Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB01023"

Predicate	Value (sorted: default)
rdfs:label	"Felodipine"
rdf:type	drugbank:drugs
drugbank:description	"Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension. "
drugbank:drugCategory	drugcategory:Anti-Arrhythmia Agents drugcategory:Antihypertensive Agents drugcategory:Calcium Channel Blockers drugcategory:Dihydropyridines drugcategory:Vasodilator Agents
drugbank:interactsWith	drug:Erythromycin drug:Nelfinavir drug:Butabarbital drug:Butalbital drug:Phenytoin drug:Talbutal drug:Pentobarbital drug:Treprostinil drug:Secobarbital drug:Methohexital drug:Mephenytoin drug:Carbamazepine drug:Voriconazole drug:Thiopental drug:Ethotoin drug:Tretinoin drug:Oxcarbazepine drug:Primidone drug:Methylphenobarbital drug:Tacrolimus drug:Tipranavir drug:Telithromycin drug:Itraconazole drug:Phenobarbital drug:Fosphenytoin drug:Josamycin drug:Dihydroquinidine barbiturate drug:Quinidine barbiturate drug:Amobarbital drug:Aprobarbital drug:Butethal drug:Heptabarbital drug:Hexobarbital drug:Quinupristin
owl:sameAs	drug:APRD00374 drug:BE0002638 drug:Erythromycin drug:Nelfinavir drug:Butabarbital drug:Butalbital drug:Phenytoin drug:Talbutal drug:Pentobarbital drug:Treprostinil drug:Secobarbital drug:Methohexital drug:Mephenytoin drug:Carbamazepine drug:Voriconazole drug:Thiopental drug:Ethotoin drug:Tretinoin drug:Oxcarbazepine drug:Primidone drug:Methylphenobarbital drug:Tacrolimus drug:Tipranavir drug:Telithromycin drug:Felodipine drug:Itraconazole drug:Phenobarbital drug:Fosphenytoin drug:Josamycin drug:Dihydroquinidine barbiturate drug:Potassium drug:Quinidine barbiturate drug:Amobarbital drug:Aprobarbital drug:Butethal drug:Heptabarbital drug:Hexobarbital drug:Quinupristin drug:Calcium drug:DBMET00368

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 71 triples

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