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PredicateValue (sorted: none)
drugbank:description
" experimental This compound belongs to the pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group. Pyrimidine Nucleotide Sugars Organic Compounds Organooxygen Compounds Carbohydrates and Carbohydrate Conjugates Glycosyl Compounds Pyrimidine Ribonucleoside Diphosphates Mixed Pentose/Hexose Disaccharides N-acyl-alpha-hexosamines Disaccharide Phosphates Organic Pyrophosphates Pyrimidones Organic Phosphoric Acids Hydropyrimidines Oxanes Organophosphate Esters Tetrahydrofurans Oxolanes Secondary Carboxylic Acid Amides Secondary Alcohols 1,2-Diols Primary Alcohols Enolates Polyamines Carboxylic Acids Ethers mixed pentose/hexose disaccharide n-acyl-alpha-hexosamine disaccharide phosphate glucosamine disaccharide amino sugar organic pyrophosphate pyrimidone organic phosphate phosphoric acid ester oxane hydropyrimidine pyrimidine tetrahydrofuran oxolane 1,2-diol secondary alcohol secondary carboxylic acid amide carboxamide group primary alcohol carboxylic acid carboxylic acid derivative ether polyamine enolate alcohol amine organonitrogen compound logP -1.4 ALOGPS logS -1.7 ALOGPS Water Solubility 1.14e+01 g/l ALOGPS logP -5.3 ChemAxon IUPAC Name [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid ChemAxon Traditional IUPAC Name {[(2R,3S,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphinic acid ChemAxon Molecular Weight 607.3537 ChemAxon Monoisotopic Weight 607.081569477 ChemAxon SMILES CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[P@](O)(=O)O[P@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O ChemAxon Molecular Formula C17H27N3O17P2 ChemAxon InChI InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11+,12-,13-,14-,15-,16-/m1/s1 ChemAxon InChIKey InChIKey=LFTYTUAZOPRMMI-NESSUJCYSA-N ChemAxon Polar Surface Area (PSA) 300.41 ChemAxon Refractivity 117.56 ChemAxon Polarizability 51.05 ChemAxon Rotatable Bond Count 10 ChemAxon H Bond Acceptor Count 14 ChemAxon H Bond Donor Count 9 ChemAxon pKa (strongest acidic) 1.74 ChemAxon pKa (strongest basic) -3.5 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 3 ChemAxon Bioavailability 0 ChemAxon MDDR-Like Rule true ChemAxon PubChem Compound 23700 PubChem Substance 46508676 PDB UD2 BE0004629 Exostosin-like 2 Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Exostosin-like 2 EXTL2 Human UniProtKB Q9UBQ6 UniProt Accession EXTL2_HUMAN BE0001429 UDP-N-acetylhexosamine pyrophosphorylase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-N-acetylhexosamine pyrophosphorylase Involved in nucleotidyltransferase activity Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P UAP1 1q23.3 Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the None 6.29 58770.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:12457 GenAtlas UAP1 GeneCards UAP1 GenBank Gene Database S73498 GenBank Protein Database 7717462 UniProtKB Q16222 UniProt Accession UAP1_HUMAN AGX AGX-1 Antigen X EC 2.7.7.- EC 2.7.7.23 Sperm- associated antigen 2 UDP-N-acetylglucosamine pyrophosphorylase >UDP-N-acetylhexosamine pyrophosphorylase MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSS HQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAY PKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTK HKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDME QRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPY VDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTT ARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQ CEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI >1518 bp ATGAACATTAATGACCTCAAACTCACGTTGTCCAAAGCTGGGCAAGAGCACCTACTACGT TTCTGGAATGAGCTTGAAGAAGCCCAACAGGTAGAACTTTATGCAGAGCTCCAGGCCATG AACTTTGAGGAGCTGAACTTCTTTTTCCAAAAGGCCATTGAAGGTTTTAACCAGTCTTCT CACCAAAAGAATGTGGATGCACGAATGGAACCTGTGCCTCGAGAGGTATTAGGCAGTGCT ACAAGGGATCAAGATCAGCTCCAGGCCTGGGAAAGTGAAGGACTTTTCCAGATTTCTCAG AATAAAGTAGCAGTTCTTCTTCTAGCTGGTGGGCAGGGGACAAGACTCGGCGTTGCATAT CCTAAGGGGATGTATGATGTTGGTTTGCCATCCCGTAAGACACTTTTTCAGATTCAAGCA GAGCGTATCCTGAAGCTACAGCAGGTTGCTGAAAAATATTATGGCAACAAATGCATTATT CCATGGTATATAATGACCAGTGGCAGAACAATGGAATCTACAAAGGAGTTCTTCACCAAG CACAAGTACTTTGGTTTAAAAAAAGAGAATGTAATCTTTTTTCAGCAAGGAATGCTCCCC GCCATGAGTTTTGATGGGAAAATTATTTTGGAAGAGAAGAACAAAGTTTCTATGGCTCCA GATGGGAATGGTGGTCTTTATCGGGCACTTGCAGCCCAGAATATTGTGGAGGATATGGAG CAAAGAGGCATTTGGAGCATTCATGTCTATTGTGTTGACAACATATTAGTAAAAGTGGCA GACCCACGGTTCATTGGATTTTGCATTCAGAAAGGAGCAGACTGTGGAGCAAAGGTGGTA GAGAAAACGAACCCTACAGAACCAGTTGGAGTGGTTTGCCGAGTGGATGGAGTTTACCAG GTGGTAGAATATAGTGAGATTTCCCTGGCAACAGCTCAAAAACGAAGCTCAGACGGACGA CTGCTGTTCAATGCGGGGAACATTGCCAACCATTTCTTCACTGTACCATTTCTGAGAGAT GTTGTCAATGTTTATGAACCTCAGTTGCAGCACCATGTGGCTCAAAAGAAGATTCCTTAT GTGGATACCCAAGGACAGTTAATTAAGCCAGACAAACCCAATGGAATAAAGATGGAAAAA TTTGTCTTTGACATCTTCCAGTTTGCAAAGAAGTTTGTGGTATATGAAGTATTGCGAGAA GATGAGTTTTCCCCACTAAAGAATGCTGATAGTCAGAATGGGAAAGACAACCCTACTACT GCAAGGCATGCTTTGATGTCCCTTCATCATTGCTGGGTCCTCAATGCAGGGGGCCATTTC ATAGATGAAAATAGCTCTCGCCTTCCAGCAATTCCCCGCTTGAAGGATGCCAATGATGTA CCAATCCAATGTGAAATCTCTCCTCTTATCTCCTATGCTGGAGAAGGATTAGAAAGTTAT GTGGCAGATAAAGAATTCCATGCACCTCTAATCATCGATGAGAATGGAGTTCATGAGCTG GTGAAAAATGGTATTTGA PF01704 UDPGP function nucleotidyltransferase activity function catalytic activity function transferase activity function transferase activity, transferring phosphorus-containing groups process physiological process process metabolism BE0001521 UDP-glucose 4-epimerase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-glucose 4-epimerase Cell wall/membrane/envelope biogenesis Catalyzes two distinct but analogous reactions:the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine GALE 1p36-p35 None 6.71 38282.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:4116 GenAtlas GALE GeneCards GALE GenBank Gene Database L41668 GenBank Protein Database 1119217 UniProtKB Q14376 UniProt Accession GALE_HUMAN EC 5.1.3.2 Galactowaldenase UDP-galactose 4-epimerase >UDP-glucose 4-epimerase MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA >1047 bp ATGGCAGAGAAGGTGCTGGTAACAGGTGGGGCTGGCTACATTGGCAGCCACACGGTGCTG GAGCTGCTGGAGGCTGGCTACTTGCCTGTGGTCATCGATAACTTCCATAATGCCTTCCGT GGAGGGGGCTCCCTGCCTGAGAGCCTGCGGCGGGTCCAGGAGCTGACAGGCCGCTCTGTG GAGTTTGAGGAGATGGACATTTTGGACCAGGGAGCCCTACAGCGTCTCTTCAAAAAGTAC AGCTTTATGGCGGTCATCCACTTTGCGGGGCTCAAGGCCGTGGGCGAGTCGGTGCAGAAG CCTCTGGATTATTACAGAGTTAACCTGACCGGGACCATCCAGCTTCTGGAGATCATGAAG GCCCACGGGGTGAAGAACCTGGTGTTCAGCAGCTCAGCCACTGTGTACGGGAACCCCCAG TACCTGCCCCTTGATGAGGCCCACCCCACGGGTGGTTGTACCAACCCTTACGGCAAGTCC AAGTTCTTCATCGAGGAAATGATCCGGGACCTGTGCCAGGCAGACAAGACTTGGAACGTA GTGCTGCTGCGCTATTTCAACCCCACAGGTGCCCATGCCTCTGGCTGCATTGGTGAGGAT CCCCAGGGCATACCCAACAACCTCATGCCTTATGTCTCCCAGGTGGCGATCGGGCGACGG GAGGCCCTGAATGTCTTTGGCAATGACTATGACACAGAGGATGGCACAGGTGTCCGGGAT TACATCCATGTCGTGGATCTGGCCAAGGGCCACATTGCAGCCTTAAGGAAGCTGAAAGAA CAGTGTGGCTGCCGGATCTACAACCTGGGCACGGGCACAGGCTATTCAGTGCTGCAGATG GTCCAGGCTATGGAGAAGGCCTCTGGGAAGAAGATCCCGTACAAGGTGGTGGCACGGCGG GAAGGTGATGTGGCAGCCTGTTACGCCAACCCCAGCCTGGCCCAAGAGGAGCTGGGGTGG ACAGCAGCCTTAGGGCTGGACAGGATGTGTGAGGATCTCTGGCGCTGGCAGAAGCAGAAT CCTTCAGGCTTTGGCACGCAAGCCTGA PF01370 Epimerase function catalytic activity function NAD binding function racemase and epimerase activity function cofactor binding function racemase and epimerase activity, acting on carbohydrates and derivatives function coenzyme binding function UDP-glucose 4-epimerase activity function isomerase activity function binding process hexose metabolism process metabolism process cellular metabolism process nucleotide-sugar metabolism process macromolecule metabolism process galactose metabolism process carbohydrate metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process alcohol metabolism process physiological process process monosaccharide metabolism BE0001428 UDP-N-acetylglucosamine 2-epimerase Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-N-acetylglucosamine 2-epimerase Cell wall/membrane/envelope biogenesis Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption wecB Cytoplasm None 6.32 42245.0 Escherichia coli (strain K12) GenBank Gene Database M87049 GenBank Protein Database 148189 UniProtKB P27828 UniProt Accession WECB_ECOLI Bacteriophage N4 adsorption protein C EC 5.1.3.14 UDP-GlcNAc-2- epimerase >UDP-N-acetylglucosamine 2-epimerase MKVLTVFGTRPEAIKMAPLVHALAKDPFFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNI MQPGQGLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGL RTGDLYSPWPEEANRTLTGHLAMYHFSPTETSRQNLLRENVADSRIFITGNTVIDALLWV RDQVMSSDKLRSELAANYPFIDPDKKMILVTGHRRESFGRGFEEICHALADIATTHQDIQ IVYPVHLNPNVREPVNRILGHVKNVILIDPQEYLPFVWLMNHAWLILTDSGGIQEEAPSL GKPVLVMRDTTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAMSRAHNPYGDGQ ACSRILEALKNNRISL >1131 bp GTGAAAGTACTGACTGTATTTGGTACGCGCCCGGAAGCCATCAAGATGGCGCCGTTGGTG CATGCGTTGGCAAAAGATCCTTTTTTTGAGGCTAAAGTTTGCGTCACTGCGCAGCATCGG GAGATGCTCGATCAGGTGCTGAAACTCTTTTCCATTGTACCTGACTACGATCTCAACATA ATGCAGCCAGGACAGGGCCTGACAGAGATAACCTGTCGGATTCTGGAAGGGCTAAAACCT ATTCTTGCCGAGTTCAAACCAGACGTCGTGCTGGTTCACGGCGATACGACGACGACGCTG GCAACCAGCCTGGCGGCGTTTTATCAGCGTATTCCTGTTGGTCACGTTGAGGCTGGTCTG CGCACGGGCGATCTCTATTCGCCGTGGCCGGAAGAGGCTAACCGTACATTGACCGGGCAT CTGGCGATGTATCACTTCTCTCCAACCGAAACTTCCCGGCAAAACTTGCTGCGTGAAAAC GTTGCGGATAGCCGAATCTTCATTACCGGTAATACAGTCATTGATGCACTGTTATGGGTG CGTGACCAGGTGATGAGCAGCGACAAGCTGCGTTCAGAACTGGCGGCAAATTACCCGTTT ATCGACCCCGATAAAAAGATGATTCTGGTGACCGGTCACAGGCGTGAGAGTTTCGGTCGT GGCTTTGAAGAAATCTGCCACGCGCTGGCAGACATCGCCACCACGCACCAGGACATCCAG ATTGTCTATCCGGTGCATCTCAACCCGAACGTCAGAGAACCGGTCAATCGCATTCTGGGG CATGTGAAAAATGTCATTCTGATCGATCCCCAGGAGTATTTACCGTTTGTCTGGCTGATG AACCACGCCTGGCTGATTTTGACCGACTCAGGCGGCATTCAGGAAGAAGCGCCTTCGCTG GGGAAACCTGTGCTGGTGATGCGCGATACCACTGAGCGTCCGGAAGCGGTGACGGCGGGT ACGGTGCGTCTGGTAGGCACGGATAAGCAGCGAATTGTCGAGGAAGTGACGCGTCTTTTA AAAGACGAAAACGAATATCAAGCTATGAGCCGCGCCCATAACCCGTATGGTGATGGTCAG GCATGCTCTCGCATTCTGGAAGCGTTAAAAAATAATCGGATATCACTATGA PF02350 Epimerase_2 function racemase and epimerase activity function catalytic activity function racemase and epimerase activity, acting on carbohydrates and derivatives function UDP-N-acetylglucosamine 2-epimerase activity function isomerase activity process nitrogen compound metabolism process UDP-N-acetylglucosamine metabolism process amine metabolism process amino sugar metabolism process glucosamine metabolism process physiological process process N-acetylglucosamine metabolism process metabolism process carbohydrate biosynthesis process macromolecule metabolism process macromolecule biosynthesis process polysaccharide biosynthesis process lipopolysaccharide biosynthesis BE0000214 Histo-blood group ABO system transferase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Histo-blood group ABO system transferase Involved in transferase activity, transferring hexosyl groups This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens:A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity ABO 9q34.1-q34.2 Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Membrane-b 33-53 9.24 40934.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:79 GenAtlas ABO GeneCards ABO GenBank Gene Database J05175 GenBank Protein Database 340078 UniProtKB P16442 UniProt Accession BGAT_HUMAN A transferase) EC 2.4.1.37 EC 2.4.1.40 Fucosylglycoprotein 3-alpha- galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha- galactosyltransferase Histo-blood group A transferase Histo-blood group B transferase NAGAT >Histo-blood group ABO system transferase MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDH LQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTV FAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKR WQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSS REAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVW HDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP >1062 bp ATGGCCGAGGTGTTGCGGACGCTGGCCGGAAAACCAAAATGCCACGCACTTCGACCTATG ATCCTTTTCCTAATAATGCTTGTCTTGGTCTTGTTTGGTTACGGGGTCCTAAGCCCCAGA AGTCTAATGCCAGGAAGCCTGGAACGGGGGTTCTGCATGGCTGTTAGGGAACCTGACCAT CTGCAGCGCGTCTCGTTGCCAAGGATGGTCTACCCCCAGCCAAAGGTGCTGACACCGTGG AAGGATGTCCTCGTGGTGACCCCTTGGCTGGCTCCCATTGTCTGGGAGGGCACATTCAAC ATCGACATCCTCAACGAGCAGTTCAGGCTCCAGAACACCACCATTGGGTTAACTGTGTTT GCCATCAAGAAATACGTGGCTTTCCTGAAGCTGTTCCTGGAGACGGCGGAGAAGCACTTC ATGGTGGGCCACCGTGTCCACTACTATGTCTTCACCGACCAGCTGGCCGCGGTGCCCCGC GTGACGCTGGGGACCGGTCGGCAGCTGTCAGTGCTGGAGGTGCGCGCCTACAAGCGCTGG CAGGACGTGTCCATGCGCCGCATGGAGATGATCAGTGACTTCTGCGAGCGGCGCTTCCTC AGCGAGGTGGATTACCTGGTGTGCGTGGACGTGGACATGGAGTTCCGCGACCACGTGGGC GTGGAGATCCTGACTCCGCTGTTCGGCACCCTGCACCCCGGCTTCTACGGAAGCAGCCGG GAGGCCTTCACCTACGAGCGCCGGCCCCAGTCCCAGGCCTACATCCCCAAGGACGAGGGC GATTTCTACTACCTGGGGGGGTTCTTCGGGGGGTCGGTGCAAGAGGTGCAGCGGCTCACC AGGGCCTGCCACCAGGCCATGATGGTCGACCAGGCCAACGGCATCGAGGCCGTGTGGCAC GACGAGAGCCACCTGAACAAGTACCTGCTGCGCCACAAACCCACCAAGGTGCTCTCCCCC GAGTACTTGTGGGACCAGCAGCTGCTGGGCTGGCCCGCCGTCCTGAGGAAGCTGAGGTTC ACTGCGGTGCCCAAGAACCACCAGGCGGTCCGGAACCCGTGA PF03414 Glyco_transf_6 component cell component membrane function transferase activity, transferring glycosyl groups function transferase activity, transferring hexosyl groups function catalytic activity function transferase activity process carbohydrate metabolism process physiological process process metabolism process macromolecule metabolism BE0001454 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Escherichia coli (strain K12) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Cell wall/membrane/envelope biogenesis Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG Cell inner membrane; peripheral membrane protein None 10.32 37815.0 Escherichia coli (strain K12) GenBank Gene Database X52644 GenBank Protein Database 809684 UniProtKB P17443 UniProt Accession MURG_ECOLI EC 2.4.1.227 pentapeptide Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase >UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFI RISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIP VVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGRE GPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKV TEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGA AKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRVARA >1068 bp ATGAGTGGTCAAGGAAAGCGATTAATGGTGATGGCAGGCGGAACCGGTGGACATGTATTC CCGGGACTGGCGGTTGCGCACCATCTAATGGCTCAGGGTTGGCAAGTTCGCTGGCTGGGG ACTGCCGACCGTATGGAAGCGGACTTAGTGCCAAAACATGGCATCGAAATTGATTTCATT CGTATCTCTGGTCTGCGTGGAAAAGGTATAAAAGCACTGATAGCTGCCCCGCTGCGTATC TTCAACGCCTGGCGTCAGGCGCGGGCGATTATGAAAGCGTACAAACCTGACGTGGTGCTC GGTATGGGAGGCTACGTGTCAGGTCCAGGTGGTCTGGCCGCGTGGTCGTTAGGCATTCCG GTTGTACTTCATGAACAAAACGGTATTGCGGGCTTAACCAATAAATGGCTGGCGAAGATT GCCACCAAAGTGATGCAGGCGTTTCCAGGTGCTTTCCCTAATGCGGAAGTAGTGGGTAAC CCGGTGCGTACCGATGTGTTGGCGCTGCCGTTGCCGCAGCAACGTTTGGCTGGACGTGAA GGTCCGGTTCGTGTGCTGGTAGTGGGTGGTTCTCAGGGCGCACGCATTCTTAACCAGACA ATGCCGCAGGTTGCTGCGAAACTGGGTGATTCAGTCACTATCTGGCATCAGAGCGGCAAA GGTTCGCAACAATCCGTTGAACAGGCGTATGCCGAAGCGGGGCAACCGCAGCATAAAGTG ACGGAATTTATTGATGATATGGCGGCGGCGTATGCGTGGGCGGATGTCGTCGTTTGCCGC TCCGGTGCGTTAACGGTGAGTGAAATCGCCGCGGCAGGACTACCGGCGTTGTTTGTGCCG TTTCAACATAAAGACCGCCAGCAATACTGGAATGCGCTACCGCTGGAAAAAGCGGGCGCA GCCAAAATTATCGAGCAGCCACAGCTTAGCGTGGATGCTGTCGCCAACACCCTGGCCGGG TGGTCGCGAGAAACCTTATTAACCATGGCAGAACGCGCCCGCGCTGCATCCATTCCGGAT GCCACCGAGCGAGTGGCAAATGAAGTGAGCCGGGTTGCCCGGGCGTAA PF04101 Glyco_tran_28_C PF03033 Glyco_transf_28 component membrane component organelle membrane component organelle inner membrane component cell function undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity function catalytic activity function transferase activity function transferase activity, transferring glycosyl groups function transferase activity, transferring hexosyl groups function carbohydrate binding function UDP-glycosyltransferase activity function binding function acetylglucosaminyltransferase activity process lipid modification process metabolism process lipid glycosylation process macromolecule metabolism process nitrogen compound metabolism process biopolymer metabolism process amine metabolism process biopolymer modification process amino sugar metabolism process UDP-N-acetylgalactosamine metabolism process UDP-N-acetylgalactosamine biosynthesis process carbohydrate metabolism process physiological process BE0002630 WbpP Pseudomonas aeruginosa unknown WbpP Involved in catalytic activity None 6.37 37749.0 Pseudomonas aeruginosa GenBank Gene Database AF498417 UniProtKB Q8KN66 UniProt Accession Q8KN66_PSEAI >WbpP MMSRYEELRKELPAQPKVWLITGVAGFIGSNLLETLLKLDQKVVGLDNFATGHQRNLDEV RSLVSEKQWSNFKFIQGDIRNLDDCNNACAGVDYVLHQAALGSVPRSINDPITSNATNID GFLNMLIAARDAKVQSFTYAASSSTYGDHPGLPKVEDTIGKPLSPYAVTKYVNELYADVF SRCYGFSTIGLRYFNVFGRRQDPNGAYAAVIPKWTSSMIQGDDVYINGDGETSRDFCYIE NTVQANLLAATAGLDARNQVYNIAVGGRTSLNQLFFALRDGLAENGVSYHREPVYRDFRE GDVRHSLADISKAAKLLGYAPKYDVSAGVALAMPWYIMFLK >1026 bp ATGATGAGTCGTTATGAAGAGCTAAGAAAGGAATTGCCGGCGCAGCCGAAAGTCTGGCTG ATTACAGGTGTGGCGGGCTTTATTGGCTCTAATCTTCTTGAGACTTTGCTAAAGCTTGAT CAGAAGGTTGTCGGTCTGGATAATTTTGCTACTGGTCATCAGCGGAACCTGGACGAAGTG CGGTCCTTGGTTAGCGAGAAGCAATGGTCAAATTTTAAATTTATTCAAGGTGATATTCGC AATCTGGATGATTGCAATAACGCCTGTGCAGGTGTTGATTACGTTTTACATCAAGCTGCC TTGGGTTCGGTACCGCGTTCTATTAACGATCCGATCACCTCCAATGCAACGAACATCGAT GGTTTCTTGAATATGCTGATTGCAGCCAGAGATGCCAAGGTGCAGAGTTTCACTTATGCG GCAAGTAGCTCTACCTATGGAGATCATCCTGGTTTACCGAAGGTGGAGGATACTATAGGT AAGCCTCTTTCCCCTTATGCGGTTACCAAATATGTGAATGAGCTTTATGCCGATGTGTTT TCACGCTGCTACGGCTTTTCGACCATTGGGCTTCGTTATTTCAATGTGTTCGGTCGTCGA CAGGATCCCAATGGTGCCTATGCGGCAGTCATACCAAAATGGACCTCTTCGATGATCCAG GGTGATGACGTCTATATTAACGGTGATGGCGAGACCAGTCGGGATTTTTGTTATATTGAA AACACCGTTCAGGCCAATCTGCTTGCTGCAACCGCGGGGCTTGATGCTCGTAATCAAGTT TACAATATTGCTGTTGGCGGGCGGACGAGTTTGAATCAGTTGTTCTTTGCGCTTCGCGAC GGCCTTGCCGAAAACGGTGTGTCCTATCACCGGGAACCTGTTTATCGTGATTTTAGGGAG GGGGATGTACGTCACTCTCTCGCTGATATCAGCAAGGCTGCCAAACTGCTGGGGTATGCG CCGAAATATGATGTGTCTGCAGGTGTGGCGTTGGCCATGCCTTGGTACATCATGTTTTTG AAATGA PF01370 Epimerase function cofactor binding function coenzyme binding function isomerase activity function binding function NAD binding function catalytic activity function racemase and epimerase activity function racemase and epimerase activity, acting on carbohydrates and derivatives process carbohydrate metabolism process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process physiological process process nucleotide-sugar metabolism process metabolism process cellular metabolism process macromolecule metabolism "
owl:sameAs
rdf:type
rdfs:label
"Uridine-Diphosphate-N-Acetylgalactosamine"

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

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