Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00540"

Predicate	Value (sorted: default)
rdfs:label	"Nortriptyline"
rdf:type	drugbank:drugs
drugbank:description	"Nortriptyline hydrochloride, the <i>N</i>-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Nortriptyline exerts less anticholinergic and sedative side effects compared to the tertiary amine TCAs, amitriptyline and clomipramine. Nortriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use). "
drugbank:drugCategory	drugcategory:Adrenergic Uptake Inhibitors drugcategory:Antidepressive Agents drugcategory:Antidepressive Agents, Tricyclic
drugbank:interactsWith	drug:Fluvoxamine drug:Tramadol drug:Fluconazole drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Duloxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Carbamazepine drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Methoxamine drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Ketoconazole drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Dihydroquinidine barbiturate drug:Quinidine barbiturate drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Vilazodone drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate
owl:sameAs	drug:APRD00602 drug:BE0000017 drug:BE0002363 drug:BE0002433 drug:BE0002638 drug:BE0003536 drug:Fluvoxamine drug:Tramadol drug:Fluconazole drug:Trospium drug:Butabarbital drug:Butalbital drug:Ziprasidone drug:Venlafaxine drug:Zolmitriptan drug:Terfenadine drug:Grepafloxacin drug:Norepinephrine drug:Tacrine drug:Phenylephrine drug:Phenylpropanolamine drug:Triprolidine drug:Fluoxetine drug:Duloxetine drug:Altretamine drug:Cimetidine drug:Ritonavir drug:Toremifene drug:Nortriptyline drug:Carbamazepine drug:Clonidine drug:Voriconazole drug:Cisapride drug:Metaraminol drug:Rifabutin drug:Trazodone drug:Trimethobenzamide drug:Epinephrine drug:Galantamine drug:Methoxamine drug:Trimipramine drug:Tranylcypromine drug:Phenelzine drug:Orciprenaline drug:Dobutamine drug:Donepezil drug:Pseudoephedrine drug:Terbinafine drug:Tacrolimus drug:Terbutaline drug:Quinidine drug:Dopamine drug:Rivastigmine drug:Salbutamol drug:Ketoconazole drug:Rifampicin drug:Isoprenaline drug:Atazanavir drug:Sibutramine drug:Guanethidine drug:Moclobemide drug:Sparfloxacin drug:Isocarboxazid drug:Fenoterol drug:Pirbuterol drug:Dihydroquinidine barbiturate drug:Quinidine barbiturate drug:Ephedra drug:Ephedrine drug:Mephentermine drug:Procaterol drug:Rasagiline drug:Thiothixene drug:Zuclopenthixol drug:Vorinostat drug:Vilazodone drug:Artemether drug:Desvenlafaxine drug:Lumefantrine drug:Zuclopenthixol acetate drug:Zuclopenthixol decanoate drug:DBMET00052 drug:DBMET00053 drug:DBMET00482 drug:DBSALT000641

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 149 triples

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