Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00543"

Predicate	Value (sorted: default)
rdfs:label	"Amoxapine"
rdf:type	drugbank:drugs
drugbank:description	"Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation. "
drugbank:drugCategory	drugcategory:Adrenergic Uptake Inhibitors drugcategory:Antidepressive Agents, Second-Generation drugcategory:Dopamine Antagonists drugcategory:Neurotransmitter Uptake Inhibitors drugcategory:Serotonin Uptake Inhibitors
drugbank:interactsWith	drug:Fluvoxamine drug:Tramadol drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Methoxamine drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00142 drug:Fluvoxamine drug:Tramadol drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Amoxapine drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Methoxamine drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate drug:DBMET00775 drug:DBMET00776

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 133 triples

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