Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01677"

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rdfs:label
"Fumarate"
rdf:type
drugbank:drugs
drugbank:description
" 110-17-8 experimental Chung Kun Shih, Craig W. Gleason, Edmund H. Braun, II, "Solventless process for producing dialkyl fumarate-vinyl acetate copolymers." U.S. Patent US4772674, issued September, 1980. This compound belongs to the dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. Dicarboxylic Acids and Derivatives Organic Compounds Organic Acids and Derivatives Carboxylic Acids and Derivatives Dicarboxylic Acids and Derivatives Enones Polyamines Enolates Carboxylic Acid Salts enone polyamine enolate carboxylic acid salt Solution Respiratory (inhalation) logP -0.02 ALOGPS logS 0.14 ALOGPS Water Solubility 2.06e+02 g/l ALOGPS logP -0.041 ChemAxon IUPAC Name (2E)-but-2-enedioate ChemAxon Traditional IUPAC Name fumarate ChemAxon Molecular Weight 114.0563 ChemAxon Monoisotopic Weight 113.995308552 ChemAxon SMILES [O-]C(=O)\C=C\C([O-])=O ChemAxon Molecular Formula C4H2O4 ChemAxon InChI InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/p-2/b2-1+ ChemAxon InChIKey InChIKey=VZCYOOQTPOCHFL-OWOJBTEDSA-L ChemAxon Polar Surface Area (PSA) 80.26 ChemAxon Refractivity 46.28 ChemAxon Polarizability 8.65 ChemAxon Rotatable Bond Count 2 ChemAxon H Bond Acceptor Count 4 ChemAxon H Bond Donor Count 0 ChemAxon pKa (strongest acidic) 3.55 ChemAxon Physiological Charge -2 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five true ChemAxon Water Solubility 7000 mg/L (at 25 °C) US EPA (1981) Melting Point 287 dec °C PhysProp Boiling Point 522 °C PhysProp logP 0.46 HANSCH,C ET AL. (1995) pKa 3.03 (at 18 °C) LIDE,DR (1996) ChEBI 29806 PubChem Compound 5460307 PubChem Substance 46508303 KEGG Compound C00122 KEGG Drug D02308 ChemSpider 144248 BindingDB 26122 PDB FMR Wikipedia Fumarate RxList http://www.rxlist.com/cgi/generic/perforomist.htm SMP00549 2-ketoglutarate dehydrogenase complex deficiency DB00119 Pyruvic acid DB00121 Biotin DB00139 Succinic acid DB01677 Fumarate DB04272 Citric Acid P08559 P11177 P10515 P09622 O75390 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P07954 P40926 P11498 P31040 P21912 Q99643 O14521 Q9Y5U8 Q99798 SMP00369 Tyrosinemia Type 2 (or Richner-Hanhart syndrome) DB00120 L-Phenylalanine DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB01373 Calcium DB01592 Iron DB01677 Fumarate P17174 Q96RQ9 P17735 P00439 P54577 Q9Y285 Q9NSD9 P32754 Q93099 O43708 P16930 SMP00370 Tyrosinemia Type 3 (TYRO3) DB00120 L-Phenylalanine DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB01373 Calcium DB01592 Iron DB01677 Fumarate P17174 Q96RQ9 P17735 P00439 P54577 Q9Y285 Q9NSD9 P32754 Q93099 O43708 P16930 SMP00533 Monoamine oxidase-a deficiency (MAO-A) DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03205 Pyrroloquinoline Quinone P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P09172 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 SMP00057 Citric Acid Cycle DB00119 Pyruvic acid DB00121 Biotin DB00139 Succinic acid DB01677 Fumarate DB04272 Citric Acid P08559 P11177 P10515 P09622 O75390 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P07954 P40926 P11498 P31040 P21912 Q99643 O14521 Q9Y5U8 Q99798 SMP00546 Congenital lactic acidosis DB00119 Pyruvic acid DB00121 Biotin DB00139 Succinic acid DB01677 Fumarate DB04272 Citric Acid P08559 P11177 P10515 P09622 O75390 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P07954 P40926 P11498 P31040 P21912 Q99643 O14521 Q9Y5U8 Q99798 SMP00003 Argininosuccinic Aciduria DB00119 Pyruvic acid DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB00160 L-Alanine DB01373 Calcium DB01677 Fumarate DB03904 Urea Q15758 P43007 P24298 Q9UI32 P00367 P31327 P00505 P00480 Q9Y619 P05089 P04424 P00966 O75746 SMP00427 Azathioprine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB00993 Azathioprine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00430 Thioguanine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00352 Tioguanine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00428 Mercaptopurine Action Pathway DB00116 Tetrahydrofolic acid DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01033 Mercaptopurine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P00492 P20839 P49915 P51580 P63000 Q06278 Q06203 Q14542 Q9HAS3 Q99808 O43868 O15440 O15439 P47989 P55263 P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 Q9Y2T3 Q9UKK9 P21108 P22102 O15067 P22234 P30566 P31939 Q9BY32 P36959 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00429 Disulfiram Action Pathway DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00822 Disulfiram DB00898 Ethanol DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03166 Acetic acid DB03205 Pyrroloquinoline Quinone P09172 P30837 P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 P00325 P05091 P05181 P04040 Q9NR19 Q9NUB1 SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00144 Adenosine Deaminase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00167 Adenylosuccinate Lyase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00362 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00168 AICA-Ribosiduria DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00169 Alkaptonuria DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03205 Pyrroloquinoline Quinone P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P09172 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 SMP00507 L-arginine:glycine amidinotransferase deficiency DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00363 Ornithine Aminotransferase Deficiency (OAT Deficiency) DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00008 Phenylalanine and Tyrosine Metabolism DB00120 L-Phenylalanine DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB01373 Calcium DB01592 Iron DB01677 Fumarate P17174 Q96RQ9 P17735 P00439 P54577 Q9Y285 Q9NSD9 P32754 Q93099 O43708 P16930 SMP00020 Arginine and Proline Metabolism DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00357 Argininemia DB00119 Pyruvic acid DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB00160 L-Alanine DB01373 Calcium DB01677 Fumarate DB03904 Urea Q15758 P43007 P24298 Q9UI32 P00367 P31327 P00505 P00480 Q9Y619 P05089 P04424 P00966 O75746 SMP00067 Aspartate Metabolism DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB01593 Zinc DB01677 Fumarate DB03107 Beta-Alanine DB03166 Acetic acid P80404 Q99259 P08243 O43776 P00966 P14868 Q96RQ9 P30566 Q99489 P45381 Q8N142 P27708 Q7L266 P04424 SMP00505 Hyperornithinemia with gyrate atrophy (HOGA) DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00498 Dopamine beta-hydroxylase deficiency DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03205 Pyrroloquinoline Quinone P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P09172 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 SMP00175 Canavan Disease DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB01593 Zinc DB01677 Fumarate DB03107 Beta-Alanine DB03166 Acetic acid P80404 Q99259 P08243 O43776 P00966 P14868 Q96RQ9 P30566 Q99489 P45381 Q8N142 P27708 Q7L266 P04424 SMP00002 Carbamoyl Phosphate Synthetase Deficiency DB00119 Pyruvic acid DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB00160 L-Alanine DB01373 Calcium DB01677 Fumarate DB03904 Urea Q15758 P43007 P24298 Q9UI32 P00367 P31327 P00505 P00480 Q9Y619 P05089 P04424 P00966 O75746 SMP00355 Mitochondrial Electron Transport Chain DB00139 Succinic acid DB01677 Fumarate DB02263 Glyceraldehyde-3-Phosphate DB04326 1,3-Dihydroxyacetonephosphate O43826 P12235 Q06055 P25705 P56381 P06576 P24539 P30049 P36542 P00846 P43304 O15239 P31040 P21912 Q99643 O14521 P99999 P31930 A0S183 P21695 P04406 SMP00001 Citrullinemia Type I DB00119 Pyruvic acid DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB00160 L-Alanine DB01373 Calcium DB01677 Fumarate DB03904 Urea Q15758 P43007 P24298 Q9UI32 P00367 P31327 P00505 P00480 Q9Y619 P05089 P04424 P00966 O75746 SMP00203 Molybdenium Cofactor Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00548 Mitochondrial complex II deficiency DB00119 Pyruvic acid DB00121 Biotin DB00139 Succinic acid DB01677 Fumarate DB04272 Citric Acid P08559 P11177 P10515 P09622 O75390 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P07954 P40926 P11498 P31040 P21912 Q99643 O14521 Q9Y5U8 Q99798 SMP00504 Creatine deficiency, guanidinoacetate methyltransferase deficiency DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00059 Urea Cycle DB00119 Pyruvic acid DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB00160 L-Alanine DB01373 Calcium DB01677 Fumarate DB03904 Urea Q15758 P43007 P24298 Q9UI32 P00367 P31327 P00505 P00480 Q9Y619 P05089 P04424 P00966 O75746 SMP00537 Myoadenylate deaminase deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) DB00119 Pyruvic acid DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB00160 L-Alanine DB01373 Calcium DB01677 Fumarate DB03904 Urea Q15758 P43007 P24298 Q9UI32 P00367 P31327 P00505 P00480 Q9Y619 P05089 P04424 P00966 O75746 SMP00207 Prolidase Deficiency (PD) DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00550 Pyruvate dehydrogenase deficiency (E3) DB00119 Pyruvic acid DB00121 Biotin DB00139 Succinic acid DB01677 Fumarate DB04272 Citric Acid P08559 P11177 P10515 P09622 O75390 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P07954 P40926 P11498 P31040 P21912 Q99643 O14521 Q9Y5U8 Q99798 SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00210 Purine Nucleoside Phosphorylase Deficiency DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00551 Pyruvate dehydrogenase deficiency (E2) DB00119 Pyruvic acid DB00121 Biotin DB00139 Succinic acid DB01677 Fumarate DB04272 Citric Acid P08559 P11177 P10515 P09622 O75390 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P07954 P40926 P11498 P31040 P21912 Q99643 O14521 Q9Y5U8 Q99798 SMP00547 Fumarase deficiency DB00119 Pyruvic acid DB00121 Biotin DB00139 Succinic acid DB01677 Fumarate DB04272 Citric Acid P08559 P11177 P10515 P09622 O75390 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P07954 P40926 P11498 P31040 P21912 Q99643 O14521 Q9Y5U8 Q99798 SMP00536 Mitochondrial DNA depletion syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00654 Warburg Effect DB00119 Pyruvic acid DB00121 Biotin DB00130 L-Glutamine DB00139 Succinic acid DB00142 L-Glutamic Acid DB01345 Potassium DB01677 Fumarate DB01709 2-Phosphoglyceric Acid DB01819 Phosphoenolpyruvate DB02263 Glyceraldehyde-3-Phosphate DB04272 Citric Acid DB04326 1,3-Dihydroxyacetonephosphate P11168 P52789 P06744 P17858 P05062 P04406 P00558 P15259 P06733 P30613 Q9Y5U8 P11498 P08559 P11177 P10515 P09622 O75390 Q6ZMR3 P53985 Q99798 P50213 O43837 P51553 Q02218 P36957 P53597 Q96I99 P31040 P21912 Q99643 O14521 P07954 P40925 P00367 Q9UI32 Q15758 P37837 P29401 P49247 O95336 P11413 P52209 Q6LAP8 P21399 O75874 P14618 SMP00365 Gout or Kelley-Seegmiller Syndrome DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00190 Hawkinsinuria DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03205 Pyrroloquinoline Quinone P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P09172 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 SMP00506 Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome] DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00360 Hyperprolinemia Type II DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00361 Hyperprolinemia Type I DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00192 Hypoacetylaspartia DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00155 L-Citrulline DB01593 Zinc DB01677 Fumarate DB03107 Beta-Alanine DB03166 Acetic acid P80404 Q99259 P08243 O43776 P00966 P14868 Q96RQ9 P30566 Q99489 P45381 Q8N142 P27708 Q7L266 P04424 SMP00218 Tyrosinemia Type I DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03205 Pyrroloquinoline Quinone P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P09172 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 SMP00512 Xanthinuria type I DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00513 Xanthinuria type II DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00208 Prolinemia Type II DB00118 S-Adenosylmethionine DB00128 L-Aspartic Acid DB00129 L-Ornithine DB00139 Succinic acid DB00142 L-Glutamic Acid DB00145 Glycine DB00148 Creatine DB00155 L-Citrulline DB00172 L-Proline DB01677 Fumarate DB03247 Riboflavin Monophosphate DB03904 Urea P00966 P04424 P31327 P00367 P04181 P30038 O43272 Q96C36 P07814 Q7Z4N8 Q5T160 P50440 Q14353 P12277 P05089 P00480 Q9Y619 P14920 P17174 P29475 SMP00364 Lesch-Nyhan Syndrome (LNS) DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00006 Tyrosine Metabolism DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03205 Pyrroloquinoline Quinone P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P09172 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 SMP00050 Purine Metabolism DB00116 Tetrahydrofolic acid DB00128 L-Aspartic Acid DB00130 L-Glutamine DB00142 L-Glutamic Acid DB00145 Glycine DB00640 Adenosine DB01345 Potassium DB01373 Calcium DB01593 Zinc DB01677 Fumarate DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione DB01700 Aicar DB01972 Guanosine-5'-Monophosphate DB02134 Xanthine DB02377 Guanine DB02527 Cyclic Adenosine Monophosphate DB02857 Guanosine DB04076 Hypoxanthine DB04335 Inosine P50583 O75414 O75356 Q5MY95 Q16774 P49902 Q16854 P07741 P00491 P00492 Q9Y2T3 Q9UKK9 P21108 Q06203 P22102 O15067 P22234 P30566 P31939 Q9BY32 P49915 P20839 P36959 P47989 P30520 P23109 P00813 P00568 Q8NBU5 Q08499 Q96PN6 P33402 Q02153 Q9Y233 P10599 P23921 P31350 SMP00494 Tyrosinemia, transient, of the newborn DB00118 S-Adenosylmethionine DB00126 Vitamin C DB00128 L-Aspartic Acid DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB00368 Norepinephrine DB00988 Dopamine DB01235 L-DOPA DB01373 Calcium DB01592 Iron DB01593 Zinc DB01677 Fumarate DB01702 2-(3,4-Dihydroxyphenyl)Acetic Acid DB02232 1,2-Dihydroxybenzene DB03205 Pyrroloquinoline Quinone P17735 P17174 P32754 O43708 P16930 P20711 P30838 P14679 P09172 P40126 P11086 P21397 P07327 P46952 Q93099 P14174 P19801 P21964 SMP00206 Phenylketonuria DB00120 L-Phenylalanine DB00135 L-Tyrosine DB00142 L-Glutamic Acid DB01373 Calcium DB01592 Iron DB01677 Fumarate P17174 Q96RQ9 P17735 P00439 P54577 Q9Y285 Q9NSD9 P32754 Q93099 O43708 P16930 BE0001267 Malate dehydrogenase Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Malate dehydrogenase Energy production and conversion Catalyzes the reversible oxidation of malate to oxaloacetate mdh None 4.91 32717.0 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) GenBank Gene Database X89038 GenBank Protein Database 1491644 UniProtKB P80040 UniProt Accession MDH_CHLAA EC 1.1.1.37 >Malate dehydrogenase MRKKISIIGAGFVGSTTAHWLAAKELGDIVLLDIVEGVPQGKALDLYEASPIEGFDVRVT GTNNYADTANSDVIVVTSGAPRKPGMSREDLIKVNADITRACISQAAPLSPNAVIIMVNN PLDAMTYLAAEVSGFPKERVIGQAGVLDAARYRTFIAMEAGVSVEDVQAMLMGGHGDEMV PLPRFSTISGIPVSEFIAPDRLAQIVERTRKGGGEIVNLLKTGSAYYAPAAATAQMVEAV LKDKKRVMPVAAYLTGQYGLNDIYFGVPVILGAGGVEKILELPLNEEEMALLNASAKAVR ATLDTLKSL >930 bp ATGCGCAAGAAGATTAGTATTATCGGGGCAGGATTTGTCGGTTCGACGACAGCTCACTGG CTGGCCGCTAAAGAATTAGGTGACATTGTTCTGCTTGATATTGTCGAGGGTGTGCCTCAA GGCAAGGCTCTCGATCTCTACGAGGCATCACCAATTGAAGGGTTTGATGTTCGGGTGACC GGCACGAACAACTACGCCGATACTGCCAACTCGGATGTCATCGTTGTTACGTCAGGTGCT CCGCGCAAGCCGGGCATGAGCCGTGAGGATTTGATCAAGGTCAACGCCGACATCACCCGT GCCTGTATCAGTCAGGCTGCCCCGCTCTCGCCGAATGCCGTGATTATCATGGTCAATAAT CCTCTGGATGCGATGACCTATCTGGCGGCGGAGGTTAGTGGCTTCCCCAAAGAGCGTGTC ATTGGTCAGGCCGGCGTCCTCGATGCGGCCCGCTATCGCACCTTCATTGCCATGGAGGCG GGTGTTTCGGTTGAAGATGTTCAGGCGATGCTGATGGGTGGTCACGGCGATGAGATGGTA CCGCTGCCCCGGTTTTCAACCATTAGCGGTATTCCGGTGAGCGAGTTCATTGCGCCTGAT CGTCTGGCTCAGATTGTTGAGCGCACCCGGAAGGGTGGTGGCGAGATTGTGAATCTGCTG AAGACCGGCAGTGCGTATTATGCTCCCGCCGCCGCCACAGCGCAGATGGTCGAAGCGGTG CTCAAAGACAAGAAGCGGGTCATGCCGGTGGCAGCCTACCTGACCGGTCAGTACGGCCTG AATGATATTTACTTTGGTGTACCGGTGATCCTCGGTGCCGGTGGAGTAGAGAAAATTCTC GAATTGCCGCTCAACGAAGAGGAGATGGCACTGCTGAACGCATCGGCGAAAGCGGTACGT GCCACCCTCGACACGCTGAAGTCTCTCTAA PF02866 Ldh_1_C PF00056 Ldh_1_N function oxidoreductase activity function L-malate dehydrogenase activity function malate dehydrogenase activity function oxidoreductase activity, acting on CH-OH group of donors function lactate dehydrogenase activity function L-lactate dehydrogenase activity function catalytic activity process glucose metabolism process metabolism process glucose catabolism process cellular metabolism process glycolysis process generation of precursor metabolites and energy process malate metabolism process energy derivation by oxidation of organic compounds process tricarboxylic acid cycle intermediate metabolism process main pathways of carbohydrate metabolism process alcohol metabolism process monosaccharide metabolism process physiological process process hexose metabolism BE0002001 Fumarate reductase flavoprotein subunit Shewanella frigidimarina # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Fumarate reductase flavoprotein subunit Energy production and conversion Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron transfer from formate to fumarate and possibly also to trimethylamine oxide (TMAO). This enzyme is essentially unidirectional fccA Periplasm None 6.51 60622.0 Shewanella frigidimarina GenBank Gene Database AJ132010 GenBank Protein Database 4539587 UniProtKB P0C278 UniProt Accession FRDA_SHEFR EC 1.3.99.1 Fcc3 Flavocytochrome c Flavocytochrome c3 >Fumarate reductase flavoprotein subunit ADNLAEFHVQNQECDSCHTPDGELSNDSLTYENTQCVSCHGTLEEVAETTKHEHYNAHAS HFPGEVACTSCHSAHEKSMVYCDSCHSFDFNMPYAKKWQRDEPTIAELAKDKSERQAALA SAPHDTVDVVVVGSGGAGFSAAISATDSGAKVILIEKEPVIGGNAKLAAGGMNAAWTDQQ KAKKITDSPELMFEDTMKGGQNINDPALVKVLSSHSKDSVDWMTAMGADLTDVGMMGGAS VNRAHRPTGGAGVGAHVVQVLYDNAVKRNIDLRMNTRGIEVLKDDKGTVKGILVKGMYKG YYWVKADAVILATGGFAKNNERVAKLDPSLKGFISTNQPGAVGDGLDVAENAGGALKDMQ YIQAHPTLSVKGGVMVTEAVRGNGAILVNREGKRFVNEITTRDKASAAILAQTGKSAYLI FDDSVRKSLSKIDKYIGLGVAPTADSLVKLGKMEGIDGKALTETVARYNSLVSSGKDTDF ERPNLPRALNEGNYYAIEVTPGVHHTMGGVMIDTKAEVMNAKKQVIPGLYGAGEVTGGVH GANRLGGNAISDIITFGRLAGEEAAKYSKKN >1683 bp AACCAAGAATGTGATAGCTGCCATACACCAGATGGTGAACTGTCAAATGACAGCTTAACT TATGAAAATACACAATGTGTATCTTGCCATGGCACACTAGAGGAAGTCGCTGAAACGACA AAACATGAACACTATAATGCTCATGCTTCTCATTTCCCTGGCGAAGTAGCTTGTACCTCA TGCCACAGCGCACACGAAAAATCGATGGTGTATTGTGACTCTTGCCATAGCTTCGATTTC AACATGCCTTATGCTAAAAAATGGCAACGTGACGAGCCTACTATTGCTGAACTGGCCAAA GATAAATCAGAACGTCAGGCTGCTCTTGCTAGCGCACCTCACGATACTGTTGACGTAGTG GTTGTCGGTTCTGGCGGCGCAGGTTTCTCAGCAGCAATATCTGCAACAGACAGTGGTGCT AAAGTCATTCTTATTGAAAAAGAGCCTGTTATTGGTGGTAATGCTAAGTTAGCTGCGGGT GGCATGAACGCTGCTTGGACTGATCAACAAAAAGCCAAAAAAATTACTGACAGCCCAGAG TTAATGTTCGAAGACACCATGAAAGGTGGCCAAAACATAAATGATCCTGCATTAGTTAAA GTATTAAGCTCACACTCTAAAGACTCTGTTGATTGGATGACCGCTATGGGTGCCGATTTA ACTGATGTTGGCATGATGGGTGGCGCATCTGTTAATCGTGCGCATCGTCCAACCGGTGGT GCTGGTGTAGGTGCTCATGTTGTTCAAGTACTTTATGATAATGCAGTGAAACGCAATATC GACTTACGCATGAACACTCGCGGCATTGAAGTGCTTAAAGATGATAAAGGCACTGTTAAA GGTATTCTGGTTAAGGGTATGTATAAAGGTTACTACTGGGTGAAAGCCGATGCGGTAATC TTAGCAACGGGTGGTTTCGCTAAAAATAACGAGCGTGTCGCTAAGCTTGATCCTTCACTA AAAGGCTTTATCTCTACTAACCAACCTGGTGCAGTAGGTGATGGACTGGATGTAGCGGAA AATGCGGGCGGCGCATTGAAAGACATGCAGTATATCCAAGCTCACCCAACACTATCTGTT AAAGGTGGCGTAATGGTCACTGAAGCGGTTCGTGGTAATGGTGCGATTTTGGTTAACCGT GAAGGTAAGCGTTTCGTTAACGAAATTACTACTCGTGATAAAGCATCTGCCGCTATCTTA GCGCAAACCGGTAAATCAGCTTATTTGATTTTTGATGATTCTGTGCGTAAGTCACTGTCA AAAATTGATAAGTATATTGGTTTAGGTGTTGCACCAACCGCAGATAGCCTAGTTAAATTA GGTAAAATGGAAGGTATTGACGGCAAAGCATTGACTGAAACTGTCGCGCGTTACAACAGC TTAGTGAGTAGCGGTAAAGACACTGATTTTGAGCGTCCAAACCTACCGCGCGCACTTAAC GAAGGTAACTACTATGCAATTGAAGTTACACCTGGTGTTCACCACACTATGGGTGGCGTG ATGATCGACACTAAAGCTGAAGTCATGAATGCTAAGAAGCAGGTTATCCCTGGCTTGTAT GGTGCTGGTGAGGTTACTGGCGGTGTTCATGGTGCTAACCGCTTAGGTGGTAATGCTATT TCAGACATCATCACCTTCGGTCGCTTAGCGGGTGAAGAAGCTGCAAAATATTCTAAAAAG AAC PF00890 FAD_binding_2 function catalytic activity function oxidoreductase activity function oxidoreductase activity, acting on the CH-CH group of donors function succinate dehydrogenase activity process physiological process process metabolism process cellular metabolism process generation of precursor metabolites and energy process electron transport BE0001487 Fumarate reductase flavoprotein subunit Shewanella oneidensis (strain MR-1) # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown Fumarate reductase flavoprotein subunit Energy production and conversion Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron transfer from formate to fumarate and possibly also to trimethylamine oxide (TMAO). This enzyme is essentially unidirectional SO_0970 Periplasm None 7.64 62448.0 Shewanella oneidensis (strain MR-1) GenBank Gene Database AE014299 GenBank Protein Database 24346572 UniProtKB P83223 UniProt Accession FRDA_SHEON EC 1.3.99.1 FL cyt Flavocytochrome c Fumarate reductase flavoprotein subunit precursor >Fumarate reductase flavoprotein subunit precursor MFTRKIQKTALAMLISGAMAGTAYAAPEVLADFHGEMGGCDSCHVSDKGGVTNDNLTHEN GQCVSCHGDLKELAAAAPKDKVSPHKSHLIGEIACTSCHKGHEKSVAYCDACHSFGFDMP FGGKWERKFVPVDADKAAQDKAIAAGVKETTDVVIIGSGGAGLAAAVSARDAGAKVILLE KEPIPGGNTKLAAGGMNAAETKPQAKLGIEDKKQIMIDDTMKGGRNINDPELVKVLANNS SDSIDWLTSMGADMTDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDNAVKRGTDIRLNS RVVRILEDASGKVTGVLVKGEYTGYYVIKADAVVIAAGGFAKNNERVSKYDPKLKGFKAT NHPGATGDGLDVALQAGAATRDLEYIQAHPTYSPAGGVMITEAVRGNGAIVVNREGNRFM NEITTRDKASAAILQQKGESAYLVFDDSIRKSLKAIEGYVHLNIVKEGKTIEELAKQIDV PAAELAKTVTAYNGFVKSGKDAQFERPDLPRELVVAPFYALEIAPAVHHTMGGLVIDTKA EVKSEKTGKPITGLYAAGEVTGGVHGANRLGGNAISDIVTYGRIAGASAAKFAKDN >1791 bp TTAATTATCTTTAGCGAATTTAGCGGCAGATGCACCCGCGATACGGCCGTAGGTGACGAT ATCAGAGATAGCGTTACCACCTAAACGGTTAGCACCGTGAACACCACCAGTCACTTCGCC TGCAGCGTATAAACCAGTGATAGGTTTACCGGTTTTCTCACTCTTCACTTCGGCTTTAGT ATCAATCACCAGACCACCCATAGTGTGGTGAACCGCTGGTGCAATTTCTAAGGCGTAGAA AGGAGCTACCACTAATTCACGTGGTAAATCAGGACGTTCAAATTGAGCATCTTTACCTGA TTTAACGAAACCGTTGTAGGCTGTTACTGTTTTTGCCAATTCAGCTGCAGGTACATCGAT TTGTTTCGCTAACTCTTCGATGGTTTTACCTTCTTTTACAATGTTCAGGTGAACATAACC TTCGATGGCCTTCAAGCTCTTACGGATAGAGTCATCGAATACTAGGTAAGCGCTTTCACC TTTTTGTTGCAGAATCGCCGCAGACGCTTTATCACGGGTGGTGATTTCGTTCATAAAACG ATTACCTTCACGGTTCACCACGATTGCACCGTTACCACGTACTGCCTCGGTGATCATCAC GCCACCCGCTGGAGAGTAAGTTGGGTGAGCTTGGATGTATTCTAAGTCACGTGTTGCTGC GCCCGCTTGTAGAGCTACGTCTAAGCCGTCACCCGTCGCACCTGGGTGGTTGGTCGCTTT AAAGCCTTTTAACTTAGGATCGTATTTAGAAACACGTTCGTTGTTTTTCGCAAAACCACC TGCTGCAATGACTACTGCATCGGCTTTGATCACATAGTAACCTGTGTATTCACCTTTCAC TAAAACGCCGGTCACTTTACCGCTTGCATCTTCAAGGATGCGCACAACGCGGCTGTTTAA GCGAATATCAGTACCACGCTTAACGGCGTTGTCCCACAGCACTTGTGCTACGTGAGCACC AACACCTGCACCACCGGTTGGACGGTGACTACGGTTAACGCTCGCGCCACCCATACGACC CACGTCAGTCATGTCGGCACCCATAGAGGTTAACCAATCGATTGAGTCTGAAGAGTTGTT AGCCAGTACTTTAACTAATTCAGGATCGTTGATGTTGCGGCCACCTTTCATAGTGTCGTC GATCATGATTTGTTTCTTATCTTCGATACCTAACTTAGCCTGTGGCTTAGTTTCTGCGGC GTTCATACCACCGGCAGCCAGTTTAGTGTTACCACCTGGGATAGGTTCTTTTTCTAACAG AATCACTTTCGCGCCAGCATCACGGGCAGATACGGCAGCGGCAAGACCAGCACCACCAGA GCCGATAATTACAACGTCTGTGGTTTCTTTCACACCAGCAGCAATGGCTTTATCTTGTGC TGCTTTGTCTGCATCAACAGGTACAAACTTACGTTCCCACTTGCCACCAAATGGCATATC GAAGCCGAAGCTATGGCAAGCATCACAATAAGCTACTGATTTTTCGTGGCCTTTGTGGCA GCTCGTACAAGCGATTTCACCAATTAAGTGAGATTTGTGCGGAGAAACTTTATCTTTAGG CGCTGCTGCAGCCAGTTCTTTTAAGTCACCGTGGCAGCTAACACATTGGCCATTCTCATG GGTCAGGTTGTCGTTAGTCACGCCACCTTTGTCTGATACGTGGCAGCTATCGCAGCCACC CATTTCACCGTGAAAATCGGCTAGTACTTCTGGAGCGGCATAGGCTGTGCCTGCCATTGC GCCAGAGATCAGCATGGCTAGTGCTGTTTTTTGAATCTTTCTTGTGAACAT PF00890 FAD_binding_2 function oxidoreductase activity, acting on the CH-CH group of donors function succinate dehydrogenase activity function catalytic activity function oxidoreductase activity process electron transport process physiological process process metabolism process cellular metabolism process generation of precursor metabolites and energy BE0000148 NAD-dependent malic enzyme, mitochondrial Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 unknown NAD-dependent malic enzyme, mitochondrial Energy production and conversion ME2 6p25-p24|18q21 Mitochondrion; mitochondrial matrix None 7.67 65444.0 Human HUGO Gene Nomenclature Committee (HGNC) HGNC:6984 GenAtlas ME2 GeneCards ME2 GenBank Gene Database M55905 GenBank Protein Database 187300 UniProtKB P23368 UniProt Accession MAOM_HUMAN EC 1.1.1.38 Malic enzyme 2 NAD-dependent malic enzyme, mitochondrial precursor NAD-ME >NAD-dependent malic enzyme, mitochondrial precursor MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIET QDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLAC SQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMK AITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISK PISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALS NPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVIL CNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMA FRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE >1755 bp ATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCAC ATAAAAGAAAAAGGCAAGCCACTTATGCTGAACCCAAGAACAAACAAGGGAATGGCATTT ACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGACA CAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAA AAATATATCTACATAATGGGAATACAAGAAAGAAATGAGAAATTGTTTTATAGAATACTG CAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCTGC TCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGA GGTCATGTTAGATCAATTGTGGATAACTGGCCAGAAAATCATGTTAAGGCTGTTGTAGTG ACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTCCA GTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCA GTGTGTATTGATGTGGGAACTGATAATATCGCACTCTTAAAAGACCCATTTTACATGGGC TTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGAAA GCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCAT AATGCATTCAGGTTCTTGAGAAAGTACCGAGAAAAATATTGTACTTTCAATGATGATATT CAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTAAA CCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCA AATCTTATAGTTATGTCTATGGTAGAAAATGGCCTGTCAGAACAAGAGGCACAAAAGAAA ATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATAGT TATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCA GTGAATATACTGAAGCCTTCAACTATTATTGGAGTTGCAGGTGCTGGCCGTCTTTTCACT CCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAAGT AATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGG TGTTTGTTTGCCAGTGGCAGTCCATTTGGGCCAGTGAAACTTACAGATGGGCGAGTCTTT ACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTCTC TGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGC CAATTGACAGATGAAGAGCTAGCCCAAGGGAGACTTTACCCACCGCTTGCTAATATTCAG GAAGTTTCTATTAACATTGCTATTAAAGTTACAGAATACCTATATGCTAATAAAATGGCT TTCCGATACCCAGAACCTGAAGACAAGGCCAAATATGTTAAAGAAAGAACATGGCGGAGT GAATATGATTCCCTGCTGCCAGATGTGTATGAATGGCCAGAATCTGCATCAAGCCCTCCT GTGATAACAGAATAG PF00390 malic PF03949 Malic_M function catalytic activity function malate dehydrogenase activity function oxidoreductase activity function NAD binding function malic enzyme activity function cofactor binding function coenzyme binding function oxidoreductase activity, acting on CH-OH group of donors function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor function binding process main pathways of carbohydrate metabolism process metabolism process malate metabolism process cellular metabolism process tricarboxylic acid cycle intermediate metabolism process generation of precursor metabolites and energy process energy derivation by oxidation of organic compounds process physiological process BE0004531 Fumarylacetoacetase Human # Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284 # Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423 # Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10592235 unknown Fumarylacetoacetase FAH Human UniProtKB P16930 UniProt Accession FAAA_HUMAN "
owl:sameAs
drug:Tetrahydrofolic acid
drug:S-Adenosylmethionine
drug:Pyruvic acid
drug:L-Phenylalanine
drug:Biotin
drug:Vitamin C
drug:L-Aspartic Acid
drug:L-Ornithine
drug:L-Glutamine
drug:L-Tyrosine
drug:Succinic acid
drug:L-Glutamic Acid
drug:Glycine
drug:Creatine
drug:L-Citrulline
drug:L-Alanine
drug:L-Proline
drug:Tioguanine
drug:Norepinephrine
drug:Adenosine
drug:Disulfiram
drug:Ethanol
drug:Dopamine
drug:Azathioprine
drug:Mercaptopurine
drug:L-DOPA
drug:Potassium
drug:Calcium
drug:Iron
drug:Zinc
drug:Fumarate
drug:7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione
drug:Aicar
drug:2-(3,4-Dihydroxyphenyl)Acetic Acid
drug:2-Phosphoglyceric Acid
drug:Phosphoenolpyruvate
drug:Guanosine-5'-Monophosphate
drug:Xanthine
drug:1,2-Dihydroxybenzene
drug:Glyceraldehyde-3-Phosphate
drug:Guanine
drug:Cyclic Adenosine Monophosphate
drug:Guanosine
drug:Beta-Alanine
drug:Acetic acid
drug:Pyrroloquinoline Quinone
drug:Riboflavin Monophosphate
drug:Urea
drug:Hypoxanthine
drug:Citric Acid
drug:1,3-Dihydroxyacetonephosphate
drug:Inosine
drug:EXPT01460
drug:EXPT01511

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 52 triples

Context graph