Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB02262"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"Orotic Acid"
|
| rdf:type | |
| drugbank:description |
"
65-86-1
experimental
Paul Rambacher, Siegfried Make, "Process for preparing orotic acid." U.S. Patent US4062847, issued November, 1960.
This compound belongs to the pyrimidinecarboxylic acids. These are pyrimidines whose structure contain a carboxyl group attached to the pyrimidine ring.
Pyrimidinecarboxylic Acids
Organic Compounds
Heterocyclic Compounds
Diazines
Pyrimidines and Pyrimidine Derivatives
Hydropyrimidine Carboxylic Acids and Derivatives
Pyrimidones
Polyamines
Enolates
Carboxylic Acids
pyrimidone
hydropyrimidine
carboxylic acid derivative
enolate
polyamine
carboxylic acid
organonitrogen compound
logP
-0.89
ALOGPS
logS
-1.5
ALOGPS
Water Solubility
4.51e+00 g/l
ALOGPS
logP
-1.2
ChemAxon
IUPAC Name
2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
ChemAxon
Traditional IUPAC Name
orotic acid
ChemAxon
Molecular Weight
156.0963
ChemAxon
Monoisotopic Weight
156.017106626
ChemAxon
SMILES
OC(=O)C1=CC(=O)NC(=O)N1
ChemAxon
Molecular Formula
C5H4N2O4
ChemAxon
InChI
InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
ChemAxon
InChIKey
InChIKey=PXQPEWDEAKTCGB-UHFFFAOYSA-N
ChemAxon
Polar Surface Area (PSA)
95.5
ChemAxon
Refractivity
33.27
ChemAxon
Polarizability
12.46
ChemAxon
Rotatable Bond Count
1
ChemAxon
H Bond Acceptor Count
4
ChemAxon
H Bond Donor Count
3
ChemAxon
pKa (strongest acidic)
2.83
ChemAxon
pKa (strongest basic)
-6
ChemAxon
Physiological Charge
-1
ChemAxon
Number of Rings
1
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
Water Solubility
1820 mg/L (at 18 °C)
YALKOWSKY,SH & DANNENFELSER,RM (1992)
Melting Point
345.5 °C
PhysProp
logP
-0.83
SANGSTER (1994)
logS
-1.93
ADME Research, USCD
ChEBI
16742
PubChem Compound
967
PubChem Substance
46508903
KEGG Compound
C00295
KEGG Drug
D00055
PDB
ORO
BE0002008
Dihydroorotate dehydrogenase A (fumarate)
Lactococcus lactis subsp. cremoris
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Dihydroorotate dehydrogenase A (fumarate)
Nucleotide transport and metabolism
(S)-dihydroorotate + O(2) = orotate + H(2)O(2)
pyrDA
Cytoplasm
None
4.84
34211.0
Lactococcus lactis subsp. cremoris
GenBank Gene Database
AY323899
GenBank Protein Database
33302311
UniProtKB
Q53ZE5
UniProt Accession
PYRDA_LACLC
DHOD A
DHODase A
DHOdehase A
Dihydroorotate oxidase A
EC 1.3.3.1
>Dihydroorotate dehydrogenase A
MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAYITKSSTLEKREGNPLPRYVD
LELGSINSMGLPNLGFDYYLDYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDF
SGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKPLGVKLPPYFDLVHFDIMAEI
LNQFPLTYVNSVNSIGNGLFIDPEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLK
PEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPAIFDRIIKELEEIMNQKGYQS
IADFHGKLKSL
>936 bp
ATGCTTAATACAACTTTTGCAAATGCCAAATTCGCTAATCCATTTATGAACGCTTCAGGA
GTCCATTGTATGACGATTGAGGATTTAGAAGAATTAAAAGCCTCTCAAGCAGGGGCCTAT
ATCACCAAAAGTTCCACATTAGAAAAAAGAGAAGGTAATCCACTCCCACGTTATGTTGAC
TTAGAATTAGGGTCAATTAATTCTATGGGTCTGCCTAATTTAGGATTTGATTACTACTTA
GACTATGTTTTAAAAAATCAAAAAGAAAATGCTCAAGAAGGGCCAATCTTCTTTTCCATT
GCGGGTATGAGTGCAGCAGAAAATATCGCTATGCTCAAGAAAATTCAAGAAAGTGATTTT
TCAGGAATTACAGAGTTGAATCTTTCTTGTCCAAATGTTCCTGGTAAACCACAACTTGCT
TATGATTTTGAAGCAACTGAAAAGCTCCTAAAAGAAGTTTTTACTTTCTTTACAAAACCG
CTAGGTGTCAAACTTCCCCCTTATTTTGACCTTGTACATTTTGATATTATGGCAGAAATC
CTCAATCAGTTTCCATTGACTTATGTGAATTCAGTGAATAGTATTGGAAATGGACTTTTT
ATTGACCCAGAAGCAGAAAGCGTAGTTATTAAGCCTAAAGATGGATTTGGTGGAATTGGT
GGAGCTTACATCAAACCAACAGCGCTTGCAAATGTCCGTGCTTTCTATACTCGACTCAAA
CCTGAAATTCAAATCATTGGAACAGGTGGGATTGAAACAGGACAAGATGCCTTTGAACAC
CTCTTATGTGGAGCTACAATGCTTCAAATTGGAACAGCTTTACACAAAGAAGGACCTGCA
ATCTTTGATAGAATCATTAAAGAATTAGAAGAAATAATGAATCAAAAAGGCTATCAATCA
ATTGCTGATTTCCATGGAAAATTAAAATCATTATAA
PF01180
DHO_dh
component
cell
component
intracellular
component
cytoplasm
function
oxidoreductase activity, acting on the CH-CH group of donors
function
oxidoreductase activity
function
dihydroorotate dehydrogenase activity
function
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
function
dihydroorotate oxidase activity
function
catalytic activity
process
pyrimidine nucleoside monophosphate biosynthesis
process
metabolism
process
nucleobase metabolism
process
cellular metabolism
process
pyrimidine base metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
pyrimidine base biosynthesis
process
nucleotide metabolism
process
'de novo' pyrimidine base biosynthesis
process
pyrimidine nucleotide metabolism
process
pyrimidine ribonucleoside monophosphate biosynthesis
process
physiological process
process
pyrimidine nucleotide biosynthesis
process
UMP biosynthesis
BE0001533
Orotate phosphoribosyltransferase
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Orotate phosphoribosyltransferase
Nucleotide transport and metabolism
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
pyrE
None
5.68
23562.0
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
GenBank Gene Database
Z19547
GenBank Protein Database
47812
UniProtKB
P08870
UniProt Accession
PYRE_SALTY
EC 2.4.2.10
OPRT
OPRTase
>Orotate phosphoribosyltransferase
MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDS
GIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRKEAKDHGEGGSLVGSALQGRV
MLVDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQERGRGEISAIQEVERDYGCKVIS
IITLKDLIAYLEEKPDMAEHLAAVRAYREEFGV
>642 bp
ATGAAACCGTATCAGCGCCAGTTTATTGAGTTTGCGCTTAACAAGCAGGTACTAAAGTTT
GGCGAGTTTACGCTGAAATCCGGGCGCAAAAGCCCCTATTTCTTCAACGCCGGGCTGTTT
AATACCGGGCGCGACCTGGCGTTGTTAGGCCGTTTTTATGCCGAAGCGCTGGTGGATTCC
GGTATTGAATTTGATCTGCTGTTTGGCCCCGCGTACAAAGGTATTCCGATCGCGACGACG
ACGGCGGTTGCGCTGGCGGAACATCACGATAAAGACCTGCCGTACTGCTTTAACCGCAAA
GAGGCAAAAGATCATGGTGAAGGCGGGAGCCTGGTGGGCAGCGCGCTACAGGGCCGCGTG
ATGCTGGTGGATGACGTGATTACCGCAGGTACGGCGATTCGCGAGTCAATGGAGATTATT
CAGGCGCACGGGGCTACGCTGGCTGGCGTACTGATTTCGCTGGATCGTCAGGAACGTGGC
CGCGGCGAGATTTCCGCGATTCAGGAAGTGGAGCGCGACTATGGTTGTAAGGTTATCTCC
ATCATTACGCTGAAAGACCTGATTGCCTATCTGGAAGAAAAACCTGATATGGCTGAGCAT
CTGGCGGCTGTGCGAGCATACCGGGAAGAATTTGGCGTGTAA
PF00156
Pribosyltran
function
transferase activity
function
transferase activity, transferring glycosyl groups
function
transferase activity, transferring pentosyl groups
function
catalytic activity
function
orotate phosphoribosyltransferase activity
process
metabolism
process
cellular metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleotide metabolism
process
pyrimidine nucleotide metabolism
process
pyrimidine nucleotide biosynthesis
process
physiological process
process
nucleoside metabolism
BE0000382
Dihydroorotate dehydrogenase (quinone), mitochondrial
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Dihydroorotate dehydrogenase (quinone), mitochondrial
Nucleotide transport and metabolism
DHODH
16q22
Mitochondrion; mitochondrial inner membrane
13-32
10.23
42868.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2867
GenAtlas
DHODH
GeneCards
DHODH
GenBank Gene Database
M94065
GenBank Protein Database
555594
UniProtKB
Q02127
UniProt Accession
PYRD_HUMAN
DHOdehase
Dihydroorotate dehydrogenase, mitochondrial precursor
Dihydroorotate oxidase
EC 1.3.3.1
>Dihydroorotate dehydrogenase, mitochondrial precursor
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
>1191 bp
AAATTACCGTGGAGACACCTGCAAAAGCGGGCCCAGGATGCTGTGATCATCCTGGGGGGA
GGAGGACTTCTCTTCGCCTCCTACCTGATGGCCACGGGAGATGAGCGTTTCTATGCTGAA
CACCTGATGCCGACTCTGCAGGGGCTGCTGGACCCGGAGTCAGCCCACAGACTGGCTGTT
CGCTTCACCTCCCTGGGGCTCCTTCCACGGGCCAGATTTCAAGACTCTGACATGCTGGAA
GTGAGAGTTCTGGGCCATAAATTCCGAAATCCAGTAGGAATTGCTGCAGGATTTGACAAG
CATGGGGAAGCCGTGGACGGACTTTATAAGATGGGCTTTGGTTTTGTTGAGATAGGAAGT
GTGACTCCAAAACCTCAGGAAGGAAACCCTAGACCCAGAGTCTTCCGCCTCCCTGAGGAC
CAAGCTGTCATTAACAGGTATGGATTTAACAGTCACGGGCTTTCAGTGGTGGAACACAGG
TTACGGGCCAGACAGCAGAAGCAGGCCAAGCTCACAGAAGATGGACTGCCTCTGGGGGTC
AACTTGGGGAAGAACAAGACCTCAGTGGACGCCGCGGAGGACTACGCAGAAGGGGTGCGC
GTACTGGGCCCCCTGGCCGACTACCTGGTGGTGAATGTGTCCAGCCCCAACACTGCCGGG
CTGCGGAGCCTTCAGGGAAAGGCCGAGCTGCGCCGCCTGCTGACCAAGGTGCTGCAGGAG
AGGGATGGCTTGCGGAGAGTGCACAGGCCGGCAGTCCTGGTGAAGATCGCTCCTGACCTC
ACCAGCCAGGATAAGGAGGACATTGCCAGTGTGGTCAAAGAGTTGGGCATCGATGGGCTG
ATTGTTACGAACACCACCGTGAGTCGCCCTGCGGGCCTCCAGGGTGCCCTGCGCTCTGAA
ACAGGAGGGCTGAGTGGGAAGCCCCTCCGGGATTTATCAACTCAAACCATTCGGGAGATG
TATGCACTCACCCAAGGCCGAGTTCCCATAATTGGGGTTGGTGGTGTGAGCAGCGGGCAG
GACGCGCTGGAGAAGATCCGGGCAGGGGCCTCCCTGGTGCAGCTGTACACGGCCCTCACC
TTCTGGGGGCCACCCGTTGTGGGCAAAGTCAAGCGGGAACTGGAGGCCCTTCTGAAAGAG
CAGGGCTTTGGCGGAGTCACAGATGCCATTGGAGCAGATCATCGGAGGTGA
PF01180
DHO_dh
component
membrane
component
cell
function
catalytic activity
function
oxidoreductase activity, acting on the CH-CH group of donors
function
dihydroorotate dehydrogenase activity
function
oxidoreductase activity
function
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
function
dihydroorotate oxidase activity
process
pyrimidine base metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
pyrimidine base biosynthesis
process
nucleotide metabolism
process
'de novo' pyrimidine base biosynthesis
process
pyrimidine nucleotide metabolism
process
pyrimidine ribonucleoside monophosphate biosynthesis
process
pyrimidine nucleotide biosynthesis
process
UMP biosynthesis
process
physiological process
process
pyrimidine nucleoside monophosphate biosynthesis
process
nucleobase metabolism
process
metabolism
process
cellular metabolism
BE0001525
Dihydroorotate dehydrogenase (quinone)
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Dihydroorotate dehydrogenase (quinone)
Nucleotide transport and metabolism
(S)-dihydroorotate + O(2) = orotate + H(2)O(2)
pyrD
Cell membrane; peripheral membrane protein
None
7.97
36775.0
Escherichia coli (strain K12)
GenBank Gene Database
X02826
GenBank Protein Database
42609
UniProtKB
P0A7E1
UniProt Accession
PYRD_ECOLI
DHOD
DHODase
DHOdehase
Dihydroorotate oxidase
EC 1.3.3.1
>Dihydroorotate dehydrogenase
MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL
AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV
DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG
LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID
GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS
VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
>1011 bp
ATGTACTACCCCTTCGTTCGTAAAGCCCTTTTCCAGCTCGATCCAGAGCGCGCTCATGAG
TTTACTTTTCAGCAATTACGCCGTATTACAGGAACGCCGTTTGAAGCACTGGTGCGGCAG
AAAGTGCCTGCGAAACCTGTTAACTGCATGGGCCTGACGTTTAAAAATCCGCTTGGTCTG
GCAGCCGGTCTTGATAAAGACGGGGAGTGCATTGACGCGTTAGGCGCGATGGGATTTGGA
TCGATCGAGATCGGTACCGTCACGCCACGTCCACAGCCAGGTAATGACAAGCCGCGTCTC
TTTCGTCTGGTAGATGCCGAAGGTTTGATCAACCGTATGGGCTTTAATAATCTTGGCGTT
GATAACCTCGTAGAGAACGTAAAAAAGGCCCATTATGACGGCGTCCTGGGTATTAACATC
GGCAAAAATAAAGATACGCCAGTGGAGCAGGGCAAAGATGACTATCTGATTTGTATGGAA
AAAATCTATGCCTATGCGGGATATATCGCCATCAATATTTCATCGCCGAATACCCCAGGA
TTACGCACGCTGCAATATGGTGAAGCGCTGGATGATCTCTTAACCGCGATTAAAAATAAG
CAAAATGATTTGCAAGCGATGCACCATAAATATGTGCCGATCGCAGTGAAGATCGCGCCG
GATCTTTCTGAAGAAGAATTGATCCAGGTTGCCGATAGTTTAGTTCGCCATAATATTGAT
GGCGTTATTGCAACCAATACCACACTCGATCGTTCTCTTGTTCAGGGAATGAAAAATTGC
GATCAAACCGGTGGCTTAAGTGGTCGTCCGCTTCAGTTAAAAAGCACCGAAATTATTCGC
CGCTTGTCACTGGAATTAAACGGTCGCTTACCGATCATCGGTGTTGGCGGCATCGACTCG
GTTATCGCTGCGCGTGAAAAGATTGCTGCGGGTGCCTCACTGGTGCAAATTTATTCTGGT
TTTATTTTTAAAGGTCCGCCGCTGATTAAAGAAATCGTTACCCATATCTAA
PF01180
DHO_dh
component
cell
component
membrane
function
dihydroorotate oxidase activity
function
catalytic activity
function
oxidoreductase activity, acting on the CH-CH group of donors
function
dihydroorotate dehydrogenase activity
function
oxidoreductase activity
function
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
process
pyrimidine base metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
pyrimidine base biosynthesis
process
nucleotide metabolism
process
'de novo' pyrimidine base biosynthesis
process
pyrimidine nucleotide metabolism
process
pyrimidine ribonucleoside monophosphate biosynthesis
process
pyrimidine nucleotide biosynthesis
process
UMP biosynthesis
process
physiological process
process
pyrimidine nucleoside monophosphate biosynthesis
process
nucleobase metabolism
process
metabolism
process
cellular metabolism
BE0001452
Dihydroorotase
Escherichia coli (strain K12)
inhibitor
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11752352
unknown
Dihydroorotase
Nucleotide transport and metabolism
(S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate
pyrC
Cytoplasmic
None
6.14
38828.0
Escherichia coli (strain K12)
GenBank Gene Database
X04469
GenBank Protein Database
42607
UniProtKB
P05020
UniProt Accession
PYRC_ECOLI
DHOase
EC 3.5.2.3
>Dihydroorotase
MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYR
QRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSI
DAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHIT
TKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVA
SGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNG
PQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ
>1047 bp
ATGACTGCACCATCCCAGGTATTAAAGATCCGCCGCCCAGACGACTGGCACCTTCACCTC
CGCGATGGCGACATGTTAAAAACTGTCGTGCCATATACCAGCGAAATTTATGGACGGGCT
ATCGTAATGCCCAATCTGGCTCCGCCCGTGACCACCGTTGAGGCTGCCGTGGCGTATCGC
CAGCGTATTCTTGACGCCGTACCTGCCGGGCACGATTTCACCCCATTGATGACCTGTTAT
TTAACAGATTCGCTGGATCCTAATGAGCTGGAGCGCGGATTTAACGAAGGCGTGTTCACC
GCTGCAAAACTTTACCCGGCAAACGCAACCACTAACTCCAGCCACGGCGTGACGTCAATT
GACGCAATCATGCCGGTACTTGAGCGCATGGAAAAAATCGGTATGCCGCTACTGGTGCAT
GGTGAAGTGACACATGCAGATATCGACATTTTTGATCGTGAAGCGCGCTTTATAGAAAGC
GTGATGGAACCTCTGCGCCAGCGCCTGACTGCGCTGAAAGTCGTTTTTGAGCACATCACC
ACCAAAGATGCTGCCGACTATGTCCGTGACGGAAATGAACGGCTGGCTGCCACCATCACT
CCGCAGCATCTGATGTTTAACCGCAACCATATGCTGGTTGGAGGCGTGCGTCCGCACCTG
TATTGTCTACCCATCCTCAAACGTAATATTCACCAACAGGCATTGCGTGAACTGGTCGCC
AGCGGTTTTAATCGAGTATTCCTCGGTACGGATTCTGCGCCACATGCACGTCATCGCAAA
GAGAGCAGTTGCGGCTGCGCGGGCTGCTTCAACGCCCCAACCGCGCTGGGCAGTTACGCT
ACCGTCTTTGAAGAAATGAATGCTTTGCAGCACTTTGAAGCATTCTGTTCTGTAAACGGC
CCGCAGTTCTATGGGTTGCCGGTCAACGACACATTCATCGAACTGGTACGTGAAGAGCAA
CAGGTTGCTGAAAGCATCGCACTGACTGATGACACGCTGGTGCCATTCCTCGCCGGGGAA
ACGGTACGCTGGTCCGTTAAACAATAA
PF01979
Amidohydro_1
function
hydrolase activity
function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
function
dihydroorotase activity
function
catalytic activity
process
metabolism
process
cellular metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
nucleobase metabolism
process
pyrimidine base metabolism
process
pyrimidine base biosynthesis
process
physiological process
"
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| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object