Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00864"

Predicate	Value (sorted: default)
rdfs:label	"Tacrolimus"
rdf:type	drugbank:drugs
drugbank:description	"Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription."
drugbank:interactsWith	drug:Trastuzumab drug:Cyclosporine drug:Octreotide drug:Abarelix drug:Natalizumab drug:Fluconazole drug:Erythromycin drug:Dofetilide drug:Moxifloxacin drug:Nelfinavir drug:Indinavir drug:Cladribine drug:Ranolazine drug:Ziprasidone drug:Phenytoin drug:Clotrimazole drug:Carmustine drug:Isradipine drug:Disopyramide drug:Bleomycin drug:Chlorambucil drug:Ibutilide drug:Amitriptyline drug:Methadone drug:Omeprazole drug:Diltiazem drug:Protriptyline drug:Mefloquine drug:Loxapine drug:Chloramphenicol drug:Droperidol drug:Imipramine drug:Fluoxetine drug:Chlorpromazine drug:Amikacin drug:Sotalol drug:Cimetidine drug:Haloperidol drug:Ritonavir drug:Cisplatin drug:Caspofungin drug:Foscarnet drug:Toremifene drug:Nortriptyline drug:Amoxapine drug:Perflutren drug:Carbamazepine drug:Voriconazole drug:Cisapride drug:Rifabutin drug:Imatinib drug:Nicardipine drug:Clofarabine drug:Verapamil drug:Thioridazine drug:Amphotericin B drug:Tobramycin drug:Mycophenolate mofetil drug:Amprenavir drug:Delavirdine drug:Apomorphine drug:Trimipramine drug:Risperidone drug:Pentamidine drug:Dolasetron drug:Gentamicin drug:Indapamide drug:Conivaptan drug:Flupentixol drug:Sirolimus drug:Quinidine drug:Metronidazole drug:Tipranavir drug:Mesoridazine drug:Maprotiline drug:Isoniazid drug:Netilmicin drug:Carboplatin drug:Methylprednisolone drug:Telithromycin drug:Ethinyl Estradiol drug:Neomycin drug:Felodipine drug:Ketoconazole drug:Topotecan drug:Procainamide drug:Gatifloxacin drug:Rifampicin drug:Norfloxacin drug:Atazanavir drug:Streptomycin drug:Pimozide drug:Miconazole drug:Nifedipine drug:Amiodarone drug:Levofloxacin drug:Doxepin drug:Nefazodone drug:Desipramine drug:Itraconazole drug:Arsenic trioxide drug:Phenobarbital drug:Propafenone drug:Domperidone drug:Flecainide drug:Bromocriptine drug:Sparfloxacin drug:Clarithromycin drug:Halofantrine drug:Quetiapine drug:Paclitaxel drug:Saquinavir drug:Metoclopramide drug:Clomipramine drug:Dasatinib drug:Lapatinib drug:Posaconazole drug:Darunavir drug:Sunitinib drug:Fosamprenavir drug:Fosphenytoin drug:St. John's Wort drug:Troleandomycin drug:Quinupristin drug:Mibefradil drug:Danazol drug:Probucol drug:Lopinavir drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Apramycin drug:Tetrabenazine drug:Dronedarone drug:Homoharringtonine drug:Nilotinib drug:Telaprevir drug:ado-trastuzumab emtansine drug:Silodosin drug:Temsirolimus drug:Rilonacept drug:golimumab drug:Artemether drug:Lumefantrine drug:Crizotinib drug:Brentuximab vedotin drug:Boceprevir drug:Teriflunomide drug:Tofacitinib drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00276 drug:BE0002638 drug:Trastuzumab drug:Cyclosporine drug:Octreotide drug:Abarelix drug:Natalizumab drug:Fluconazole drug:Erythromycin drug:Dofetilide drug:Moxifloxacin drug:Nelfinavir drug:Indinavir drug:Cladribine drug:Ranolazine drug:Ziprasidone drug:Phenytoin drug:Clotrimazole drug:Carmustine drug:Isradipine drug:Disopyramide drug:Bleomycin drug:Chlorambucil drug:Ibutilide drug:Amitriptyline drug:Methadone drug:Omeprazole drug:Diltiazem drug:Protriptyline drug:Mefloquine drug:Loxapine drug:Chloramphenicol drug:Droperidol drug:Imipramine drug:Fluoxetine drug:Chlorpromazine drug:Amikacin drug:Sotalol drug:Cimetidine drug:Haloperidol drug:Ritonavir drug:Cisplatin drug:Caspofungin drug:Foscarnet drug:Toremifene drug:Nortriptyline drug:Amoxapine drug:Perflutren drug:Carbamazepine drug:Voriconazole drug:Cisapride drug:Rifabutin drug:Imatinib drug:Nicardipine drug:Clofarabine drug:Verapamil drug:Thioridazine drug:Amphotericin B drug:Tobramycin drug:Mycophenolate mofetil drug:Amprenavir drug:Delavirdine drug:Apomorphine drug:Trimipramine drug:Risperidone drug:Pentamidine drug:Dolasetron drug:Gentamicin drug:Indapamide drug:Tacrolimus drug:Conivaptan drug:Flupentixol drug:Sirolimus drug:Quinidine drug:Metronidazole drug:Tipranavir drug:Mesoridazine drug:Maprotiline drug:Isoniazid drug:Netilmicin drug:Carboplatin drug:Methylprednisolone drug:Telithromycin drug:Ethinyl Estradiol drug:Neomycin drug:Felodipine drug:Ketoconazole drug:Topotecan drug:Procainamide drug:Gatifloxacin drug:Rifampicin drug:Norfloxacin drug:Atazanavir drug:Streptomycin drug:Pimozide drug:Miconazole drug:Nifedipine drug:Amiodarone drug:Levofloxacin drug:Doxepin drug:Nefazodone drug:Desipramine drug:Itraconazole drug:Arsenic trioxide drug:Phenobarbital drug:Propafenone drug:Domperidone drug:Flecainide drug:Bromocriptine drug:Sparfloxacin drug:Clarithromycin drug:Halofantrine drug:Quetiapine drug:Paclitaxel drug:Saquinavir drug:Metoclopramide drug:Clomipramine drug:Dasatinib drug:Lapatinib drug:Posaconazole drug:Darunavir drug:Sunitinib drug:Fosamprenavir drug:Fosphenytoin drug:St. John's Wort drug:Troleandomycin drug:Quinupristin drug:Mibefradil drug:Danazol drug:Probucol drug:Lopinavir drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Apramycin drug:Tetrabenazine drug:Dronedarone drug:Homoharringtonine drug:Nilotinib drug:Telaprevir drug:ado-trastuzumab emtansine drug:Silodosin drug:Temsirolimus drug:Rilonacept drug:golimumab drug:Artemether drug:Lumefantrine drug:Crizotinib drug:Brentuximab vedotin drug:Boceprevir drug:Teriflunomide drug:Tofacitinib drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate drug:DBMET00390 drug:DBMET00670 drug:DBSALT000167 drug:EXPT01437

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 303 triples

Context graph