Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01936"
| Predicate | Value (sorted: none) |
|---|---|
| drugbank:description |
"
50-69-1
experimental
Fabienne Chatreaux, Michel Klich, Laurent Schio, "Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments." U.S. Patent US5968939, issued January, 1969.
This compound belongs to the pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms.
Pentoses
Organic Compounds
Organooxygen Compounds
Carbohydrates and Carbohydrate Conjugates
Monosaccharides
Tetrahydrofurans
Oxolanes
Hemiacetals
Secondary Alcohols
1,2-Diols
Primary Alcohols
Polyamines
tetrahydrofuran
oxolane
secondary alcohol
polyol
hemiacetal
1,2-diol
polyamine
primary alcohol
ether
alcohol
logP
-2.6
ALOGPS
logS
0.85
ALOGPS
Water Solubility
1.07e+03 g/l
ALOGPS
logP
-2.3
ChemAxon
IUPAC Name
(2S,3S,4S,5R)-5-(hydroxymethyl)oxolane-2,3,4-triol
ChemAxon
Traditional IUPAC Name
ribose
ChemAxon
Molecular Weight
150.1299
ChemAxon
Monoisotopic Weight
150.05282343
ChemAxon
SMILES
OC[C@H]1O[C@H](O)[C@@H](O)[C@@H]1O
ChemAxon
Molecular Formula
C5H10O5
ChemAxon
InChI
InChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4+,5+/m1/s1
ChemAxon
InChIKey
InChIKey=HMFHBZSHGGEWLO-MBMOQRBOSA-N
ChemAxon
Polar Surface Area (PSA)
90.15
ChemAxon
Refractivity
29.96
ChemAxon
Polarizability
13.68
ChemAxon
Rotatable Bond Count
1
ChemAxon
H Bond Acceptor Count
5
ChemAxon
H Bond Donor Count
4
ChemAxon
pKa (strongest acidic)
11.31
ChemAxon
pKa (strongest basic)
-3
ChemAxon
Physiological Charge
0
ChemAxon
Number of Rings
1
ChemAxon
Bioavailability
1
ChemAxon
Rule of Five
true
ChemAxon
Melting Point
95 °C
PhysProp
logP
-2.32
HANSCH,C ET AL. (1995)
ChEBI
16988
PubChem Compound
9996708
PubChem Substance
46504941
KEGG Compound
C08353
ChemSpider
968
PDB
RIB
Wikipedia
Ribose
BE0001997
Ribokinase
Escherichia coli (strain K12)
# Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
unknown
Ribokinase
Carbohydrate transport and metabolism
ATP + D-ribose = ADP + D-ribose 5-phosphate
rbsK
Cytoplasm
None
4.73
32291.0
Escherichia coli (strain K12)
GenBank Gene Database
M13169
UniProtKB
P0A9J6
UniProt Accession
RBSK_ECOLI
EC 2.7.1.15
>Ribokinase
MQNAGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGANIAF
IACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAAL
SPALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNPAPARELPDELLAL
VDIITPNETEAEKLTGIRVENDEDAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRV
PGFRVQAVDTIAAGDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREE
IDAFLDRQR
PF00294
PfkB
function
transferase activity
function
transferase activity, transferring phosphorus-containing groups
function
phosphotransferase activity, alcohol group as acceptor
function
ribokinase activity
function
catalytic activity
process
metabolism
process
cellular metabolism
process
alcohol metabolism
process
monosaccharide metabolism
process
pentose metabolism
process
physiological process
process
D-ribose metabolism
"
|
| rdfs:label |
"Ribose"
|
| owl:sameAs | |
| rdf:type |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt
The resource does not appear as an object