesis
Removes the amino-terminal methionine from nascent proteins
METAP2
12q22
Cytoplasmic
None
5.57
52892.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:16672
GenAtlas
METAP2
GeneCards
METAP2
GenBank Gene Database
U29607
GenBank Protein Database
903982
UniProtKB
P50579
UniProt Accession
MAP2_HUMAN
EC 3.4.11.18
Initiation factor 2-associated 67 kDa glycoprotein
MetAP 2
p67
p67eIF2
Peptidase M 2
>Methionine aminopeptidase 2
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
>1437 bp
ATGGCGGGCGTGGAGGAGGTAGCGGCCTCCGGGAGCCACCTGAATGGCGACCTGGATCCA
GACGACAGGGAAGAAGGAGCTGCCTCTACGGCTGAGGAAGCAGCCAAGAAAAAAAGACGA
AAGAAGAAGAAGAGCAAAGGGCCTTCTGCAGCAGGGGAACAGGAACCTGATAAAGAATCA
GGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTGGAAGATAAAGAA
AGAGATGAAGATGATGAAGATGGAGATGGCGATGGAGATGGAGCAACTGGAAAGAAGAAG
AAAAAGAAGAAGAAGAAGAGAGGACCAAAAGTTCAAACAGACCCTCCCTCAGTTCCAATA
TGTGACCTGTATCCTAATGGTGTATTTCCCAAAGGACAAGAATGCGAATACCCACCCACA
CAAGATGGGCGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGATCAG
GCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCAGAAGCACATCGACAAGTTAGA
AAATACGTAATGAGCTGGATCAAGCCTGGGATGACAATGATAGAAATCTGTGAAAAGTTG
GAAGACTGTTCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTTCCT
ACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACTCCCAATGCCGGTGACACAACA
GTATTACAGTATGATGACATCTGTAAAATAGACTTTGGAACACATATAAGTGGTAGGATT
ATTGACTGTGCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTATTAAAAGCTGTA
AAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATTGATGTTCGTCTGTGTGATGTT
GGTGAGGCCATCCAAGAAGTTATGGAGTCCTATGAAGTTGAAATAGATGGGAAGACATAT
CAAGTGAAACCAATCCGTAATCTAAATGGACATTCAATTGGGCAATATAGAATACATGCT
GGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACAAGAATGGAGGAAGGAGAAGTA
TATGCAATTGAAACCTTTGGTAGTACAGGAAAAGGTGTTGTTCATGATGATATGGAATGT
TCACATTACATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTTCCAAGAACAAAA
CACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTTGCCTTCTGCCGCAGATGGCTG
GATCGCTTGGGAGAAAGTAAATACTTGATGGCTCTGAAGAATCTGTGTGACTTGGGCATT
GTAGATCCATATCCACCATTATGTGACATTAAAGGATCATATACAGCGCAATTTGAACAT
ACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGCAGAGGAGATGACTATTAA
PF00557
Peptidase_M24
function
methionyl aminopeptidase activity
function
hydrolase activity
function
peptidase activity
function
metallopeptidase activity
function
exopeptidase activity
function
metalloexopeptidase activity
function
catalytic activity
function
aminopeptidase activity
process
metabolism
process
macromolecule metabolism
process
protein metabolism
process
cellular protein metabolism
process
proteolysis
process
physiological process
"
|
| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object