Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB02041"
| Predicate | Value (sorted: none) |
|---|---|
| drugbank:drugCategory | |
| rdf:type | |
| drugbank:description |
"
experimental
This compound belongs to the phthalazinones. These are compounds containing a phthalazine bearing a ketone group.
Phthalazinones
Organic Compounds
Heterocyclic Compounds
Naphthyridines
Phthalazines
Pyridazinones
Anilines
Primary Aromatic Amines
Polyamines
aniline
pyridazinone
benzene
primary aromatic amine
pyridazine
polyamine
amine
primary amine
organonitrogen compound
Luminescent Agents
logP
-0.39
ALOGPS
logS
-1.9
ALOGPS
Water Solubility
2.43e+00 g/l
ALOGPS
logP
-0.71
ChemAxon
IUPAC Name
6-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione
ChemAxon
Traditional IUPAC Name
4-aminophthalhydrazide
ChemAxon
Molecular Weight
177.1601
ChemAxon
Monoisotopic Weight
177.053826483
ChemAxon
SMILES
NC1=CC=C2C(=O)NNC(=O)C2=C1
ChemAxon
Molecular Formula
C8H7N3O2
ChemAxon
InChI
InChI=1S/C8H7N3O2/c9-4-1-2-5-6(3-4)8(13)11-10-7(5)12/h1-3H,9H2,(H,10,12)(H,11,13)
ChemAxon
InChIKey
InChIKey=HUDPLKWXRLNSPC-UHFFFAOYSA-N
ChemAxon
Polar Surface Area (PSA)
84.22
ChemAxon
Refractivity
47.32
ChemAxon
Polarizability
16.46
ChemAxon
Rotatable Bond Count
0
ChemAxon
H Bond Acceptor Count
3
ChemAxon
H Bond Donor Count
3
ChemAxon
pKa (strongest acidic)
13.75
ChemAxon
pKa (strongest basic)
2.15
ChemAxon
Physiological Charge
0
ChemAxon
Number of Rings
2
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
PubChem Compound
95014
PubChem Substance
46508392
ChemSpider
393041
PDB
APZ
BE0001405
Queuine tRNA-ribosyltransferase
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Queuine tRNA-ribosyltransferase
Translation, ribosomal structure and biogenesis
Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
tgt
None
6.85
42843.0
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
GenBank Gene Database
L33777
GenBank Protein Database
498141
UniProtKB
P28720
UniProt Accession
TGT_ZYMMO
EC 2.4.2.29
Guanine insertion enzyme
tRNA-guanine transglycosylase
>Queuine tRNA-ribosyltransferase
MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEE
GVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAK
RSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEM
FRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPI
NIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQK
IRDSISEGRFSQFAQDFRARYFARNS
>1200 bp
ATGAGCTTGGAAATGATGACGGCAGTCAAAGGAAGAAATGTGGTAGAAGCAACAGCGCAA
GAGACCGATCGTCCGCGTTTTTCTTTTTCAATCGCGGCAAGGGAAGGAAAAGCCCGCACC
GGCACTATCGAAATGAAGCGGGGCGTTATCCGAACCCCTGCCTTTATGCCGGTTGGCACG
GCAGCTACCGTAAAGGCTTTAAAGCCGGAAACAGTTCGGGCAACTGGCGCTGATATTATC
TTGGGGAATACCTATCATCTGATGCTTCGTCCGGGTGCCGAACGGATAGCTAAGCTGGGC
GGATTACATTCTTTTATGGGGTGGGATCGGCCTATTTTGACGGATAGCGGCGGGTATCAG
GTGATGAGCCTATCTTCTTTGACGAAGCAGAGCGAAGAGGGCGTTACCTTTAAAAGTCAC
CTTGACGGTTCCCGCCATATGCTGTCGCCGGAACGTTCTATCGAAATCCAGCATTTACTA
GGCAGTGATATCGTAATGGCCTTTGACGAATGCACGCCTTATCCAGCAACGCCTTCGCGC
GCGGCCTCGTCAATGGAACGCTCGATGCGGTGGGCGAAAAGATCACGGGATGCCTTTGAT
AGCCGAAAAGAACAGGCAGAAAATGCGGCTTTGTTCGGAATTCAACAAGGTTCTGTTTTT
GAAAATCTGCGGCAACAATCGGCGGATGCTCTGGCTGAAATCGGCTTTGATGGCTATGCT
GTTGGGGGATTGGCTGTGGGTGAAGGACAGGATGAAATGTTCCGTGTCCTTGATTTTTCT
GTGCCGATGCTGCCCGATGACAAACCTCATTATCTTATGGGCGTTGGTAAGCCTGATGAT
ATCGTTGGAGCGGTTGAACGCGGCATTGATATGTTCGATTGCGTCTTGCCGACACGTTCC
GGTCGGAATGGGCAAGCCTTTACATGGGATGGGCCTATCAATATCAGAAATGCCCGTTTT
TCAGAAGATTTGAAGCCGTTGGATAGTGAATGTCATTGTGCCGTTTGCCAGAAATGGAGC
CGCGCCTATATCCATCATTTAATTCGGGCGGGTGAGATCTTGGGGGCTATGCTGATGACA
GAGCATAATATCGCCTTTTATCAACAGCTTATGCAAAAAATACGGGACTCTATTTCGGAG
GGGCGTTTTTCGCAATTTGCTCAGGATTTCAGAGCGCGCTATTTCGCACGGAATAGCTAG
PF01702
TGT
function
transferase activity, transferring pentosyl groups
function
queuine tRNA-ribosyltransferase activity
function
catalytic activity
function
transferase activity
function
transferase activity, transferring glycosyl groups
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
process
RNA metabolism
process
tRNA metabolism
process
physiological process
process
tRNA modification
process
queuosine biosynthesis
process
metabolism
process
cellular metabolism
"
|
| rdfs:label |
"4-Aminophthalhydrazide"
|
| owl:sameAs |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object