Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00912"

Predicate	Value (sorted: default)
rdfs:label	"Repaglinide"
rdf:type	drugbank:drugs
drugbank:description	"Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine. "
drugbank:drugCategory	drugcategory:Antidiabetic Agents drugcategory:Hypoglycemic Agents drugcategory:Meglitinides
drugbank:interactsWith	drug:Cyclosporine drug:Pravastatin drug:Esmolol drug:Betaxolol drug:Erythromycin drug:Metoprolol drug:Atenolol drug:Timolol drug:Sotalol drug:Carteolol drug:Propranolol drug:Voriconazole drug:Labetalol drug:Bisoprolol drug:Pindolol drug:Telithromycin drug:Rifampicin drug:Fluvastatin drug:Carvedilol drug:Acebutolol drug:Nadolol drug:Clarithromycin drug:Gemfibrozil drug:Bevantolol drug:Glucosamine drug:Practolol drug:Josamycin drug:Penbutolol drug:Oxprenolol
owl:sameAs	drug:APRD00439 drug:BE0002638 drug:BE0002887 drug:Cyclosporine drug:Pravastatin drug:Esmolol drug:Betaxolol drug:Erythromycin drug:Metoprolol drug:Atenolol drug:Timolol drug:Sotalol drug:Carteolol drug:Propranolol drug:Voriconazole drug:Labetalol drug:Bisoprolol drug:Repaglinide drug:Pindolol drug:Telithromycin drug:Rifampicin drug:Fluvastatin drug:Carvedilol drug:Acebutolol drug:Nadolol drug:Clarithromycin drug:Gemfibrozil drug:Bevantolol drug:Glucosamine drug:Practolol drug:Josamycin drug:Potassium drug:Penbutolol drug:Calcium drug:Oxprenolol drug:DBMET00294 drug:DBMET00338

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 61 triples

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