Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00605"

Predicate	Value (sorted: default)
rdfs:label	"Sulindac"
rdf:type	drugbank:drugs
drugbank:description	"Sulindac is a nonsteroidal anti-inflammatory agent (NSAIA) of the arylalkanoic acid class that is marketed in the U.S. by Merck as Clinoril. Like other NSAIAs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo to an active sulfide compound by liver enzymes. The sulfide metabolite then undergoes enterohepatic circulation; it is excreted in the bile and then reabsorbed from the intestine. This is thought to help maintain constant blood levels with reduced gastrointestinal side effects. Some studies have shown sulindac to be relatively less irritating to the stomach than other NSAIA's except for drugs of the cyclooxygenase-2 (COX-2) inhibitor class. The exact mechanism of its NSAIA properties is unknown, but it is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis."
drugbank:drugCategory	drugcategory:Anti-Inflammatory Agents, Non-Steroidal
drugbank:interactsWith	drug:Cyclosporine drug:S-Adenosylmethionine drug:Aminosalicylic Acid drug:Timolol drug:Treprostinil drug:Colestipol drug:Ketorolac drug:Trandolapril drug:Methotrexate drug:Pemetrexed drug:Warfarin drug:Furosemide drug:Bumetanide drug:Ethacrynic acid drug:Colesevelam drug:Acetylsalicylic acid drug:Telmisartan drug:Ginkgo biloba drug:Salicylate-sodium drug:Salsalate drug:Ginseng drug:Acenocoumarol drug:Cholestyramine drug:Pralatrexate drug:Azilsartan medoxomil
owl:sameAs	drug:APRD01243 drug:Cyclosporine drug:S-Adenosylmethionine drug:L-Glutamic Acid drug:Glutathione drug:Aminosalicylic Acid drug:Timolol drug:Treprostinil drug:Colestipol drug:Ketorolac drug:Trandolapril drug:Methotrexate drug:Sulindac drug:Pemetrexed drug:Warfarin drug:Furosemide drug:Bumetanide drug:Ethacrynic acid drug:Colesevelam drug:Acetylsalicylic acid drug:Telmisartan drug:Calcium drug:Ginkgo biloba drug:Salicylate-sodium drug:Salsalate drug:Ginseng drug:Acenocoumarol drug:Cholestyramine drug:Zinc drug:Arachidonic Acid drug:Pralatrexate drug:Azilsartan medoxomil drug:DBMET01002 drug:DBMET01003

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 56 triples

Context graph