Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00672"

Predicate	Value (sorted: default)
rdfs:label	"Chlorpropamide"
rdf:type	drugbank:drugs
drugbank:description	"Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS-33). Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites. Renal and hepatic dysfunction may increase the risk of hypoglycemia. "
drugbank:drugCategory	drugcategory:Antidiabetic Agents drugcategory:Hypoglycemic Agents
drugbank:interactsWith	drug:Somatropin recombinant drug:Esmolol drug:Betaxolol drug:Sulfisoxazole drug:Metoprolol drug:Dicoumarol drug:Atenolol drug:Sulfadiazine drug:Timolol drug:Chloramphenicol drug:Sotalol drug:Carteolol drug:Propranolol drug:Sulfamethizole drug:Voriconazole drug:Labetalol drug:Bisoprolol drug:Clofibrate drug:Sulfasalazine drug:Phenylbutazone drug:Sulfapyridine drug:Acetylsalicylic acid drug:Pindolol drug:Sulfamethoxazole drug:Rifampicin drug:Diazoxide drug:Carvedilol drug:Acebutolol drug:Nadolol drug:Bevantolol drug:Glucosamine drug:Practolol drug:Sulfacytine drug:Sulfadoxine drug:Penbutolol drug:Salsalate drug:Trisalicylate-choline drug:Oxprenolol drug:Sulfamerazine drug:Sulfamethazine
owl:sameAs	drug:APRD00029 drug:BE0002793 drug:BE0003536 drug:Somatropin recombinant drug:Esmolol drug:Betaxolol drug:Sulfisoxazole drug:Metoprolol drug:Dicoumarol drug:Atenolol drug:Sulfadiazine drug:Timolol drug:Chloramphenicol drug:Sotalol drug:Carteolol drug:Propranolol drug:Sulfamethizole drug:Voriconazole drug:Labetalol drug:Bisoprolol drug:Clofibrate drug:Chlorpropamide drug:Sulfasalazine drug:Phenylbutazone drug:Sulfapyridine drug:Acetylsalicylic acid drug:Pindolol drug:Sulfamethoxazole drug:Rifampicin drug:Diazoxide drug:Carvedilol drug:Acebutolol drug:Nadolol drug:Bevantolol drug:Glucosamine drug:Practolol drug:Sulfacytine drug:Sulfadoxine drug:Penbutolol drug:Salsalate drug:Trisalicylate-choline drug:Oxprenolol drug:Sulfamerazine drug:Sulfamethazine drug:DBMET00199 drug:DBMET00200 drug:DBMET00201 drug:DBMET00977

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 81 triples

Context graph