Local view for "http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugs/DB00227"

Predicate	Value (sorted: default)
rdfs:label	"Lovastatin"
rdf:type	drugbank:drugs
drugbank:description	"Lovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. It was the second agent of this class discovered. It was discovered by Alfred Alberts and his team at Merck in 1978 after screening only 18 compounds over 2 weeks. The agent, also known as mevinolin, was isolated from the fungi <i>Aspergillus terreus</i>. Research on this compound was suddenly shut down in 1980 and the drug was not approved until 1987. Interesting, Akira Endo at Sankyo Co. (Japan) patented lovastatin isolated from <i>Monascus ruber</i> four months before Merck. Lovastatin was found to be 2 times more potent than its predecessor, mevastatin, the first discovered statin. Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at the 6’ position. Lovastatin is a prodrug that is activated by <i>in vivo</i> hydrolysis of the lactone ring. It, along with mevastatin, has served as one of the lead compounds for the development of the synthetic compounds used today."
drugbank:drugCategory	drugcategory:Anticholesteremic Agents drugcategory:Hydroxymethylglutaryl-CoA Reductase Inhibitors
drugbank:interactsWith	drug:Cyclosporine drug:Fluconazole drug:Erythromycin drug:Azithromycin drug:Nelfinavir drug:Indinavir drug:Nevirapine drug:Dicoumarol drug:Diltiazem drug:Ritonavir drug:Bosentan drug:Carbamazepine drug:Voriconazole drug:Rifabutin drug:Imatinib drug:Efavirenz drug:Niacin drug:Verapamil drug:Warfarin drug:Amprenavir drug:Delavirdine drug:Tipranavir drug:Telithromycin drug:Ketoconazole drug:Fenofibrate drug:Rifampicin drug:Atazanavir drug:Anisindione drug:Nefazodone drug:Itraconazole drug:Clarithromycin drug:Saquinavir drug:Gemfibrozil drug:Darunavir drug:Fosamprenavir drug:Josamycin drug:Quinupristin drug:Bezafibrate drug:Colchicine drug:Danazol drug:Acenocoumarol drug:Telaprevir drug:Etravirine drug:Ticagrelor drug:Lomitapide
owl:sameAs	drug:APRD00370 drug:Cyclosporine drug:Cholecalciferol drug:Fluconazole drug:Erythromycin drug:Azithromycin drug:Nelfinavir drug:Indinavir drug:Lovastatin drug:Nevirapine drug:Dicoumarol drug:Diltiazem drug:Ritonavir drug:Bosentan drug:Carbamazepine drug:Voriconazole drug:Rifabutin drug:Imatinib drug:Efavirenz drug:Niacin drug:Verapamil drug:Warfarin drug:Amprenavir drug:Delavirdine drug:Tipranavir drug:Telithromycin drug:Ketoconazole drug:Fenofibrate drug:Rifampicin drug:Atazanavir drug:Anisindione drug:Nefazodone drug:Itraconazole drug:Clarithromycin drug:Saquinavir drug:Gemfibrozil drug:Darunavir drug:Fosamprenavir drug:Josamycin drug:Quinupristin drug:Bezafibrate drug:Colchicine drug:Danazol drug:Acenocoumarol drug:Iron drug:Geranyl Diphosphate drug:Cholesterol drug:Telaprevir drug:Etravirine drug:Ticagrelor drug:Lomitapide

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines3/drugbank_small.nt

The resource appears as object in 95 triples

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