Resource 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione

Predicate	Value (sorted: none)
owl:sameAs	drug:Cyclic Adenosine Monophosphate
owl:sameAs	drug:L-Aspartic Acid
owl:sameAs	drug:Zinc
owl:sameAs	drug:Adenosine
rdf:type	drugbank:drugs
owl:sameAs	drug:Hypoxanthine
owl:sameAs	drug:L-Glutamic Acid
owl:sameAs	drug:Azathioprine
owl:sameAs	drug:Fumarate
owl:sameAs	drug:Guanine
owl:sameAs	drug:S-Adenosylmethionine
owl:sameAs	drug:Tioguanine
owl:sameAs	drug:EXPT03202
rdfs:label	"7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione"
owl:sameAs	drug:Inosine
owl:sameAs	drug:L-Glutamine
owl:sameAs	drug:7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione
owl:sameAs	drug:Glycine
owl:sameAs	drug:Aicar
owl:sameAs	drug:Calcium
owl:sameAs	drug:Tetrahydrofolic acid
owl:sameAs	drug:Xanthine
owl:sameAs	drug:Potassium
drugbank:description	" 69-93-2 experimental This compound belongs to the xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety. Xanthines Organic Compounds Heterocyclic Compounds Imidazopyrimidines Purines and Purine Derivatives Purinones Pyrimidones Imidazoles Polyamines pyrimidone pyrimidine imidazole azole polyamine organonitrogen compound logP -1.1 ALOGPS logS -2 ALOGPS Water Solubility 1.76e+00 g/l ALOGPS logP -1.5 ChemAxon IUPAC Name 2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione ChemAxon Traditional IUPAC Name uric acid ChemAxon Molecular Weight 168.1103 ChemAxon Monoisotopic Weight 168.028340014 ChemAxon SMILES O=C1NC2=C(N1)C(=O)NC(=O)N2 ChemAxon Molecular Formula C5H4N4O3 ChemAxon InChI InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12) ChemAxon InChIKey InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 99.33 ChemAxon Refractivity 45.63 ChemAxon Polarizability 13.61 ChemAxon Rotatable Bond Count 0 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 4 ChemAxon pKa (strongest acidic) 7.61 ChemAxon pKa (strongest basic) -6.5 ChemAxon Physiological Charge 0 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Water Solubility 60 mg/L (at 20 Â°C) YALKOWSKY,SH & DANNENFELSER,RM (1992) logP -2.17 NAHUM,A & HORVATH,C (1980) pKa 5.4 KORTUM,G ET AL (1961) ChEBI 17775 PubChem Compound 1175 PubChem Substance 46505972 Drugs Product Database (DPD) 686042 KEGG Compound C00366 PDB URC SMP00427 Azathioprine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB00993 Azathioprine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00430 Thioguanine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00352 Tioguanine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00428 Mercaptopurine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00144 Adenosine Deaminase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00167 Adenylosuccinate Lyase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00168 AICA-Ribosiduria DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00203 Molybdenium Cofactor Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00537 Myoadenylate deaminase deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00210 Purine Nucleoside Phosphorylase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00536 Mitochondrial DNA depletion syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00365 Gout or Kelley-Seegmiller Syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00512 Xanthinuria type I DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00513 Xanthinuria type II DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00364 Lesch-Nyhan Syndrome (LNS) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00050 Purine Metabolism DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 BE0000007 Glycogen phosphorylase, liver form Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Glycogen phosphorylase, liver form Carbohydrate transport and metabolism Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties PYGL 14q21-q22 None 7.17 97019.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:9725 GenAtlas PYGL GeneCards PYGL GenBank Gene Database M14636 GenBank Protein Database 183353 UniProtKB P06737 UniProt Accession PYGL_HUMAN EC 2.4.1.1 >Glycogen phosphorylase, liver form AKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVR DHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIE ELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEAD DWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNT MRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVV AATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLP WSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPK DVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQ NKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQE NKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVP RTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPAT DLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAA LDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAY VKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNES NKVNGN >2544 bp ATGGGCGAACCGCTGACAGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG CGGGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC AAGAGGGAATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAGCTTGGATTGGATATA GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT GCTGCCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAGGTAGAAGAAGCA GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA GTGGTCCTGGCTCTGCCATATGACACCCCCGAGCCCGGCTACATGAATAACACTGTCAAC ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACTTTAATGTT GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC TATCCCAATGACAATTTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC CGTGGTCAAGGAACTGTGTTTGATGCCTTCCCGGATCAGGTGGCCATCCAGCTGAATGAT ACTCACCCTCGCATCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG CCCTGGTCCAAGGCATGGGAGCTCAACCAGAAGACCTTCGCCTACACCAACCACACAGTG CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGATAGAATTGTGGCCTTGTTTCCT AAAGATGTGGACCCTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC TCAGACATCGTGAAGACTAAAGTATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT GCAGAGCTCATAGCAGAGAAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC TGTCTGCATGTGATCACGATGTACAACCGCATTAAGAAAGACCCTAAGAAGTTATTCGTG CCAAGGACAGTTATCATTGGTGGTAAAGCTGCCCCAGGATATCACATGGCCAAAATGATC ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAGTCATTCCAGCC ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGCATAGATGATGTGGCT GCTTTGGACAAGAAAGGGTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA GATATCATCAACATGCTATTTTATCATGACAGGTTTAAAGTCTTTGCAGACTACGAAGCC TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATGAATCCAAAGGCCTGGAACACA ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA TCTAACAAAGTCAATGGAAATTGA PF00343 Phosphorylase function catalytic activity function vitamin binding function pyridoxal phosphate binding function transferase activity function transferase activity, transferring glycosyl groups function transferase activity, transferring hexosyl groups function phosphorylase activity function binding process metabolism process macromolecule metabolism process carbohydrate metabolism process physiological process "
owl:sameAs	drug:Guanosine
owl:sameAs	drug:Guanosine-5'-Monophosphate
owl:sameAs	drug:Mercaptopurine

"7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione"

owl:sameAs

drug:L-Glutamine

" 69-93-2 experimental This compound belongs to the xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety. Xanthines Organic Compounds Heterocyclic Compounds Imidazopyrimidines Purines and Purine Derivatives Purinones Pyrimidones Imidazoles Polyamines pyrimidone pyrimidine imidazole azole polyamine organonitrogen compound logP -1.1 ALOGPS logS -2 ALOGPS Water Solubility 1.76e+00 g/l ALOGPS logP -1.5 ChemAxon IUPAC Name 2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione ChemAxon Traditional IUPAC Name uric acid ChemAxon Molecular Weight 168.1103 ChemAxon Monoisotopic Weight 168.028340014 ChemAxon SMILES O=C1NC2=C(N1)C(=O)NC(=O)N2 ChemAxon Molecular Formula C5H4N4O3 ChemAxon InChI InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12) ChemAxon InChIKey InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N ChemAxon Polar Surface Area (PSA) 99.33 ChemAxon Refractivity 45.63 ChemAxon Polarizability 13.61 ChemAxon Rotatable Bond Count 0 ChemAxon H Bond Acceptor Count 3 ChemAxon H Bond Donor Count 4 ChemAxon pKa (strongest acidic) 7.61 ChemAxon pKa (strongest basic) -6.5 ChemAxon Physiological Charge 0 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Water Solubility 60 mg/L (at 20 Â°C) YALKOWSKY,SH & DANNENFELSER,RM (1992) logP -2.17 NAHUM,A & HORVATH,C (1980) pKa 5.4 KORTUM,G ET AL (1961) ChEBI 17775 PubChem Compound 1175 PubChem Substance 46505972 Drugs Product Database (DPD) 686042 KEGG Compound C00366 PDB URC SMP00427 Azathioprine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB00993 Azathioprine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00430 Thioguanine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00352 Tioguanine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00428 Mercaptopurine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00144 Adenosine Deaminase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00167 Adenylosuccinate Lyase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00168 AICA-Ribosiduria DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00203 Molybdenium Cofactor Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00537 Myoadenylate deaminase deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00210 Purine Nucleoside Phosphorylase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00536 Mitochondrial DNA depletion syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00365 Gout or Kelley-Seegmiller Syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00512 Xanthinuria type I DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00513 Xanthinuria type II DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00364 Lesch-Nyhan Syndrome (LNS) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00050 Purine Metabolism DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 BE0000007 Glycogen phosphorylase, liver form Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Glycogen phosphorylase, liver form Carbohydrate transport and metabolism Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties PYGL 14q21-q22 None 7.17 97019.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:9725 GenAtlas PYGL GeneCards PYGL GenBank Gene Database M14636 GenBank Protein Database 183353 UniProtKB P06737 UniProt Accession PYGL_HUMAN EC 2.4.1.1 >Glycogen phosphorylase, liver form AKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVR DHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIE ELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEAD DWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNT MRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVV AATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLP WSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPK DVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQ NKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQE NKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVP RTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPAT DLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAA LDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAY VKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNES NKVNGN >2544 bp ATGGGCGAACCGCTGACAGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG CGGGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC AAGAGGGAATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAGCTTGGATTGGATATA GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT GCTGCCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAGGTAGAAGAAGCA GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA GTGGTCCTGGCTCTGCCATATGACACCCCCGAGCCCGGCTACATGAATAACACTGTCAAC ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACTTTAATGTT GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC TATCCCAATGACAATTTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC CGTGGTCAAGGAACTGTGTTTGATGCCTTCCCGGATCAGGTGGCCATCCAGCTGAATGAT ACTCACCCTCGCATCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG CCCTGGTCCAAGGCATGGGAGCTCAACCAGAAGACCTTCGCCTACACCAACCACACAGTG CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGATAGAATTGTGGCCTTGTTTCCT AAAGATGTGGACCCTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC TCAGACATCGTGAAGACTAAAGTATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT GCAGAGCTCATAGCAGAGAAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC TGTCTGCATGTGATCACGATGTACAACCGCATTAAGAAAGACCCTAAGAAGTTATTCGTG CCAAGGACAGTTATCATTGGTGGTAAAGCTGCCCCAGGATATCACATGGCCAAAATGATC ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAGTCATTCCAGCC ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGCATAGATGATGTGGCT GCTTTGGACAAGAAAGGGTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA GATATCATCAACATGCTATTTTATCATGACAGGTTTAAAGTCTTTGCAGACTACGAAGCC TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATGAATCCAAAGGCCTGGAACACA ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA TCTAACAAAGTCAATGGAAATTGA PF00343 Phosphorylase function catalytic activity function vitamin binding function pyridoxal phosphate binding function transferase activity function transferase activity, transferring glycosyl groups function transferase activity, transferring hexosyl groups function phosphorylase activity function binding process metabolism process macromolecule metabolism process carbohydrate metabolism process physiological process "

owl:sameAs

drug:Guanosine-5'-Monophosphate

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