Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB02181"

Predicate	Value (sorted: none)
rdf:type	drugbank:drugs
rdfs:label	"2'-Deoxyguanosine-5'-Triphosphate"
owl:sameAs	drug:EXPT01184
drugbank:description	" 2564-35-4 experimental Carl W. Fuller, Mark McDougall, Shiv Kumar, "Derivatives of 7-deaza -2'-deoxyguanosine-5'-triphosphate, preparation and use thereof." U.S. Patent US06906185, issued June 14, 2005. This compound belongs to the purine ribonucleoside triphosphates. These are purine ribobucleotides with triphosphate group linked to the ribose moiety. Purine Ribonucleoside Triphosphates Organic Compounds Organooxygen Compounds Carbohydrates and Carbohydrate Conjugates Glycosyl Compounds Organic Pyrophosphates Pentoses Hypoxanthines Pyrimidones N-substituted Imidazoles Primary Aromatic Amines Organic Phosphoric Acids Organophosphate Esters Tetrahydrofurans Oxolanes Secondary Alcohols Polyamines Ethers organic pyrophosphate hypoxanthine pentose monosaccharide purine imidazopyrimidine pyrimidone n-substituted imidazole phosphoric acid ester monosaccharide primary aromatic amine organic phosphate pyrimidine tetrahydrofuran imidazole azole oxolane secondary alcohol polyamine ether alcohol primary amine organonitrogen compound amine logP -0.61 ALOGPS logS -2 ALOGPS Water Solubility 5.59e+00 g/l ALOGPS logP -2.8 ChemAxon IUPAC Name ({[({[(2S,3R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid ChemAxon Traditional IUPAC Name ({[(2S,3R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid ChemAxon Molecular Weight 507.181 ChemAxon Monoisotopic Weight 506.995745159 ChemAxon SMILES NC1=NC2=C(N=CN2[C@H]2C[C@@H](O)[C@H](CO[P@@](O)(=O)O[P@](O)(=O)OP(O)(O)=O)O2)C(=O)N1 ChemAxon Molecular Formula C10H16N5O13P3 ChemAxon InChI InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6-/m1/s1 ChemAxon InChIKey InChIKey=HAAZLUGHYHWQIW-NGJCXOISSA-N ChemAxon Polar Surface Area (PSA) 274.58 ChemAxon Refractivity 95.73 ChemAxon Polarizability 38.39 ChemAxon Rotatable Bond Count 8 ChemAxon H Bond Acceptor Count 13 ChemAxon H Bond Donor Count 7 ChemAxon pKa (strongest acidic) 0.82 ChemAxon pKa (strongest basic) 1.61 ChemAxon Physiological Charge -3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 0 ChemAxon MDDR-Like Rule true ChemAxon ChEBI 16497 PubChem Compound 13602803 PubChem Substance 46506790 KEGG Compound C00286 BindingDB 21687 PDB DGT BE0003106 Nucleoside diphosphate kinase A Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Nucleoside diphosphate kinase A Involved in nucleoside diphosphate kinase activity Major role in the synthesis of nucleoside triphosphates other than ATP NME1 17q21.3 Cytoplasm. Nucleus None 6.11 17149.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:7849 GenAtlas NME1 GenBank Gene Database X75598 UniProtKB P15531 UniProt Accession NDKA_HUMAN EC 2.7.4.6 GAAD Granzyme A-activated DNase Metastasis inhibition factor nm23 NDK A NDP kinase A nm23-H1 Tumor metastatic process-associated protein >Nucleoside diphosphate kinase A MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPF FAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS DSVESAEKEIGLWFHPEELVDYTSCAQNWIYE >459 bp ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTT GTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAATTC ATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGG CTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAG CCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGAACATTATACATGGCAGT GATTCTGTGGAGAGTGCAGAGAAGGAGATCGGCTTGTGGTTTCACCCTGAGGAACTGGTA GATTACACGAGCTGTGCTCAGAACTGGATCTATGAATGA PF00334 NDK function catalytic activity function nucleotide binding function phosphotransferase activity, phosphate group as acceptor function ion binding function metal ion binding function purine nucleotide binding function magnesium ion binding function adenyl nucleotide binding function nucleoside diphosphate kinase activity function transferase activity function ATP binding function binding function transferase activity, transferring phosphorus-containing groups process nucleotide metabolism process pyrimidine ribonucleoside triphosphate biosynthesis process metabolism process purine nucleotide metabolism process UTP biosynthesis process cellular metabolism process purine nucleotide biosynthesis process purine nucleoside triphosphate biosynthesis process purine ribonucleoside triphosphate biosynthesis process GTP biosynthesis process CTP biosynthesis process nucleoside triphosphate metabolism process nucleoside triphosphate biosynthesis process physiological process process nucleobase, nucleoside, nucleotide and nucleic acid metabolism process ribonucleoside triphosphate biosynthesis BE0001442 Anaerobic ribonucleoside-triphosphate reductase Enterobacteria phage T4 # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Anaerobic ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin NRDD None 7.06 67957.0 Enterobacteria phage T4 GenBank Gene Database Y00122 GenBank Protein Database 1177560 UniProtKB P07071 UniProt Accession NRDD_BPT4 EC 1.17.4.2 >Anaerobic ribonucleoside-triphosphate reductase MTIEKEIEGLIHKTNKDLLNENANKDSRVFPTQRDLMAGIVSKHIAKNMVPSFIMKAHES GIIHVHDIDYSPALPFTNCCLVDLKGMLENGFKLGNAQIETPKSIGVATAIMAQITAQVA SHQYGGTTFANVDKVLSPYVKRTYAKHIEDAEKWQIADALNYAQSKTEKDVYDAFQAYEY EVNTLFSSNGQTPFVTITFGTGTDWTERMIQKAILKNRIKGLGRDGITPIFPKLVMFVEE GVNLYKDDPNYDIKQLALECASKRMYPDIISAKNNKAITGSSVPVSPMGCRSFLSVWKDS TGNEILDGRNNLGVVTLNLPRIALDSYIGTQFNEQKFVELFNERMDLCFEALMCRISSLK GVKATVAPILYQEGAFGVRLKPDDDIIELFKNGRSSVSLGYIGIHELNILVGRDIGREIL TKMNAHLKQWTERTGFAFSLYSTPAENLCYRFCKLDTEKYGSVKDVTDKGWYTNSFHVSV EENITPFEKISREAPYHFIATGGHISYVELPDMKNNLKGLEAVWDYAAQHLDYFGVNMPV DKCFTCGSTHEMTPTENGFVCSICGETDPKKMNTIRRTCGYLGNPNERGFNLGKNKEIMH RVKHQ >1818 bp ATGACAATTGAAAAAGAAATTGAAGGATTAATTCATAAAACTAATAAAGACCTTTTAAAC GAGAATGCTAATAAAGATTCTCGTGTTTTTCCAACTCAACGGGACCTTATGGCTGGTATT GTGTCTAAACACATTGCCAAAAATATGGTCCCGTCTTTTATTATGAAAGCGCATGAAAGC GGAATTATTCACGTGCATGATATTGATTATTCCCCTGCTCTTCCATTTACTAATTGCTGT TTAGTAGATTTAAAAGGAATGCTTGAAAACGGATTTAAGCTTGGTAATGCGCAGATTGAA ACTCCTAAATCAATTGGAGTTGCTACTGCAATTATGGCACAAATTACTGCGCAAGTTGCT TCTCACCAATACGGCGGAACGACTTTTGCGAATGTAGATAAAGTACTTTCTCCTTATGTT AAACGCACCTATGCAAAACATATTGAGGATGCAGAAAAATGGCAAATCGCTGATGCGTTG AATTATGCTCAATCTAAAACAGAAAAAGACGTATACGATGCATTCCAAGCTTATGAGTAT GAAGTGAACACGTTATTCAGTTCAAACGGACAGACTCCTTTTGTAACAATTACATTTGGT ACGGGAACTGACTGGACTGAACGAATGATTCAGAAAGCAATTCTGAAAAATCGTATTAAA GGTCTTGGTCGTGATGGGATAACTCCTATTTTCCCTAAGCTTGTTATGTTCGTTGAAGAA GGTGTTAATCTTTATAAAGACGATCCGAACTATGATATTAAACAGCTTGCTCTAGAGTGC GCAAGCAAAAGGATGTATCCTGATATTATTTCAGCTAAGAACAATAAAGCTATCACTGGT TCATCTGTTCCTGTTTCTCCGATGGGTTGCCGTAGTTTCTTGAGCGTATGGAAAGATTCG ACTGGCAATGAAATTCTTGATGGACGCAATAATCTTGGTGTTGTAACACTGAATCTTCCT CGCATCGCGTTAGATTCTTATATTGGAACACAGTTCAATGAACAGAAATTTGTTGAGCTA TTTAATGAACGAATGGATTTATGTTTTGAAGCTTTGATGTGTAGAATTAGTTCCTTAAAA GGAGTTAAAGCTACTGTTGCTCCTATTCTTTACCAAGAAGGTGCATTCGGGGTTCGTCTT AAACCTGATGACGACATAATTGAGTTATTTAAAAACGGTAGAAGTTCAGTGTCTTTAGGA TACATTGGTATTCACGAATTGAATATTCTTGTCGGTCGTGATATTGGACGAGAAATTTTA ACTAAAATGAATGCTCATCTTAAACAGTGGACTGAAAGAACCGGATTTGCTTTTAGTTTA TATTCGACTCCTGCTGAAAACCTGTGTTATCGCTTCTGTAAACTCGATACAGAAAAATAT GGAAGCGTAAAAGATGTTACCGATAAAGGCTGGTACACTAACAGTTTCCATGTTTCAGTA GAAGAAAATATTACTCCGTTTGAAAAGATTTCTCGTGAAGCGCCATATCATTTCATTGCG ACAGGTGGTCACATTTCTTATGTTGAACTTCCTGATATGAAAAATAACTTAAAAGGTCTT GAGGCCGTGTGGGATTATGCTGCACAGCATTTAGATTATTTTGGTGTTAATATGCCAGTA GATAAATGTTTTACATGTGGAAGTACCCATGAAATGACTCCTACTGAAAACGGATTTGTT TGTTCTATTTGTGGAGAAACTGATCCTAAAAAGATGAATACCATAAGAAGAACATGTGGT TATTTGGGAAATCCGAACGAACGCGGATTTAATCTCGGTAAAAATAAAGAAATCATGCAT AGGGTTAAGCACCAATGA PF01228 Gly_radical function catalytic activity process physiological process process metabolism "

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource does not appear as an object

Context graph