Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB02196"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"Uridine-Diphosphate-N-Acetylgalactosamine"
|
| rdf:type | |
| drugbank:description |
"
experimental
This compound belongs to the pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group.
Pyrimidine Nucleotide Sugars
Organic Compounds
Organooxygen Compounds
Carbohydrates and Carbohydrate Conjugates
Glycosyl Compounds
Pyrimidine Ribonucleoside Diphosphates
Mixed Pentose/Hexose Disaccharides
N-acyl-alpha-hexosamines
Disaccharide Phosphates
Organic Pyrophosphates
Pyrimidones
Organic Phosphoric Acids
Hydropyrimidines
Oxanes
Organophosphate Esters
Tetrahydrofurans
Oxolanes
Secondary Carboxylic Acid Amides
Secondary Alcohols
1,2-Diols
Primary Alcohols
Enolates
Polyamines
Carboxylic Acids
Ethers
mixed pentose/hexose disaccharide
n-acyl-alpha-hexosamine
disaccharide phosphate
glucosamine
disaccharide
amino sugar
organic pyrophosphate
pyrimidone
organic phosphate
phosphoric acid ester
oxane
hydropyrimidine
pyrimidine
tetrahydrofuran
oxolane
1,2-diol
secondary alcohol
secondary carboxylic acid amide
carboxamide group
primary alcohol
carboxylic acid
carboxylic acid derivative
ether
polyamine
enolate
alcohol
amine
organonitrogen compound
logP
-1.4
ALOGPS
logS
-1.7
ALOGPS
Water Solubility
1.14e+01 g/l
ALOGPS
logP
-5.3
ChemAxon
IUPAC Name
[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid
ChemAxon
Traditional IUPAC Name
{[(2R,3S,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphosphinic acid
ChemAxon
Molecular Weight
607.3537
ChemAxon
Monoisotopic Weight
607.081569477
ChemAxon
SMILES
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[P@](O)(=O)O[P@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O
ChemAxon
Molecular Formula
C17H27N3O17P2
ChemAxon
InChI
InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11+,12-,13-,14-,15-,16-/m1/s1
ChemAxon
InChIKey
InChIKey=LFTYTUAZOPRMMI-NESSUJCYSA-N
ChemAxon
Polar Surface Area (PSA)
300.41
ChemAxon
Refractivity
117.56
ChemAxon
Polarizability
51.05
ChemAxon
Rotatable Bond Count
10
ChemAxon
H Bond Acceptor Count
14
ChemAxon
H Bond Donor Count
9
ChemAxon
pKa (strongest acidic)
1.74
ChemAxon
pKa (strongest basic)
-3.5
ChemAxon
Physiological Charge
-2
ChemAxon
Number of Rings
3
ChemAxon
Bioavailability
0
ChemAxon
MDDR-Like Rule
true
ChemAxon
PubChem Compound
23700
PubChem Substance
46508676
PDB
UD2
BE0004629
Exostosin-like 2
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
# Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235
unknown
Exostosin-like 2
EXTL2
Human
UniProtKB
Q9UBQ6
UniProt Accession
EXTL2_HUMAN
BE0001429
UDP-N-acetylhexosamine pyrophosphorylase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-N-acetylhexosamine pyrophosphorylase
Involved in nucleotidyltransferase activity
Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P
UAP1
1q23.3
Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the
None
6.29
58770.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12457
GenAtlas
UAP1
GeneCards
UAP1
GenBank Gene Database
S73498
GenBank Protein Database
7717462
UniProtKB
Q16222
UniProt Accession
UAP1_HUMAN
AGX
AGX-1
Antigen X
EC 2.7.7.-
EC 2.7.7.23
Sperm- associated antigen 2
UDP-N-acetylglucosamine pyrophosphorylase
>UDP-N-acetylhexosamine pyrophosphorylase
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSS
HQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAY
PKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTK
HKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDME
QRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ
VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPY
VDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTT
ARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQ
CEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
>1518 bp
ATGAACATTAATGACCTCAAACTCACGTTGTCCAAAGCTGGGCAAGAGCACCTACTACGT
TTCTGGAATGAGCTTGAAGAAGCCCAACAGGTAGAACTTTATGCAGAGCTCCAGGCCATG
AACTTTGAGGAGCTGAACTTCTTTTTCCAAAAGGCCATTGAAGGTTTTAACCAGTCTTCT
CACCAAAAGAATGTGGATGCACGAATGGAACCTGTGCCTCGAGAGGTATTAGGCAGTGCT
ACAAGGGATCAAGATCAGCTCCAGGCCTGGGAAAGTGAAGGACTTTTCCAGATTTCTCAG
AATAAAGTAGCAGTTCTTCTTCTAGCTGGTGGGCAGGGGACAAGACTCGGCGTTGCATAT
CCTAAGGGGATGTATGATGTTGGTTTGCCATCCCGTAAGACACTTTTTCAGATTCAAGCA
GAGCGTATCCTGAAGCTACAGCAGGTTGCTGAAAAATATTATGGCAACAAATGCATTATT
CCATGGTATATAATGACCAGTGGCAGAACAATGGAATCTACAAAGGAGTTCTTCACCAAG
CACAAGTACTTTGGTTTAAAAAAAGAGAATGTAATCTTTTTTCAGCAAGGAATGCTCCCC
GCCATGAGTTTTGATGGGAAAATTATTTTGGAAGAGAAGAACAAAGTTTCTATGGCTCCA
GATGGGAATGGTGGTCTTTATCGGGCACTTGCAGCCCAGAATATTGTGGAGGATATGGAG
CAAAGAGGCATTTGGAGCATTCATGTCTATTGTGTTGACAACATATTAGTAAAAGTGGCA
GACCCACGGTTCATTGGATTTTGCATTCAGAAAGGAGCAGACTGTGGAGCAAAGGTGGTA
GAGAAAACGAACCCTACAGAACCAGTTGGAGTGGTTTGCCGAGTGGATGGAGTTTACCAG
GTGGTAGAATATAGTGAGATTTCCCTGGCAACAGCTCAAAAACGAAGCTCAGACGGACGA
CTGCTGTTCAATGCGGGGAACATTGCCAACCATTTCTTCACTGTACCATTTCTGAGAGAT
GTTGTCAATGTTTATGAACCTCAGTTGCAGCACCATGTGGCTCAAAAGAAGATTCCTTAT
GTGGATACCCAAGGACAGTTAATTAAGCCAGACAAACCCAATGGAATAAAGATGGAAAAA
TTTGTCTTTGACATCTTCCAGTTTGCAAAGAAGTTTGTGGTATATGAAGTATTGCGAGAA
GATGAGTTTTCCCCACTAAAGAATGCTGATAGTCAGAATGGGAAAGACAACCCTACTACT
GCAAGGCATGCTTTGATGTCCCTTCATCATTGCTGGGTCCTCAATGCAGGGGGCCATTTC
ATAGATGAAAATAGCTCTCGCCTTCCAGCAATTCCCCGCTTGAAGGATGCCAATGATGTA
CCAATCCAATGTGAAATCTCTCCTCTTATCTCCTATGCTGGAGAAGGATTAGAAAGTTAT
GTGGCAGATAAAGAATTCCATGCACCTCTAATCATCGATGAGAATGGAGTTCATGAGCTG
GTGAAAAATGGTATTTGA
PF01704
UDPGP
function
nucleotidyltransferase activity
function
catalytic activity
function
transferase activity
function
transferase activity, transferring phosphorus-containing groups
process
physiological process
process
metabolism
BE0001521
UDP-glucose 4-epimerase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-glucose 4-epimerase
Cell wall/membrane/envelope biogenesis
Catalyzes two distinct but analogous reactions:the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine
GALE
1p36-p35
None
6.71
38282.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4116
GenAtlas
GALE
GeneCards
GALE
GenBank Gene Database
L41668
GenBank Protein Database
1119217
UniProtKB
Q14376
UniProt Accession
GALE_HUMAN
EC 5.1.3.2
Galactowaldenase
UDP-galactose 4-epimerase
>UDP-glucose 4-epimerase
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK
AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA
VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD
YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
>1047 bp
ATGGCAGAGAAGGTGCTGGTAACAGGTGGGGCTGGCTACATTGGCAGCCACACGGTGCTG
GAGCTGCTGGAGGCTGGCTACTTGCCTGTGGTCATCGATAACTTCCATAATGCCTTCCGT
GGAGGGGGCTCCCTGCCTGAGAGCCTGCGGCGGGTCCAGGAGCTGACAGGCCGCTCTGTG
GAGTTTGAGGAGATGGACATTTTGGACCAGGGAGCCCTACAGCGTCTCTTCAAAAAGTAC
AGCTTTATGGCGGTCATCCACTTTGCGGGGCTCAAGGCCGTGGGCGAGTCGGTGCAGAAG
CCTCTGGATTATTACAGAGTTAACCTGACCGGGACCATCCAGCTTCTGGAGATCATGAAG
GCCCACGGGGTGAAGAACCTGGTGTTCAGCAGCTCAGCCACTGTGTACGGGAACCCCCAG
TACCTGCCCCTTGATGAGGCCCACCCCACGGGTGGTTGTACCAACCCTTACGGCAAGTCC
AAGTTCTTCATCGAGGAAATGATCCGGGACCTGTGCCAGGCAGACAAGACTTGGAACGTA
GTGCTGCTGCGCTATTTCAACCCCACAGGTGCCCATGCCTCTGGCTGCATTGGTGAGGAT
CCCCAGGGCATACCCAACAACCTCATGCCTTATGTCTCCCAGGTGGCGATCGGGCGACGG
GAGGCCCTGAATGTCTTTGGCAATGACTATGACACAGAGGATGGCACAGGTGTCCGGGAT
TACATCCATGTCGTGGATCTGGCCAAGGGCCACATTGCAGCCTTAAGGAAGCTGAAAGAA
CAGTGTGGCTGCCGGATCTACAACCTGGGCACGGGCACAGGCTATTCAGTGCTGCAGATG
GTCCAGGCTATGGAGAAGGCCTCTGGGAAGAAGATCCCGTACAAGGTGGTGGCACGGCGG
GAAGGTGATGTGGCAGCCTGTTACGCCAACCCCAGCCTGGCCCAAGAGGAGCTGGGGTGG
ACAGCAGCCTTAGGGCTGGACAGGATGTGTGAGGATCTCTGGCGCTGGCAGAAGCAGAAT
CCTTCAGGCTTTGGCACGCAAGCCTGA
PF01370
Epimerase
function
catalytic activity
function
NAD binding
function
racemase and epimerase activity
function
cofactor binding
function
racemase and epimerase activity, acting on carbohydrates and derivatives
function
coenzyme binding
function
UDP-glucose 4-epimerase activity
function
isomerase activity
function
binding
process
hexose metabolism
process
metabolism
process
cellular metabolism
process
nucleotide-sugar metabolism
process
macromolecule metabolism
process
galactose metabolism
process
carbohydrate metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
alcohol metabolism
process
physiological process
process
monosaccharide metabolism
BE0001428
UDP-N-acetylglucosamine 2-epimerase
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-N-acetylglucosamine 2-epimerase
Cell wall/membrane/envelope biogenesis
Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption
wecB
Cytoplasm
None
6.32
42245.0
Escherichia coli (strain K12)
GenBank Gene Database
M87049
GenBank Protein Database
148189
UniProtKB
P27828
UniProt Accession
WECB_ECOLI
Bacteriophage N4 adsorption protein C
EC 5.1.3.14
UDP-GlcNAc-2- epimerase
>UDP-N-acetylglucosamine 2-epimerase
MKVLTVFGTRPEAIKMAPLVHALAKDPFFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNI
MQPGQGLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGL
RTGDLYSPWPEEANRTLTGHLAMYHFSPTETSRQNLLRENVADSRIFITGNTVIDALLWV
RDQVMSSDKLRSELAANYPFIDPDKKMILVTGHRRESFGRGFEEICHALADIATTHQDIQ
IVYPVHLNPNVREPVNRILGHVKNVILIDPQEYLPFVWLMNHAWLILTDSGGIQEEAPSL
GKPVLVMRDTTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAMSRAHNPYGDGQ
ACSRILEALKNNRISL
>1131 bp
GTGAAAGTACTGACTGTATTTGGTACGCGCCCGGAAGCCATCAAGATGGCGCCGTTGGTG
CATGCGTTGGCAAAAGATCCTTTTTTTGAGGCTAAAGTTTGCGTCACTGCGCAGCATCGG
GAGATGCTCGATCAGGTGCTGAAACTCTTTTCCATTGTACCTGACTACGATCTCAACATA
ATGCAGCCAGGACAGGGCCTGACAGAGATAACCTGTCGGATTCTGGAAGGGCTAAAACCT
ATTCTTGCCGAGTTCAAACCAGACGTCGTGCTGGTTCACGGCGATACGACGACGACGCTG
GCAACCAGCCTGGCGGCGTTTTATCAGCGTATTCCTGTTGGTCACGTTGAGGCTGGTCTG
CGCACGGGCGATCTCTATTCGCCGTGGCCGGAAGAGGCTAACCGTACATTGACCGGGCAT
CTGGCGATGTATCACTTCTCTCCAACCGAAACTTCCCGGCAAAACTTGCTGCGTGAAAAC
GTTGCGGATAGCCGAATCTTCATTACCGGTAATACAGTCATTGATGCACTGTTATGGGTG
CGTGACCAGGTGATGAGCAGCGACAAGCTGCGTTCAGAACTGGCGGCAAATTACCCGTTT
ATCGACCCCGATAAAAAGATGATTCTGGTGACCGGTCACAGGCGTGAGAGTTTCGGTCGT
GGCTTTGAAGAAATCTGCCACGCGCTGGCAGACATCGCCACCACGCACCAGGACATCCAG
ATTGTCTATCCGGTGCATCTCAACCCGAACGTCAGAGAACCGGTCAATCGCATTCTGGGG
CATGTGAAAAATGTCATTCTGATCGATCCCCAGGAGTATTTACCGTTTGTCTGGCTGATG
AACCACGCCTGGCTGATTTTGACCGACTCAGGCGGCATTCAGGAAGAAGCGCCTTCGCTG
GGGAAACCTGTGCTGGTGATGCGCGATACCACTGAGCGTCCGGAAGCGGTGACGGCGGGT
ACGGTGCGTCTGGTAGGCACGGATAAGCAGCGAATTGTCGAGGAAGTGACGCGTCTTTTA
AAAGACGAAAACGAATATCAAGCTATGAGCCGCGCCCATAACCCGTATGGTGATGGTCAG
GCATGCTCTCGCATTCTGGAAGCGTTAAAAAATAATCGGATATCACTATGA
PF02350
Epimerase_2
function
racemase and epimerase activity
function
catalytic activity
function
racemase and epimerase activity, acting on carbohydrates and derivatives
function
UDP-N-acetylglucosamine 2-epimerase activity
function
isomerase activity
process
nitrogen compound metabolism
process
UDP-N-acetylglucosamine metabolism
process
amine metabolism
process
amino sugar metabolism
process
glucosamine metabolism
process
physiological process
process
N-acetylglucosamine metabolism
process
metabolism
process
carbohydrate biosynthesis
process
macromolecule metabolism
process
macromolecule biosynthesis
process
polysaccharide biosynthesis
process
lipopolysaccharide biosynthesis
BE0000214
Histo-blood group ABO system transferase
Human
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Histo-blood group ABO system transferase
Involved in transferase activity, transferring hexosyl groups
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens:A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity
ABO
9q34.1-q34.2
Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Membrane-b
33-53
9.24
40934.0
Human
HUGO Gene Nomenclature Committee (HGNC)
HGNC:79
GenAtlas
ABO
GeneCards
ABO
GenBank Gene Database
J05175
GenBank Protein Database
340078
UniProtKB
P16442
UniProt Accession
BGAT_HUMAN
A transferase)
EC 2.4.1.37
EC 2.4.1.40
Fucosylglycoprotein 3-alpha- galactosyltransferase
Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
Glycoprotein-fucosylgalactoside alpha- galactosyltransferase
Histo-blood group A transferase
Histo-blood group B transferase
NAGAT
>Histo-blood group ABO system transferase
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDH
LQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTV
FAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKR
WQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSS
REAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVW
HDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
>1062 bp
ATGGCCGAGGTGTTGCGGACGCTGGCCGGAAAACCAAAATGCCACGCACTTCGACCTATG
ATCCTTTTCCTAATAATGCTTGTCTTGGTCTTGTTTGGTTACGGGGTCCTAAGCCCCAGA
AGTCTAATGCCAGGAAGCCTGGAACGGGGGTTCTGCATGGCTGTTAGGGAACCTGACCAT
CTGCAGCGCGTCTCGTTGCCAAGGATGGTCTACCCCCAGCCAAAGGTGCTGACACCGTGG
AAGGATGTCCTCGTGGTGACCCCTTGGCTGGCTCCCATTGTCTGGGAGGGCACATTCAAC
ATCGACATCCTCAACGAGCAGTTCAGGCTCCAGAACACCACCATTGGGTTAACTGTGTTT
GCCATCAAGAAATACGTGGCTTTCCTGAAGCTGTTCCTGGAGACGGCGGAGAAGCACTTC
ATGGTGGGCCACCGTGTCCACTACTATGTCTTCACCGACCAGCTGGCCGCGGTGCCCCGC
GTGACGCTGGGGACCGGTCGGCAGCTGTCAGTGCTGGAGGTGCGCGCCTACAAGCGCTGG
CAGGACGTGTCCATGCGCCGCATGGAGATGATCAGTGACTTCTGCGAGCGGCGCTTCCTC
AGCGAGGTGGATTACCTGGTGTGCGTGGACGTGGACATGGAGTTCCGCGACCACGTGGGC
GTGGAGATCCTGACTCCGCTGTTCGGCACCCTGCACCCCGGCTTCTACGGAAGCAGCCGG
GAGGCCTTCACCTACGAGCGCCGGCCCCAGTCCCAGGCCTACATCCCCAAGGACGAGGGC
GATTTCTACTACCTGGGGGGGTTCTTCGGGGGGTCGGTGCAAGAGGTGCAGCGGCTCACC
AGGGCCTGCCACCAGGCCATGATGGTCGACCAGGCCAACGGCATCGAGGCCGTGTGGCAC
GACGAGAGCCACCTGAACAAGTACCTGCTGCGCCACAAACCCACCAAGGTGCTCTCCCCC
GAGTACTTGTGGGACCAGCAGCTGCTGGGCTGGCCCGCCGTCCTGAGGAAGCTGAGGTTC
ACTGCGGTGCCCAAGAACCACCAGGCGGTCCGGAACCCGTGA
PF03414
Glyco_transf_6
component
cell
component
membrane
function
transferase activity, transferring glycosyl groups
function
transferase activity, transferring hexosyl groups
function
catalytic activity
function
transferase activity
process
carbohydrate metabolism
process
physiological process
process
metabolism
process
macromolecule metabolism
BE0001454
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Cell wall/membrane/envelope biogenesis
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
murG
Cell inner membrane; peripheral membrane protein
None
10.32
37815.0
Escherichia coli (strain K12)
GenBank Gene Database
X52644
GenBank Protein Database
809684
UniProtKB
P17443
UniProt Accession
MURG_ECOLI
EC 2.4.1.227
pentapeptide
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
>UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFI
RISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIP
VVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGRE
GPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKV
TEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGA
AKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRVARA
>1068 bp
ATGAGTGGTCAAGGAAAGCGATTAATGGTGATGGCAGGCGGAACCGGTGGACATGTATTC
CCGGGACTGGCGGTTGCGCACCATCTAATGGCTCAGGGTTGGCAAGTTCGCTGGCTGGGG
ACTGCCGACCGTATGGAAGCGGACTTAGTGCCAAAACATGGCATCGAAATTGATTTCATT
CGTATCTCTGGTCTGCGTGGAAAAGGTATAAAAGCACTGATAGCTGCCCCGCTGCGTATC
TTCAACGCCTGGCGTCAGGCGCGGGCGATTATGAAAGCGTACAAACCTGACGTGGTGCTC
GGTATGGGAGGCTACGTGTCAGGTCCAGGTGGTCTGGCCGCGTGGTCGTTAGGCATTCCG
GTTGTACTTCATGAACAAAACGGTATTGCGGGCTTAACCAATAAATGGCTGGCGAAGATT
GCCACCAAAGTGATGCAGGCGTTTCCAGGTGCTTTCCCTAATGCGGAAGTAGTGGGTAAC
CCGGTGCGTACCGATGTGTTGGCGCTGCCGTTGCCGCAGCAACGTTTGGCTGGACGTGAA
GGTCCGGTTCGTGTGCTGGTAGTGGGTGGTTCTCAGGGCGCACGCATTCTTAACCAGACA
ATGCCGCAGGTTGCTGCGAAACTGGGTGATTCAGTCACTATCTGGCATCAGAGCGGCAAA
GGTTCGCAACAATCCGTTGAACAGGCGTATGCCGAAGCGGGGCAACCGCAGCATAAAGTG
ACGGAATTTATTGATGATATGGCGGCGGCGTATGCGTGGGCGGATGTCGTCGTTTGCCGC
TCCGGTGCGTTAACGGTGAGTGAAATCGCCGCGGCAGGACTACCGGCGTTGTTTGTGCCG
TTTCAACATAAAGACCGCCAGCAATACTGGAATGCGCTACCGCTGGAAAAAGCGGGCGCA
GCCAAAATTATCGAGCAGCCACAGCTTAGCGTGGATGCTGTCGCCAACACCCTGGCCGGG
TGGTCGCGAGAAACCTTATTAACCATGGCAGAACGCGCCCGCGCTGCATCCATTCCGGAT
GCCACCGAGCGAGTGGCAAATGAAGTGAGCCGGGTTGCCCGGGCGTAA
PF04101
Glyco_tran_28_C
PF03033
Glyco_transf_28
component
membrane
component
organelle membrane
component
organelle inner membrane
component
cell
function
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
function
catalytic activity
function
transferase activity
function
transferase activity, transferring glycosyl groups
function
transferase activity, transferring hexosyl groups
function
carbohydrate binding
function
UDP-glycosyltransferase activity
function
binding
function
acetylglucosaminyltransferase activity
process
lipid modification
process
metabolism
process
lipid glycosylation
process
macromolecule metabolism
process
nitrogen compound metabolism
process
biopolymer metabolism
process
amine metabolism
process
biopolymer modification
process
amino sugar metabolism
process
UDP-N-acetylgalactosamine metabolism
process
UDP-N-acetylgalactosamine biosynthesis
process
carbohydrate metabolism
process
physiological process
BE0002630
WbpP
Pseudomonas aeruginosa
unknown
WbpP
Involved in catalytic activity
None
6.37
37749.0
Pseudomonas aeruginosa
GenBank Gene Database
AF498417
UniProtKB
Q8KN66
UniProt Accession
Q8KN66_PSEAI
>WbpP
MMSRYEELRKELPAQPKVWLITGVAGFIGSNLLETLLKLDQKVVGLDNFATGHQRNLDEV
RSLVSEKQWSNFKFIQGDIRNLDDCNNACAGVDYVLHQAALGSVPRSINDPITSNATNID
GFLNMLIAARDAKVQSFTYAASSSTYGDHPGLPKVEDTIGKPLSPYAVTKYVNELYADVF
SRCYGFSTIGLRYFNVFGRRQDPNGAYAAVIPKWTSSMIQGDDVYINGDGETSRDFCYIE
NTVQANLLAATAGLDARNQVYNIAVGGRTSLNQLFFALRDGLAENGVSYHREPVYRDFRE
GDVRHSLADISKAAKLLGYAPKYDVSAGVALAMPWYIMFLK
>1026 bp
ATGATGAGTCGTTATGAAGAGCTAAGAAAGGAATTGCCGGCGCAGCCGAAAGTCTGGCTG
ATTACAGGTGTGGCGGGCTTTATTGGCTCTAATCTTCTTGAGACTTTGCTAAAGCTTGAT
CAGAAGGTTGTCGGTCTGGATAATTTTGCTACTGGTCATCAGCGGAACCTGGACGAAGTG
CGGTCCTTGGTTAGCGAGAAGCAATGGTCAAATTTTAAATTTATTCAAGGTGATATTCGC
AATCTGGATGATTGCAATAACGCCTGTGCAGGTGTTGATTACGTTTTACATCAAGCTGCC
TTGGGTTCGGTACCGCGTTCTATTAACGATCCGATCACCTCCAATGCAACGAACATCGAT
GGTTTCTTGAATATGCTGATTGCAGCCAGAGATGCCAAGGTGCAGAGTTTCACTTATGCG
GCAAGTAGCTCTACCTATGGAGATCATCCTGGTTTACCGAAGGTGGAGGATACTATAGGT
AAGCCTCTTTCCCCTTATGCGGTTACCAAATATGTGAATGAGCTTTATGCCGATGTGTTT
TCACGCTGCTACGGCTTTTCGACCATTGGGCTTCGTTATTTCAATGTGTTCGGTCGTCGA
CAGGATCCCAATGGTGCCTATGCGGCAGTCATACCAAAATGGACCTCTTCGATGATCCAG
GGTGATGACGTCTATATTAACGGTGATGGCGAGACCAGTCGGGATTTTTGTTATATTGAA
AACACCGTTCAGGCCAATCTGCTTGCTGCAACCGCGGGGCTTGATGCTCGTAATCAAGTT
TACAATATTGCTGTTGGCGGGCGGACGAGTTTGAATCAGTTGTTCTTTGCGCTTCGCGAC
GGCCTTGCCGAAAACGGTGTGTCCTATCACCGGGAACCTGTTTATCGTGATTTTAGGGAG
GGGGATGTACGTCACTCTCTCGCTGATATCAGCAAGGCTGCCAAACTGCTGGGGTATGCG
CCGAAATATGATGTGTCTGCAGGTGTGGCGTTGGCCATGCCTTGGTACATCATGTTTTTG
AAATGA
PF01370
Epimerase
function
cofactor binding
function
coenzyme binding
function
isomerase activity
function
binding
function
NAD binding
function
catalytic activity
function
racemase and epimerase activity
function
racemase and epimerase activity, acting on carbohydrates and derivatives
process
carbohydrate metabolism
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
physiological process
process
nucleotide-sugar metabolism
process
metabolism
process
cellular metabolism
process
macromolecule metabolism
"
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All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object